Dietary Factors Impact Developmental Trajectories in Young Autistic Children.

PURPOSE: The purpose of this research was to investigate the impact of dietary factors on developmental trajectories in young autistic children. METHODS: A gluten-free and casein-free diets, as well as six types of food (meat and eggs, vegetables, uncooked vegetables, sweets, bread, and "white soft bread that never molds") were investigated observationally for up to three years in 5,553 children 2 to 5 years of age via parent-report measures completed within a mobile application. Children had a parent-reported diagnosis of Autism Spectrum Disorder (ASD); 78% were males; the majority of participants resided in the USA. Outcome was monitored on five orthogonal subscales: Language Comprehension, Expressive Language, Sociability, Sensory Awareness, and Health, assessed by the Autism Treatment Evaluation Checklist (ATEC) (Rimland & Edelson, 1999) and Mental Synthesis Evaluation Checklist (MSEC) (Arnold & Vyshedskiy, 2022; Braverman et al., 2018). RESULTS: Consumption of fast-acting carbohydrates - sweets, bread, and "white soft bread that never molds" - was associated with a significant and a consistent Health subscale score decline. On the contrary, a gluten-free diet, as well as consumption of meat, eggs, and vegetables were associated with a significant and consistent improvement in the Language Comprehension score. Consumption of meat and eggs was also associated with a significant and consistent improvement in the Sensory Awareness score. CONCLUSION: The results of this study demonstrate a strong correlation between a diet and developmental trajectories and suggest possible dietary interventions for young autistic children.

'Space to talk': a Portuguese focus group study of parents' experiences, needs and preferences in parenting support during prenatal and well-child care.

OBJECTIVE: To explore the experiences, needs and preferences of a group of parents regarding the parenting support received during prenatal and well-child care in the Portuguese National Health Service. DESIGN AND SETTING: We undertook descriptive-interpretive qualitative research running multiple focus groups in Porto, Northern Portugal. PARTICIPANTS, DATA COLLECTION AND ANALYSIS: Purposive sampling was used between April and November 2018. Focus groups were conducted with 11 parents of a 0-3 years old with well-child visits done in primary care units. Thematic analysis was performed in a broadly inductive coding strategy and findings are reported in accordance with Consolidated Criteria for Reporting Qualitative Research guidelines. RESULTS: Three main themes were identified to describe parents' experience when participating in their children's healthcare: (1) logistics/delivery matter, including accessibility, organisation and provision of healthcare activities, unit setting and available equipment; (2) prenatal and well-child care: a relational place to communicate, with parents valuing a tripartite space for the baby, the family and the parent himself, where an available and caring health provider plays a major role and (3) parenting is challenging and looks for support, based on key points for providers to watch for and ask about, carefully explained and consensual among health providers. CONCLUSION: This study provides insight into parents' needs and healthcare practices that affect the parenting experience. To meet parents' preferences, sensitive health providers should guarantee a relational place to communicate and person-centredness, accounting for the whole family system to support healthy parenting collaboratively. Future studies are warranted to further strengthen the knowledge in the field of a population-based approach for parenting support.

Pediatric Occupational Therapists and Occupational Stress: A Scoping Review.

The purpose of this scoping review was to provide further insight into the stress and the stressors experienced by pediatric occupational therapists in the work environment. Using the Arksey and O'Malley framework, the search was conducted in eight databases, nine electronic journals, and eight gray literature sources to identify articles related to stress and stressors of pediatric occupational therapists. Review selection and characterization were performed by two independent reviewers. Twelve articles published from 2011 to 2020 were identified and varied in terms of purpose, population, and results although the articles all shared similar methodologies and outcome measures. Only 25% of the articles (3/12) addressed pediatric occupational therapy stress and stressors directly while the remaining addressed occupational stress, but with varying levels of attention to pediatric occupational therapists. Stress and stressors experienced by pediatric occupational therapists have been studied to a limited extent. Occupational stress is associated with increased burnout, decreased health, and decreased job satisfaction and performance. Several knowledge gaps have been identified, as well as priorities for future research into pediatric occupational therapists and occupational stress.

Regul-A: A Technological Application for Sensory Regulation of Children with Autism Spectrum Disorder in the Home Context.

(1) Background: Sensory processing disorder is now recognised as a core feature of autism spectrum disorder that influences children's adaptive behaviours, which, in turn, may interfere with their participation in life situations. This study describes the process of developing a technological platform, in the form of an app, to help families regulate children with ASD, aged 3-6 years old, by applying sensory strategies to improve the child's participation in daily routines in the home context. (2) Methods: A focus group formed by four specialised occupational therapists who intervene with children with ASD was selected in order to understand and discuss content that should be included in the app. At a later stage, a group of three was involved to ensure quality and veracity in technological platform elaboration. (3) Results: The purpose of the app, named Regul-A, is to help parents regulate children with ASD regarding their participation in home routines. The sensory strategies provided by the focus group in the three major occupations of the child were the first results obtained, followed by the development of the app structure. (4) Conclusions: The next phase of the study will be the use of the platform by families of children with ASD and occupational therapists. It is believed that, in the future, Regul-A will be used as a tool to gather, analyse and manage data on the occupational performance of children with ASD in the home context, particularly for activities of daily living, sleep, rest and play, facilitating the implementation of strategies and the sharing of information between parents and occupational therapists.

Sexually transmitted infections among women living with HIV in a Brazilian city.

BACKGROUND: Clinical improvements following highly active antiretroviral therapy (HAART) may increase high-risk behaviors resulting in sexually transmitted infections (STI). Optimism related to the success of HAART in slowing disease progression, reducing viral load, and improving health status might be important factors for increasing sexual risk behaviors such as less use of condoms. OBJECTIVE: To determine the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, hepatitis B and C, high-risk HPV, and cervical cytological abnormalities among women living with HIV (WLHIV) who attended a Reference Center for STI/AIDS in Brazil. METHODS: A cross-sectional study was conducted among 151 WLHIV attending an STI Clinic in Vitória city, Brazil. A structured questionnaire, including demographic, behavioral, and clinical information, was used for data collection. Serological tests for HIV, syphilis, hepatitis C and B, CD4 counts, and viral load determination were performed. Cervical samples were collected for cytology and real-time PCR for HPV,Chlamydia, and Neisseria gonorrhoeae. RESULTS: In this study, 59% of women had at least one diagnosed STI at the time of the first clinic visit; 31% had clinical forms of anogenital HPV, 10% syphilis, 8%Neisseria gonorrhoeae, 5.0% trichomoniasis, 3% Chlamydia trachomatis, 1% hepatitis B, and 1% hepatitis C; 6.7% of the women presented with cervical cytological abnormalities. Furthermore, 46.3% of women had HR-HPV, and 17.6% had HPV 16/18. Only 5% of the women had a CD4 count <200 cells/mm3, 61.6% had undetectable HIV viral load, and 81.3% were currently on HAART. CONCLUSION: A high prevalence of STI and HR-HPV infections were observed among HIV-infected women in this investigation. Prevention programs need to focus on counseling WLHIV and their regular partners with focused interventions such as couples counseling and education programs.

Instrument content validation for teaching the nursing process in a post-anesthetic recovery room / Validação de conteúdo de instrumento para o ensino do processo de enfermagem em sala de recuperação pós-anestésica

Objective: To build and validate the content of an instrument to support the teaching and learning of the nursing process in the Post-Anesthetic Recovery Room, intended for nursing students. Method: This is a methodological study with a quantitative approach. In the content validation, seven judges, nurse doctors and postdoctors participated in teaching and research in the area of ​​perioperative nursing. In the semantic analysis, 30 nursing students participated. The construction of the instrument was based on a literature review, Horta's theoretical framework and a nursing classification system. In data analysis, the Content Validity Index and the Agreement Index were calculated. Results: In the content validation, the instrument obtained Content Validity Index high in the psychometric criteria: relevance (CVI = 0.99), clarity (CVI = 1) and objectivity (CVI = 1). In the semantic analysis, the concordance index of the items was also high (CI> 0.80). Conclusion: The instrument was considered valid and understandable, with the potential to be a pedagogical tool that facilitates the process of caring for patients in the Post-Anesthetic Recovery Room.

Objetivo: Construir e validar o conteúdo de um instrumento para subsidiar o ensino e aprendizagem do processo de enfermagem em Sala de Recuperação Pós-Anestésica, destinado aos acadêmicos de enfermagem. Método: Trata-se de um estudo metodológico com abordagem quantitativa. Na validação de conteúdo participaram sete juízes, enfermeiros doutores e pós-doutores atuantes no ensino e pesquisa na área da enfermagem perioperatória. Na análise semântica, participaram 30 acadêmicos de enfermagem. A construção do instrumento foi pautada em revisão de literatura, referencial teórico de Horta e sistema de classificação de enfermagem. Na análise dos dados, o Índice de Validade de Conteúdo e o Índice de Concordância foram calculados. Resultados: Na validação de conteúdo, o instrumento obteve Índice de Validade de Conteúdo elevados nos critérios psicométricos relevância (IVC =0,99), clareza (IVC=1) e objetividade (IVC=1). Na análise semântica, o Índice de Concordância dos itens também foi elevado (IC>0,80). Conclusão: O instrumento foi considerado válido e compreensível, com potencial para ser uma ferramenta pedagógica facilitadora do processo de cuidar dos pacientes em Sala de Recuperação Pós-Anestésica.

Sexually transmitted infections among women living with HIV in a Brazilian city

ABSTRACT Background: Clinical improvements following highly active antiretroviral therapy (HAART) may increase high-risk behaviors resulting in sexually transmitted infections (STI). Optimism related to the success of HAART in slowing disease progression, reducing viral load, and improving health status might be important factors for increasing sexual risk behaviors such as less use of condoms. Objective: To determine the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, hepatitis B and C, high-risk HPV, and cervical cytological abnormalities among women living with HIV (WLHIV) who attended a Reference Center for STI/AIDS in Brazil. Methods: A cross-sectional study was conducted among 151 WLHIV attending an STI Clinic in Vitória city, Brazil. A structured questionnaire, including demographic, behavioral, and clinical information, was used for data collection. Serological tests for HIV, syphilis, hepatitis C and B, CD4 counts, and viral load determination were performed. Cervical samples were collected for cytology and real-time PCR for HPV, Chlamydia, and Neisseria gonorrhoeae. Results: In this study, 59% of women had at least one diagnosed STI at the time of the first clinic visit; 31% had clinical forms of anogenital HPV, 10% syphilis, 8%Neisseria gonorrhoeae, 5.0% trichomoniasis, 3% Chlamydia trachomatis, 1% hepatitis B, and 1% hepatitis C; 6.7% of the women presented with cervical cytological abnormalities. Furthermore, 46.3% of women had HR-HPV, and 17.6% had HPV 16/18. Only 5% of the women had a CD4 count <200 cells/mm3, 61.6% had undetectable HIV viral load, and 81.3% were currently on HAART. Conclusion: A high prevalence of STI and HR-HPV infections were observed among HIV-infected women in this investigation. Prevention programs need to focus on counseling WLHIV and their regular partners with focused interventions such as couples counseling and education programs.

Versão Portuguesa da Medida do Processamento Sensorial Préescola: Análise da Consistência Interna e Homogeneidade dos Itens do Formulário Escola / A Portuguese Version of the Sensory Processing Measure for Preschool: Analysis of the Internal Consistency and Homogeneity of the Items of School Form

RESUMO: Nos últimos anos, tem havido na literatura uma larga estimativa de prevalência de desordens do processamento sensorial. A avaliação dessas dificuldades deve fazer parte da competência dos profissionais que desenvolvem o seu trabalho com crianças que as apresentam por meio de instrumentos validados. Este estudo examina a consistência interna e homogeneidade dos itens da versão portuguesa do Sensory Processing Measure-Preschool (SPM-P). Foi aplicado o SPM-P a cem crianças entre os 2 e os 5 anos de idade que frequentavam a creche e o jardim de infância com o objetivo de determinar a sua fiabilidade e a validade. A análise da correlação de Pearson (homogeneidade dos itens) e do alfa de Cronbach (consistência interna) determinou a exclusão de quatro itens. Os valores de alfa de Cronbach para as várias dimensões ("Participação Social", "Visão", "Audição", "Toque", "Consciência Corporal", "Equilíbrio", "Planeamento Motor e Ideias") oscilou entre ‹=0.742 ("Visão" e "Toque") e ‹=0.908 ("Consciência Corporal"). Os resultados deste estudo mostram que o SPM-P é um instrumento de rastreio válido e fiável para despistar as dificuldades de processamento sensorial das crianças Portuguesas com idades compreendidas entre os 2 e os 5 anos integradas em contexto escolar.

ABSTRACT: Over the past several years, a wide range of estimates of the prevalence of sensory processing disorders has emerged in the literature. The assessment of these difficulties should be part of the competence of professionals working with children with these kinds of needs through validated instruments. This study examined the internal consistency and items homogeneity of a Portuguese language version of the Sensory Processing Measure-Preschool (SPM-P). One hundred typically developing children aged between 2 and 5 years were recruited at Nursery Schools and assessed using the SPM-P to determine its reliability and validity. Pearson correlation (item homogeneity) and Cronbach's alpha (internal consistency) determined the exclusion of 4 items. Cronbach's alpha values for the different dimensions ("Social Participation", "Vision", "Hearing", "Touch", "Body Awareness", "Balance and Motion", "Planning and Ideas") ranged from 0.742 ("Vision" and "Touch") and 0.908 ("Body Awareness"). The findings of this study showed that the SPM-P is a valid and reliable tool in screening for sensory processing difficulties in Portuguese preschool children aged between 2 and 5 years in a nursery school setting.

Genome maintenance functions of a putative Trypanosoma brucei translesion DNA polymerase include telomere association and a role in antigenic variation.

Maintenance of genome integrity is critical to guarantee transfer of an intact genome from parent to offspring during cell division. DNA polymerases (Pols) provide roles in both replication of the genome and the repair of a wide range of lesions. Amongst replicative DNA Pols, translesion DNA Pols play a particular role: replication to bypass DNA damage. All cells express a range of translesion Pols, but little work has examined their function in parasites, including whether the enzymes might contribute to host-parasite interactions. Here, we describe a dual function of one putative translesion Pol in African trypanosomes, which we now name TbPolIE. Previously, we demonstrated that TbPolIE is associated with telomeric sequences and here we show that RNAi-mediated depletion of TbPolIE transcripts results in slowed growth, altered DNA content, changes in cell morphology, and increased sensitivity to DNA damaging agents. We also show that TbPolIE displays pronounced localization at the nuclear periphery, and that its depletion leads to chromosome segregation defects and increased levels of endogenous DNA damage. Finally, we demonstrate that TbPolIE depletion leads to deregulation of telomeric variant surface glycoprotein genes, linking the function of this putative translesion DNA polymerase to host immune evasion by antigenic variation.

Severe coronavirus infection in pregnancy: challenging cases report.

There are few data on the impact of COVID-19 in pregnancy, however, analyzing these data is important to guide the clinical practice, covering the early prevention, detection, patients' isolation, epidemiological investigation, diagnosis and early treatment. This is a report of three cases of COVID-19 confirmed by real-time reverse transcription - polymerase chain reaction (RT-PCR) of nasopharyngeal secretions collected in swabs from pregnant women in the city of Vitoria, Espirito Santo State, Brazil. In the three cases, all the patients presented with fever, one had shortness of breath, one had diarrhea, two of them reported abdominal pain and two of them had cough. The three patients progressed with a severe clinical evolution of COVID-19. The permanence in the intensive care unit (ICU) was more than 10 days. Two of them recovered and one remained in the ICU with irreversible refractory shock, multiple organ failure and died. The mode of delivery was individualized and based on the obstetric indication and severity of the maternal infection, and the cesarean section was indicated in the two severe maternal COVID-19 cases that evolved favorably. These newborns were premature and tested negative for COVID-19 by RT-PCR.

Placental growth disorders and perinatal adverse outcomes in Brazilian HIV-infected pregnant women.

Fetal and placental growth disorders are common in maternal human immunodeficiency virus (HIV) infection and can be attributed to both the infection and comorbidities not associated with HIV. We describe placental growth disorders and adverse reproductive outcomes in HIV-infected pregnant women whose delivery occurred between 2001-2014 in Vitoria, Brazil. Cases with gestational age (GA) ≥ than 22 weeks validated by ultrasonography, with placental and fetal weight dimensions at birth, were studied. Outcomes were summarized as proportions of small (SGA), appropriate (AGA), and large (LGA) for GA when the z-score values were below -1.28, between -1.28 and +1.28, or above +1.28, respectively. Of 187 fetal attachment requisitions, 122(65.2%) women and their newborns participated in the study. The median maternal age was 28 years and 81(66.4%) underwent ≥ 6 prenatal visits. A total of 81(66.4%) were diagnosed before current pregnancy; 68(55.7%) exhibited criteria for acquired immunodeficiency syndrome (AIDS); 64(52.4%) had detectable viral load; 25(20.5%) cases presented SGA placental weight and 6(4.9%) SGA placental thickness. SGA placental area was observed in 41(33.6%) cases, and among the SGA placental weight cases 12(48%) were also SGA fetal weight. Preterm birth (PTB) occurred in 15.6%(19/122) of cases; perinatal death in 4.1%(5/122) and HIV vertical transmission in 6 of 122 (4.9%). Women, ≥36 years old, were 5.7 times more likely to have PTB than those under 36. Also, patients with AIDS-defining criteria were 3.7 times more likely to have PTB. Prenatal care was inversely associated with PTB. Statistically significant associations were observed between AGA placental area and Protease Inhibitor usage and between SGA placental weight and SGA area. We found a prevalence of placental growth disorders in HIV-infected pregnant women and values higher than international reference values. The restriction of placental growth was a common disorder, possibly attributed to virus effects or a combination of antiretroviral regimens.

Hypertrophic genital herpes in an HIV-infected female patient: Imiquimod as an alternative treatment.

Herpes Simplex Virus (HSV) is the leading cause of genital ulcers worldwide. In Human Immunodeficiency Virus (HIV) co-infected individuals, rare hypertrophic pseudo-tumoral forms have been described as simulating squamous cell carcinoma or other viral infections such as those caused by Varicella zoster, Molluscum contagiosum and HPV induced lesions. Here, we report a case of hypertrophic genital herpes in an HIV-infected patient effectively treated with surgery and topical 5% imiquimod after the recurrence of lesions. A 45-year-old woman, HIV-positive for 17 years and on regular antiretroviral therapy, presented with a painful 2cm vulvar sessile lesion, a 1cm ulcerated lesion on the clitoral hood, and a slightly elevated lesion in the middle third of the tongue. Excisional biopsy and surgical removal of lesion were performed for histopathological exam. Histopathology of genital lesions showed evidence of chronic lymphoplasmacytic inflammation, intense ulcerated plasmacytosis, and squamous cells displaying HSV cytopathogenic effect. After three months, the patient presented with a new ulcerated perineal lesion. Histopathology showed evidence of chronic ulcerative-vegetative herpetic dermatitis. Consequently, topical 5% imiquimod was administered with successful results. Relapsing character and atypical genital disease evolution with an exophytic pseudotumoral injury have been noted in patients co-infected with HIV and HSV, necessitating anatomopathological recognition for diagnostic confirmation and exclusion of malignancy. Local immunotherapy should be considered as treatment approach.

Syphilis among HIV serodiscordant partners associated with Human Papillomavirus Infection in a bisexual man / Sífilis entre parceiros sorodiscordantes para HIV associada à infecção por papilomavírus humano em um homem bissexual

Introduction: Syphilis and HIV infections are sexually transmitted infections whose diagnosis and treatment contribute toward preventing congenital transmission. Objective: To report a case of three sexually transmitted infections detected in a male partner during Couple Consultation and syphilis in the female partner during prenatal care. Case report: A 34-year-old black female G2P1 pregnant woman was referred to an outpatient clinic of sexually transmitted infections in Vitória, Brazil, reporting a 30-day evolution of painless papular lesions in the external genitalia, suggestive of condylomata lata. Nontreponemal tests were positive for syphilis and negative for HIV. The husband reported unprotected receptive anal intercourse and possessed anal condylomatous lesions and perianal condylomata lata. He was positive for both HIV and syphilis. Histopathological findings showed low-grade HPV lesions and the PCR test found 16, 39, and 53 HPV subtypes. Treatment with benzathine penicillin G was successful for both partners. Conclusion: This study emphasizes the need for Couple Consultation during pregnancy to identify and treat possible sexually transmitted infections.

Introdução: As infecções por sífilis e HIV são infecções sexualmente transmissíveis cujo diagnóstico e tratamento contribuem para a prevenção da transmissão congênita. Objetivo: Relatar um caso de três infecções sexualmente transmissíveis detectadas em um parceiro masculino durante a consulta do casal e sífilis na parceira durante o pré-natal. Relato de caso: Uma gestante, negra, G2P1, 34 anos, foi encaminhada a um ambulatório de infecções sexualmente transmissíveis em Vitória, Brasil, relatando uma evolução de 30 dias de lesões papulares indolores na genitália externa, sugestivas de condiloma lata. Os testes não treponêmicos foram positivos para sífilis e negativos para HIV. O marido relatou relação sexual anal receptiva desprotegida e possuía lesões condilomatosas anais e condiloma lata perianal. Ele testou positivo tanto para HIV quanto para sífilis. Os achados histopatológicos mostraram lesão de HPV de baixo grau e o teste de PCR encontrou subtipos de HPV 16, 39 e 53. O tratamento com penicilina benzatina G foi bem­sucedido em ambos os parceiros. Conclusão: Este estudo enfatiza a necessidade de consultas de casal durante a gravidez para identificar e tratar possíveis infecções sexualmente transmissíveis.

Rollet's mixed chancre in Brazilian pregnant women: An unusual case report.

Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum and has shown a significant increase in recent decades. It may be associated with other STIs such as soft chancre or chancroid, which is an uncommon infection in Brazil. The presence of ulcerated genital lesions is associated with a higher risk of HIV transmission. An accurate clinical and laboratory diagnosis of genital ulcer disease is essential for the appropriate treatment of pregnant women, in order to avoid congenital syphilis, a severe complication of mother-to-child vertical transmission. We report the case of a woman in the third trimester of pregnancy with Rollet's mixed chancre and describe the clinical and laboratory diagnosis, as well as the treatment of these diseases in pregnancy. We emphasize the importance of training health professionals on early diagnosis and treatment in order to avoid mother-to-child transmission.

Disfunções dos músculos do assoalho pélvico em mulheres que realizam o exame preventivo de câncer de colo de útero / Pelvic floor dysfunctions in women undergoing cervical cancer screening

Introdução: As disfunções dos músculos do assoalho pélvico (DMAP) ocorrem devido a alterações das estruturas da região pélvica. A identificação de sintomas no exame preventivo de câncer de colo de útero é importante para aprimorar políticas públicas de atenção à saúde da mulher. Objetivo: Analisar a prevalência de DMAP em mulheres que realizam exame preventivo de câncer de colo de útero. Métodos: Tratou-se de um estudo transversal cuja população foi composta por 64 mulheres adultas. Os instrumentos de pesquisa utilizados foram ficha de identificação de DMAP e ficha de identificação de fatores associados as DMAP. Resultados: Constipação (40,6%), incontinência urinária (IU) (39,1%) e dispareunia (23,4%) foram as mais prevalentes, com 39,1% das mulheres apresentando sintomas de uma única disfunção, 21,9% duas disfunções e 9,4% associação de três disfunções, 44% das mulheres com IU também apresentam constipação e 28% com IU apresentavam dispareunia. Nenhum fator demonstrou associação à constipação, IU demonstrou uma tendência à associação ao consumo de cafeína e dispareunia ao uso de medicamentos Inibidores da Enzima Conversora de Angiotensina. Conclusão: Observou-se maior prevalência de constipação, IU e dispareunia destacando-se a sobreposição de sintomas, enfatizando a importância da detecção precoce das DMAP ainda na atenção primária. (AU)

Introduction: Pelvic floor dysfunctions (PFD) occur due to changes in the structures of the pelvic region. The identification of symptoms in the cervical cancer screening is important to improve public health care for women. Objective: To analyze the prevalence of PFD in women who undergo cervical cancer screening test. Methods: This was a cross-sectional study whose population was composed of 64 adult women. The research instruments used were a PFD identification form and a PFD identification card. Results: Constipation (40.6%), Urinary Incontinence (UI) (39.1%) and dyspareunia (23.4%) were the most prevalent, with 39.1% of the women presenting with a single dysfunction, 21.9% two dysfunctions and a 9.4% association of three dysfunctions, 44% of women with UI also presented constipation and 28% with UI had dyspareunia. No factor was associated with constipation, UI showed a trend to association with caffeine consumption and dyspareunia with the use of ACE inhibitors. Conclusion: A higher prevalence of constipation, UI and dyspareunia was observed, with overlapping of symptoms, emphasizing the importance of the early detection of PFD still in the primary care, for the prevention and treatment of these symptoms. (AU)

Giant condylomata acuminata of Buschke-Lowenstein: Surgical method as effective treatment and Imiquimod as adjuvant therapy in an immunocompetent patient / Condiloma acuminado gigante de Buschke-Lowenstein: Método cirúrgico como tratamento eficaz e Imiquimode como terapia adjuvante em uma paciente imunocompetente

Introduction: Giant condylomata acuminata, also known as Buschke-Lowenstein tumor is a rare form of tumor of the anogenital condylomata acuminata, which is a sexually transmitted infection (STI) caused by the human papillomavirus (HPV). Objective: To report a case of giant condylomata acuminata in an immunocompetent patient. Case report: The patient was referred to the Outpatient Clinic for Sexually Transmitted Infections and AIDS at a public hospital in the city of Vitória, Espírito Santo State, Brazil, reporting the onset of progressive growth verrucous lesions on the external genitalia for four months. The patient underwent surgical ablation, and giant condylomata diagnostic confirmation was obtained through histopathology. She was treated with 5% imiquimod cream in routine applications for eight consecutive weeks to avoid recurrence and was also vaccinated for HPV after the procedure. Conclusion: Surgery excision is the treatment of choice in extensive genital condylomata lesions to exclude malignancy. Imiquimod use as adjuvant therapy for reducing recurrence seems to be adequate.

Introdução: O condiloma acuminado gigante, também conhecido tumor de Buschke-Lowenstein, é uma apresentação rara do condiloma acuminado anogenital, que é uma infecção sexualmente transmissível (IST) causada pelo papilomavírus humano (HPV). Objetivo: Relatar um caso de condiloma acuminado gigante em uma paciente imunocompetente. Relato de caso: A paciente foi encaminhada para o ambulatório de infecções sexualmente transmissíveis e AIDS de um hospital público na cidade de Vitória, Espírito Santo, Brasil, relatando o aparecimento de lesões verrucosas de crescimento progressivo na genitália externa por quatro meses. A paciente foi submetida à exérese cirúrgica e a confirmação diagnóstica de condiloma gigante foi obtida através da histopatologia. Ela foi medicada com imiquimode creme a 5% em aplicações rotineiras por oito semanas consecutivas para evitar recorrências e foi também vacinada contra o HPV após o procedimento. Conclusão: Exérese cirúrgica é o tratamento de escolha em lesões condilomatosas extensas para excluir malignidade. O uso de Imiquimode como terapia adjuvante para redução de recidivas mostrou-se adequado.