Securing Public Trust: Dentistry, SARS-CoV-2, and "Testing for Tomorrow".

The SARS-CoV-2 pandemic created societal upheaval well beyond what anyone, but the oldest of Americans, has seen in their lifetime. As the pandemic begins to subside, it is leaving behind a legacy of permanently changed practices, including enhanced environmental controls in clinical settings, reconsideration of modes of personal protective equipment outsourcing, changes and/or reinterpretation of dental practice acts, and entirely new approaches to testing and vaccine design, among many others. This article focuses on one change that the authors hope will prevail: greater trust in the dental profession as a valuable public resource during healthcare crises. The article cites the initial low perception of dentistry as an important component of a health surge response by public health authorities, then describes how a group of eight institutions came together to form the "Testing for Tomorrow Collaborative" to help each other and the dental profession identify modes of testing and practice conduct that make dentistry safer to practice. The importance of the public's trust in the profession is underscored, and pathways to improving that trust are proffered.

Digital dentistry: The new state of the art - Is it disruptive or destructive?

OBJECTIVE: Summarizing the new state of the art of digital dentistry, opens exploration of the type and extent of innovations and technological advances that have impacted - and improved - dentistry. The objective is to describe advances and innovations, the breadth of their impact, disruptions and advantages they produce, and opportunities created for material scientists. METHODS: On-line data bases, web searches, and discussions with industry experts, clinicians, and dental researchers informed the content. Emphasis for inclusion was on most recent publications along with innovations presented at trade shows, in press releases, and discovered through discussions leading to web searches for new products. RESULTS: Digital dentistry has caused disruption on many fronts, bringing new techniques, systems, and interactions that have improved dentistry. Innovation has spurred opportunities for material scientists' future research. SIGNIFICANCE: With disruptions intrinsic in digital dentistry's new state of the art, patient experience has improved. More restoration options are available delivering longer lifetimes, and better esthetics. Fresh approaches are bringing greater efficiency and accuracy, capitalizing on the interest, capabilities, and skills of those involved. New ways for effective and efficient inter-professional and clinician-patient interactions have evolved. Data can be more efficiently mined for forensic and epidemiological uses. Students have fresh ways of learning. New, often unexpected, partnerships have formed bringing further disruption - and novel advantages. Yes, digital dentistry has been disruptive, but the abundance of positive outcomes argues strongly that it has not been destructive.

Conventional and modified veneered zirconia vs. metalloceramic: fatigue and finite element analysis.

PURPOSE: The purpose of this study was to test the hypothesis that all-ceramic crown core-veneer system reliability is improved by modifying the core design and as a result is comparable in reliability to metal-ceramic retainers (MCR). Finite element analysis (FEA) was performed to verify maximum principal stress distribution in the systems. MATERIALS AND METHODS: A first lower molar full crown preparation was modeled by reducing the height of proximal walls by 1.5 mm and occlusal surface by 2.0 mm. The CAD-based preparation was replicated and positioned in a dental articulator for specimen fabrication. Conventional (0.5 mm uniform thickness) and modified (2.5 mm height, 1 mm thickness at the lingual extending to proximals) zirconia (Y-TZP) core designs were produced with 1.5 mm veneer porcelain. MCR controls were fabricated following conventional design. All crowns were resin cemented to 30-day aged composite dies, aged 14 days in water and either single-loaded to failure or step-stress fatigue tested. The loads were positioned either on the mesiobuccal or mesiolingual cusp (n = 21 for each ceramic system and cusp). Probability Weibull and use level probability curves were calculated. Crack evolution was followed, and postmortem specimens were analyzed and compared to clinical failures. RESULTS: Compared to conventional and MCRs, increased levels of stress were observed in the core region for the modified Y-TZP core design. The reliability was higher in the Y-TZP-lingual-modified group at 100,000 cycles and 200 N, but not significantly different from the MCR-mesiolingual group. The MCR-distobuccal group showed the highest reliability. Fracture modes for Y-TZP groups were veneer chipping not exposing the core for the conventional design groups, and exposing the veneer-core interface for the modified group. MCR fractures were mostly chipping combined with metal coping exposure. CONCLUSIONS: FEA showed higher levels of stress for both Y-TZP core designs and veneer layers compared to MCR. Core design modification resulted in fatigue reliability response of Y-TZP comparable to MCR at 100,000 cycles and 200 N. Fracture modes observed matched with clinical scenarios.

Bond strength to high-crystalline content zirconia after different surface treatments.

The aim of this study was to evaluate the effect of primers, luting systems and aging on bond strength to zirconium oxide substrates. Eighteen zirconia discs (19.5 x 4 mm) were polished and treated (n = 3) either with a MDP primer (Md) or with a MDP and VBATDT primer (MV). In the control group (n = 3) no surface chemical treatment was performed. Zirconia specimens were cemented to prepolymerized composite discs utilizing resin cements - RelyX Unicem or Panavia 21 (RU and Pa, respectively). After 24 h, samples were sectioned for microtensile testing and returned to water at 37 degrees C for two different periods before being tested: 72 h or 60 days + thermocycling (5-55 degrees C/5000 cycles). Bond strength testing was performed at 1 mm/min. Values in MPa were analyzed through ANOVA and Tukey's Studentized Range (HSD) (p > 0.05). The application of MV primer resulted in the highest bond strength (22.77 MPa), statistically superior to Md primer (12.78 MPa), and control groups presented the lowest values (9.17 MPa). When luting systems were compared, RU promoted the highest bond strength (16.07 MPa) in comparison with Pa (13.75 MPa). The average bond strength decrease after aging (9.35 MPa) when compared with initial values (20.46 MPa). The results presented by this in vitro study suggest that a chemical surface treatment based on the MDP and VBATDT combination may improve bond strength between zirconia and luting system, without any previous mechanical treatment, depending on the luting system used. This chemical treatment may result in a reliable alternative to achieve adequate and durable bond strength.

Design features of a three-dimensional molar crown and related maximum principal stress. A finite element model study.

OBJECTIVE: To evaluate the effects of clinically relevant variables on the maximum principal stress (MPS) in the veneer layer of an anatomically correct veneer-core-cement-tooth model. METHODS: The average dimensions of a mandibular first molar crown were imported into CAD software; a tooth preparation was modeled by reducing the proximal walls by 1.5 mm and the occlusal surface by 2.0 mm. 'Crown systems' were composed by varying characteristics of a cement layer, structural core, and veneer solid, all designed to fit the tooth preparation. The main and interacting effects of proximal wall height reduction, core material, core thickness, cement modulus, cement thickness, and load position on the maximum stress distribution were derived from a series of finite element models and analyzed in a factorial analysis of variance. RESULTS: The average MPS in the veneer layer over the 64 models was 488 MPa (range = 248-840 MPa). MPS increased significantly with the addition of horizontal load components and with increasing cement thickness. In addition, MPS levels varied as a function of interactions between: proximal wall height reduction and load position; load position and cement thickness; core thickness and cement thickness; cement thickness and proximal wall height reduction; and core thickness, cement thickness and proximal wall height reduction. CONCLUSION: Rational design of veneered structural ceramics must consider the complex geometry of the crown-tooth system and integrate the influence of both the main effects and interactions among design parameters.

A novel approach to multihazard modeling and simulation.

OBJECTIVE: To develop and apply a novel modeling approach to support medical and public health disaster planning and response using a sarin release scenario in a metropolitan environment. METHODS: An agent-based disaster simulation model was developed incorporating the principles of dose response, surge response, and psychosocial characteristics superimposed on topographically accurate geographic information system architecture. The modeling scenarios involved passive and active releases of sarin in multiple transportation hubs in a metropolitan city. Parameters evaluated included emergency medical services, hospital surge capacity (including implementation of disaster plan), and behavioral and psychosocial characteristics of the victims. RESULTS: In passive sarin release scenarios of 5 to 15 L, mortality increased nonlinearly from 0.13% to 8.69%, reaching 55.4% with active dispersion, reflecting higher initial doses. Cumulative mortality rates from releases in 1 to 3 major transportation hubs similarly increased nonlinearly as a function of dose and systemic stress. The increase in mortality rate was most pronounced in the 80% to 100% emergency department occupancy range, analogous to the previously observed queuing phenomenon. Effective implementation of hospital disaster plans decreased mortality and injury severity. Decreasing ambulance response time and increasing available responding units reduced mortality among potentially salvageable patients. Adverse psychosocial characteristics (excess worry and low compliance) increased demands on health care resources. Transfer to alternative urban sites was possible. CONCLUSIONS: An agent-based modeling approach provides a mechanism to assess complex individual and systemwide effects in rare events.

Competition of fracture mechanisms in monolithic dental ceramics: flat model systems.

Monolithic (single layer) glass-ceramic restorations often fail from chipping and fracture. Using blunt indentation of a model flat porcelain-like brittle layer bonded onto a dentin-like polymer support system, a variety of fatigue fracture modes has been identified and analyzed: outer cone, inner cone, and median cracks developing in the near-contact region at the occlusal surface; radial cracks developing at the internal cementation surface along the loading axis. Our findings indicate that monolithic glass-ceramic layers are vulnerable to both occlusal surface damage and cementation internal surface fracture. Clinical issues in the longevity of ceramic restorations are discussed in relation to biting force, physical properties of ceramic crowns and luting cement, and thicknesses of ceramic and cement layers.

Effects of geometry on fracture initiation and propagation in all-ceramic crowns.

The complex and patient-unique geometry of posterior all-ceramic dental crowns represents a particularly interesting set of challenges to understanding stress concentration and fracture evolution in response to loading. A series of numerical and physical experiments, with both single cycle and fatigue loading, show that geometry profoundly influences the stress concentration and fracture initiation and propagation. In stylized crowns with uniform axial wall height, stresses concentrate beneath the indenter. As the height of the axial wall increases, loads to cause failure increase linearly. In crowns with variation in axial wall height around the periphery, stresses concentrate both beneath the indenter and at the margin of the core ceramic. The magnitude of the stress concentration at the margin is directly related to the amount of variation in axial wall height around the periphery of the crown. Anatomically correct veneered zirconia core crowns subjected to single-cycle loads, fracture in areas of greatest stress concentration identified by finite element models. Fractures and stress concentrations that occur in response to single-cycle loading are important indicators of initiation sites for fatigue failure. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009.

Fracture Modes in Curved Brittle Layers Subject to Concentrated Cyclic Loading in Liquid Environments.

Damage response of brittle curved structures subject to cyclic Hertzian indentation was investigated. Specimens were fabricated by bisecting cylindrical quartz glass hollow tubes. The resulting hemi-cylindrical glass shells were bonded internally and at the edges to polymeric supporting structures and loaded axially in water on the outer circumference with a spherical tungsten carbide indenter. Critical loads and number of cycles to initiate and propagate near-contact cone cracks and far-field flexure radial cracks to failure were recorded. Flat quartz glass plates on polymer substrates were tested as a control group. Our findings showed that cone cracks form at lower loads, and can propagate through the quartz layer to the quartz/polymer interface at lower number of cycles, in the curved specimens relative to their flat counterparts. Flexural radial cracks require a higher load to initiate in the curved specimens relative to flat structures. These radial cracks can propagate rapidly to the margins, the flat edges of the bisecting plane, under cyclic loading at relatively low loads, owing to mechanical fatigue and a greater spatial range of tensile stresses in curved structures.

MicroCT analysis of hydroxyapatite bone repair scaffolds created via three-dimensional printing for evaluating the effects of scaffold architecture on bone ingrowth.

Recent studies have shown that it is now possible to construct tissue-engineered bone repair scaffolds with tight pore size distributions and controlled geometries using 3-D Printing techniques (3DP). This study evaluated two hydroxyapatite (HA) 8-mm diameter discs with controlled architectures in a rabbit trephine defect at 8 and 16 weeks using a 2 x 2 factorial design. Input parameters were time and scaffold void volume at two levels. Three output variables were extracted from MicroCT data: bone volume ingrowth with respect to total region of interest, bone volume ingrowth with respect to available ingrowth volume, and soft tissue volume. The experiment measured two groups--Group 1: 500-microm x 500-microm channels parallel to the scaffold's long axis and penetrating up 3-mm from the bottom. Group 2: 800-microm x 800-microm struts spaced 500 microm apart set perpendicularly to each other in each printed layer. Rendered 3-dimensional MicroCT scans and undecalcified histological slides of implants revealed good integration with the surrounding tissue, and a sizeable amount of bone ingrowth into the device. Factorial analysis revealed that the effects of time were the greatest determinant of soft tissue ingrowth, while time and its interaction with void volume were the greatest determinants of bone volume ingrowth with respect to both total and available volume.

All hazards training: incorporating a catastrophe preparedness mindset into the dental school curriculum and professional practice.

Catastrophic preparedness should be incorporated into the dental school curriculum. The experience at New York University College of Dentistry is that a combination of catastrophic preparedness elements integrated within existing courses with a short, meaningful capstone course dedicated to all hazards preparedness can be accomplished successfully and meet proposed competencies for training in the dental curriculum. The roles and responsibilities in catastrophic response preparedness and response of dentists are actively being discussed by the dental profession. An element of that discussion has to include the "what" and "how" of education and training for dentists at the predoctoral level and after dental school graduation. The concepts presented in this article should be debated at all levels of the profession.

In vivo bone response to 3D periodic hydroxyapatite scaffolds assembled by direct ink writing.

The in vivo bone response of 3D periodic hydroxyapatite (HA) scaffolds is investigated. Two groups of HA scaffolds (11 mm diameter x 3.5 mm thick) are fabricated by direct-write assembly of a concentrated HA ink. The scaffolds consist of cylindrical rods periodically arranged into four quadrants with varying separation distances between rods. In the first group, HA rods (250 microm in diameter) are patterned to create pore channels, whose areal dimensions are 250 x 250 microm(2) in quadrant 1, 250 x 500 microm(2) in quadrants 2 and 4, and 500 x 500 microm(2) in quadrant 3. In the second group, HA rods (400 microm in diameter) are patterned to create pore channels, whose areal dimensions of 500 x 500 microm(2) in quadrant 1, 500 x 750 microm(2) in quadrants 2 and 4, and 750 x 750 microm(2) in quadrant 3. Each group of scaffolds is partially densified by sintering at 1200 degrees C prior to being implanted bilaterally in trephine defects of skeletally mature New Zealand White rabbits. Their tissue response is evaluated at 8 and 16 weeks using micro-computed tomography, histology, and scanning electron microscopy. New trabecular bone is conducted rapidly and efficiently across substantial distances within these patterned 3D HA scaffolds. Our observations suggest that HA rods are first coated with a layer of new bone followed by subsequent scaffold infilling via outward and inward radial growth of the coated regions. Direct-write assembly of 3D periodic scaffolds composed of micro-porous HA rods arrayed to produce macro-pores that are size-matched to trabecular bone may represent an optimal strategy for bone repair and replacement structures.

Computer-aided design and fabrication of dental restorations: current systems and future possibilities.

BACKGROUND: For more than 20 years, researchers have been trying to automate conventional manual processes in dental technology with the hope of producing higher- and more uniform-quality materials, standardizing manufacturing processes and reducing production costs. METHODS: The authors review existing computer-aided design (CAD)/computer-aided manufacturing (CAM) systems, describing the components of CAD/CAM technologies and addressing the limitations of current systems, and suggest possibilities for future systems. CONCLUSIONS: Existing dental CAD/CAM systems vary dramatically in their capabilities; each has distinct advantages and limitations. None can yet acquire data directly in the mouth and produce the full spectrum of restoration types (with the breadth of material choices) that can be created by traditional techniques. Emerging technologies may expand dramatically the capabilities of future systems, but they also may require a different type of training to use them to their full effectiveness. CLINICAL IMPLICATIONS: In the future, automatically fabricated, fully esthetic restorations might be produced more quickly and have longer lifetimes than restorations currently produced with CAD/CAM systems.

Proposed educational objectives for hospital-based dentists during catastrophic events and disaster response.

The purpose of this project was to define education and training requirements for hospital-based dentists to efficiently and meaningfully participate in a hospital disaster response. Eight dental faculty with hospital-based training and/or military command and CBRNE (chemical, biological, radiological, nuclear, and explosive) expertise were recruited as an expert panel. A consensus set of recommended educational objectives for hospital-based dentists was established using the following process: 1) identify assumptions supported by all expert panelists, 2) determine current advanced dental educational training requirements, and 3) conduct additional training and literature review by various panelists and discussions with other content and systems experts. Using this three-step process, educational objectives that the development group believed necessary for hospital-based dentists to be effective in treatment or management roles in times of a catastrophic event were established. These educational objectives are categorized into five thematic areas: 1) disaster systems, 2) triage/medical assessment, 3) blast and burn injuries, 4) chemical agents, and 5) biological agents. Creation of training programs to help dentists acquire these educational objectives would benefit hospital-based dental training programs and strengthen hospital surge manpower needs. The proposed educational objectives are designed to stimulate discussion and debate among dental, medical, and public health professionals about the roles of dentists in meeting hospital surge manpower needs.

The Medical Reserve Corps. an opportunity for dentists to serve.

The response to the events of Sept. 11, 2001, relied on local resources and personnel. Aware of how important their contribution could be, many people are now inspired to volunteer during times of crisis. The Medical Reserve Corps is a community-based volunteer network of health professionals that trains to respond to large-scale emergencies.

Introducing a senior course on catastrophe preparedness into the dental school curriculum.

This article describes an integrated fourth-year course in catastrophe preparedness for students at the New York University College of Dentistry (NYUCD). The curriculum is built around the competencies proposed in "Predoctoral Dental School Curriculum for Catastrophe Preparedness," published in the August 2004 Journal of Dental Education. We highlight our experience developing the program and offer suggestions to other dental schools considering adding bioterrorism studies to their curriculum.

Factorial analysis of variables influencing stress in all-ceramic crowns.

OBJECTIVE: The objective of this investigation was to evaluate the relative contribution of variables in the crown-cement-tooth system that can influence magnitude of maximum principal stress in all-ceramic crowns. METHODS.: Factorial analysis was performed to calculate the coefficients of main and interactive effects of seven variables on maximum stress distribution in a series of finite element models of an axisymmetric stylized ceramic crown-cement-tooth system. Variables investigated at two levels were selected for their clinical relevance and included those relating to crown material and geometry (thickness and cuspal incline), cement modulus and thickness, supporting tooth core, and position at which the occlusal load was applied. RESULTS: The average principal stress for all combinations of all variables was 135.1 MPa but stress magnitude ranged from 73.7 to 214.0 MPa. Crown material and thickness are of primary importance in stress magnitude but other variables (cement modulus, load position, and supporting tooth core) also contribute to the stress magnitude. Interactions between these variables can have an important influence, particularly since the stress in the crown is not necessarily sensitive to the same factors for all crown material systems. SIGNIFICANCE: Comprehensive evaluation of stress in a crown of a crown-cement-tooth system must integrate the influence of single variables and their interactions.

Damage accumulation and fatigue life of particle-abraded ceramics.

PURPOSE: This investigation compared initial and fatigue strengths of particle-abraded ceramics to those of as-polished alumina and zirconia ceramics in crown-like layer structures. MATERIALS AND METHODS: Alumina or zirconia plates bonded to polycarbonate substrates were subjected to single-cycle and multi-cycle contact (fatigue) loading. Cementation surfaces of the ceramic were damaged by controlled particle abrasion, indentation with a sharp diamond at low load, or a blunt indenter at high load. The stresses needed to initiate radial fractures were evaluated. RESULTS: The strengths of specimens were lowered by fatigue loading. After the equivalent of 1 year of occlusal contacts, the strengths of undamaged specimens degraded to approximately half of their single-cycle values. In particle-abraded specimens, an additional 20% to 30% drop in strength occurred after several hundred load cycles. Particle abrasion damage was approximately equivalent to damage from sharp indentation at low load or blunt indentation at high load. CONCLUSION: Damage from particle abrasion, not necessarily immediately apparent, compromised the fatigue strength of zirconia and alumina ceramics in crown-like structures. In fatigue, small flaws introduced by particle abrasion can outweigh any countervailing strengthening effect from compression associated with surface damage or, in the case of zirconia, with phase transformation.