Neuronal representation of bimanual arm motor imagery in the motor cortex of a tetraplegia human, a pilot study.

Introduction: How the human brain coordinates bimanual movements is not well-established. Methods: Here, we recorded neural signals from a paralyzed individual's left motor cortex during both unimanual and bimanual motor imagery tasks and quantified the representational interaction between arms by analyzing the tuning parameters of each neuron. Results: We found a similar proportion of neurons preferring each arm during unimanual movements, however, when switching to bimanual movements, the proportion of contralateral preference increased to 71.8%, indicating contralateral lateralization. We also observed a decorrelation process for each arm's representation across the unimanual and bimanual tasks. We further confined that these changes in bilateral relationships are mainly caused by the alteration of tuning parameters, such as the increased bilateral preferred direction (PD) shifts and the significant suppression in bilateral modulation depths (MDs), especially the ipsilateral side. Discussion: These results contribute to the knowledge of bimanual coordination and thus the design of cutting-edge bimanual brain-computer interfaces.

Dynamic Ensemble Bayesian Filter for Robust Control of a Human Brain-Machine Interface.

OBJECTIVE: Brain-machine interfaces (BMIs) aim to provide direct brain control of devices such as prostheses and computer cursors, which have demonstrated great potential for motor restoration. One major limitation of current BMIs lies in the unstable performance due to the variability of neural signals, especially in online control, which seriously hinders the clinical availability of BMIs. METHOD: We propose a dynamic ensemble Bayesian filter (DyEnsemble) to deal with the neural variability in online BMI control. Unlike most existing approaches using fixed models, DyEnsemble learns a pool of models that contains diverse abilities in describing the neural functions. In each time slot, it dynamically weights and assembles the models according to the neural signals in a Bayesian framework. In this way, DyEnsemble copes with variability in signals and improves the robustness of online control. RESULTS: Online BMI experiments with a human participant demonstrate that, compared with the velocity Kalman filter, DyEnsemble significantly improves the control accuracy (increases the success rate by 13.9% in the random target pursuit task) and robustness (performs more stably over different experiment days). CONCLUSION: Experimental results demonstrate the superiority of DyEnsemble in online BMI control. SIGNIFICANCE: DyEnsemble frames a novel and flexible dynamic decoding framework for robust BMIs, beneficial to various neural decoding applications.

Epileptic Focus Localization via Brain Network Analysis on Riemannian Manifolds.

OBJECTIVE: Brain network connectivity analysis plays an important role in computer-aided automatic localization of seizure onset zone (SOZ) from Intracranial Electroencephalography (iEEG). However, how to accurately compute brain network dynamics is still not well addressed. This work aims to develop an effective measure to find out the dynamics for SOZ localization. METHODS: Given multiple-channel iEEG signals, the ictal process involves continuous changes of information propagation. In each time slot, the connectivity relationship between channels can be represented as a matrix. Since the matrices from different time slots do not lie on vector spaces, the similarity between them cannot be computed directly. In this paper, we regard the matrices as points on a Riemannian manifold, so that the similarity can be measured by the geodesic distance on the manifold. It addresses the information-losing problem in existing methods using a vector to approximate a matrix. With the Riemannian method, the brain network dynamics are figured out by clustering methods. A temporal segmentation process is applied to refine the segments for SOZ localization. RESULTS: Our method is evaluated on six epilepsy patients, and the SOZ localization performance is evaluated by the area under the curve (AUC) score. Overall, our method obtains an average AUC score of 0.875, which outperforms the existing approaches. CONCLUSION: Our method preserves more information in measuring the relationship between brain connectivity descriptors, thus is more robust for SOZ localization. SIGNIFICANCE: Our method has great potentials for clinical epilepsy treatments.