ABSTRACT
In experiments on hyperlipidemic rats it was observed the hypolipidemic effect of new sulfated polisaccharides-chitosan, lutelan and krilan sulfates, More pronounced decrease was established in VLDL and increase of HDL after sulfated polysaccharides treatment. The most distinct efficiency exhibites preparation with moledular mass of 20-40 x 10(3) D and the rate of sulfation 9-14%.
Subject(s)
Hyperlipidemias/prevention & control , Hypolipidemic Agents/pharmacology , Lipoproteins/blood , Polysaccharides/pharmacology , Animals , Chitin/analogs & derivatives , Chitin/pharmacology , Chitin/toxicity , Chitosan , Detergents/toxicity , Hyperlipidemias/chemically induced , Hypolipidemic Agents/toxicity , Lethal Dose 50 , Male , Mice , Polyethylene Glycols/toxicity , Polysaccharides/toxicity , Rats , Sulfates/pharmacology , Sulfates/toxicity , UltracentrifugationABSTRACT
In vitro experiments were shown that native ecologically pure non-starch polysaccharide crylan bind the bile acid. Crylan was found to decrease hyperlipidemia induced in rats by means of diet enriched with cholesterol and 6-methylthiouracil. This effect of crylan was more pronounced as compare with the action of native nonspecific enterosorbent polyfepan.
Subject(s)
Hyperlipidemias/drug therapy , Hypolipidemic Agents/therapeutic use , Polysaccharides/therapeutic use , Animals , Antithyroid Agents/administration & dosage , Cholesterol, Dietary/administration & dosage , Diet, Atherogenic , Enterosorption , Hyperlipidemias/etiology , Lignin/administration & dosage , Lipids/analysis , Lipids/blood , Liver/chemistry , Male , Methylthiouracil/administration & dosage , RatsABSTRACT
Experiments on rats, guinea pigs and rabbits with hyperlipidemia induced by high-cholesterol diet have revealed that the specific antihypoxic drug oliphen has hypolipidemic effect which is least pronounced in oral GABA. Oliphen causes a significant increase in alpha-cholesterol (antiatherogenic lipoprotein cholesterol) decreased by hyperlipidemia. It is suggested that oliphen improves hepatic receptor-dependent uptake and atherogenic lipoprotein degradation.
Subject(s)
Hyperlipidemias/drug therapy , Hypolipidemic Agents/therapeutic use , gamma-Aminobutyric Acid/therapeutic use , Animals , Cholesterol, Dietary/administration & dosage , Clofibrate/therapeutic use , Drug Evaluation, Preclinical , Guinea Pigs , Hyperlipidemias/blood , Hyperlipidemias/etiology , Lipids/blood , Male , Rabbits , RatsABSTRACT
In-vitro experiments have shown that dietary fibre microcrystalline cellulose and lignin (polyphepan) possess high activity in binding sodium salt of cholic acid. This action is comparable with that of pectin and metamucile. Hypolipidemic effect of microcrystalline cellulose, polyphepan and synthetic enterosorbents carbonates was also seen in hyperlipidemic rats. It is concluded that microcrystalline cellulose and polyphepan hold promise as a dietary supplement for hyperlipidemic patients.
Subject(s)
Enterosorption/methods , Hyperlipidemias/therapy , Animals , Cholesterol/blood , Evaluation Studies as Topic , Hyperlipidemias/blood , Male , Rats , Triglycerides/bloodSubject(s)
Arteriosclerosis/therapy , Carbonates/administration & dosage , Dietary Fiber/administration & dosage , Disease Models, Animal , Enterosorption/methods , Hyperlipidemias/therapy , Adult , Animals , Arteriosclerosis/metabolism , Arteriosclerosis/prevention & control , Combined Modality Therapy , Female , Humans , Hyperlipidemias/metabolism , Hyperlipidemias/prevention & control , Lipid Metabolism , Male , Middle Aged , Papio , RatsABSTRACT
The bile acid sequestering agent Vasosan P is a new form of pectin-enriched cholestyramine (20%), saccharose (5%) and sorbic acid (0.18%). In comparison with cholestyramine Vasosan P has a more marked hypolipidemic effect in experiment. Vasosan P is remarkable for good organoleptic properties. It is effective in treating patients with type IIa hyperlipoproteinemia and practically has no side effects as cholestyramine.
