ABSTRACT
Urine production, glomerular filtration rate (GFR) and Na+ transport of the kidney were studied in rats after complete substitution of the blood with a fluorocarbon emulsion. The urine production is found to be increased, the GFR lowered. The Na+ load as a function of the GFR is reduced while the relative Na+ reabsorption with values in the range of 98-99% of the load is normal.
Subject(s)
Kidney/physiology , Plasma Substitutes , Animals , Biological Transport , Emulsions , Exchange Transfusion, Whole Blood , Fluorocarbon Polymers , Glomerular Filtration Rate , Rats , Sodium/metabolism , UrinationABSTRACT
Dog kidneys have been perfused with homologous plasma at plus 6 degrees-C for 24 and 48 h and the water, K+ and Na+ variations in the cortex and medulla have been studied. After 24 h perfusion Na+-gain and K+-loss in the cortex are found while water content shows no changes. After 48 h perfusion additional increase of Na+ and gain of water are observed while the K+ content remains unchanged as compared with the cortex after 24 h perfusion time. In the medulla after 24 h perfusion K+ loss and water gain are registered while the Na+ content remains unchanged. In the following 24 h no additional changes of the K+, Na+ or water contents are observed.