[Assessment of nasal specific symptoms and psychological dysfunction in patients with chronic rhinosinusitis before and after surgery].

Objective:To investigate the effects of nasal specific symptoms on chronic rhinosinusitis（CRS） with anxiety, depression and other psychological dysfunction and endoscopic surgery for the improvement of psychological dysfunction in patients with CRS. Method:The Hamilton Anxiety Scale（HAMA）, Hamilton Depression Scale（HAMD） and the 22-Item Sino-Nasal Outcome Test（SNOT-22） were completed in 44 patients with CRS within one week before and 6 months after surgery. They were used to assess mental function and nasal specific symptoms. Result:According to the SNOT-22 score, patients with anxiety and depression mental dysfunction had more severe symptoms of dizziness, head and face pain and sleep disorders（P<0.01 or P<0.05）. After endoscopic sinus surgery, the scores of HAMD, HAMA and SNOT-22 in CRS patients were improved compared with preoperative（P<0.01）. Conclusion:Patients with CRS have more common anxiety and depression. The specific symptoms of dizziness and head and face pain are significantly related to the psychological dysfunction of patients with CRS. Endoscopic sinus surgery can significantly alleviate the specific symptoms and mental dysfunction.

[The influence of allergic rhinitis on negative emotion].

OBJECTIVE: To investigate the influence of allergic rhinitis on negative emotion. METHOD: One hundred and ninety cases with allergic rhinitis as observer group were investigated by state-trait anxiety inventory (STAI) and self-rating depressive scale (SDS). According to pathogenetic condition, patients were divided into persistent allergic rhinitis 71 cases (A group) and intermittent allergic rhinitis 119 cases (B group). Meanwhile, 190 healthy persons as control group were compared with observer group. RESULT: (1) The main allergens of allergic rhinitis were dermatophagoides pteronyssinus, dermatophagoides farina, pollen, and epiphyte, which the skin index was above "++" by skin prick test. (2) The state anxiety score of observer group (42.17±16.21) was significantly higher than control group (38.78±16.54), t=2.02, P<0.05. There were no difference in trait anxiety between observer group and control group (41.25±16.16 vs. 41.19±16.84), P>0.05. The anxiety scores of female in A and B groups were higher than that of female in control group (43.77±15.76, 42.93±15.58 vs 38.44±15.71), P<0.05. (3) The score of SDS in A and B group was significantly higher than that of control group (37.78±9.22, 39.65±9.87 vs 35.24±7.81), P<0.01. The rate of depression in observer group (11.6%, 22/190) was significantly higher than that of control group (2.6%, 5/190), Χ2=11.52, P<0.01. CONCLUSION: The allergic rhinitis may cause patients anxiety and depression, especially for female, but patients with allergic rhinitis have no significant trait anxiety.

[Influence of nasal septal deviation on incidence of bilateral sinusitis].

OBJECTIVE: To investigate the influence of nasal septal deviation on the incidence of bilateral sinusitis. METHOD: Two thousand and seventy-four cases of nasal septal deviation with chronic sinusitis available from January 2006 to March 2012 were reviewed retrospectively. RESULT: Of these 2074 cases, 1 687 (81.3%) patients had sinusitis in narrow side and 1582 (76.3%) in wide side, the difference was statistically significant (P < 0.01) and the relative risk value in narrow side (1.4) was higher than wide side (0.7) associated with the incidence of sinusitis. There was significant difference (P < 0.05) between the two group counting datas analyzed by rank sum test, and the mean rank order in narrow side was 1656.396, significantly greater than wide side (1 612.184). The incidence of sinusitis in men was 50.6% (1049/2074), in women was 49.4% (1025/2074), and there was no significant difference between them. Deviating leftward was 1148 cases (55.4%), deviating rightward was 926 cases (44.6%), and the difference was statistically significant (P < 0.05). Anatomic variations in narrow side and wide side were uncinate process hypertrophy (7.0%, 27.0%), middle turbinate hypertrophy (7.8%,38.0%), ethmoidal bulla hypertrophy (26.2%, 39.0%), paradoxical middle turbinate (5.4%, 15.5%), hypertrophic inferior turbinate (52.9%, 67.0%) and mucosa pachynsis (0.5%, 2.8%), respectively. CONCLUSION: Sinusitis incidence in narrow side is higher than wide side. There is no significant difference between the incidence of sinusitis in men and women. The majority of nasal septum deviate leftward. Higher incidence of sinusitis in wide side is the result of compensatory mechanism. Only septoplasty may not restore the normal venting function in nasal cavity. Hypertrophic inferior turbinate are closely correlated with sinusitis.

[Clinical study of 34 patients with extranodal NK/T cell lymphoma-nasal type].

OBJECTIVE: To explore the clinical feature, the reason of misdiagnosis and mistreatment, influential factor of prognosis in patients with extranodal NK/T cell lymphoma-nasal type. METHOD: A retrospective study was made on the clinical data of 34 patients with extranodal NK/T cell lymphoma-nasal type. Among them, 10 cases were staged I(E) intra-cavity, 15 cases were I(E) ex-cavity, 6 cases were II(E) and 3 cases were IV(E). Among them, 29 cases were in nasal cavity, 5 cases were outside nasal cavity; 14 cases were treated with single chemotherapy or radiation therapy, 20 cases were treated with radiation therapy add chemotherapy. RESULT: The total rate of misdiagnosis and mistreatment were 58.8% (20/34), 52.3% (18/34), respectively. The 5-year survival rate of the I(E) intra-cavity group were 60.0% (6/10), and those of I(E) ex-cavity group were 26.7% (4/15), and those of II(E) group and IV(E) group were 16.7% (1/6), 0% (0/3), respectively There was significant difference between 3 groups by statistical analysis (P < 0.01). The 5-year survival rate of I(E) ex-cavity group treated with single therapy were 0% (0/6), and those of I(E)-cavity group treated with combined therapy were 50% (1/2). CONCLUSION: The early clinical manifestation of extranodal NK/T tell lymphoma-nasal type is atypical and which is hard to diagnose and treat. Diagnosis depends on pathologic biopsy and immunohistochemistry, there are many factors that influence the prognosis of this disease, in which the clinical stage is a major factor. It is crucial for diagnosing and treating early.

[A clinical observation on the effect of irrigating solution of Shuang Huang Lian on ESS for chronic sinusitis].

OBJECTIVE: To investigate the effect of irrigating solution of Shuang Huang Lian on ESS for chronic sinusitis. METHOD: In 201 cases with chronic sinusitis (type II) treated by ESS From August 2001 to August 2004, the Shuang Huang Lian Liquid and 0.9% N.S. were respectively used in 101 cases and 100 cases to irrigate the operated sinus cavity, then a comparison was made between the two groups about the irrigating solution with above six months followed up. RESULT: The total effective ratio in group Shuang Huang Lian was significantly higher than that in group of 0.9% N.S. (P < 0.05). CONCLUSION: Irrigating solution of Shuang Huang Lian used after operation can improve the therapeutic effect of ESS for chronic sinusitis.