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1.
Opt Lett ; 49(10): 2685-2688, 2024 May 15.
Article in English | MEDLINE | ID: mdl-38748136

ABSTRACT

Compact light couplers between III-V devices and Si waveguides are crucial for advancing the scalability of Si photonics. Here, we present a compact light coupling strategy for lateral III-V membrane lasers and PDs directly grown on SOI platforms. Benefiting from the coplanar configuration of epitaxial III-V membranes and Si device layer, we designed novel, to our knowledge, butt couplers to achieve both small footprint and high efficiency coupling. We employed sub-wavelength grating structures to gradually bridge the effective refractive index between the III-V membranes and Si waveguide and obtained a coupling loss of less than 0.5 dB across the entire telecom band in a length of less than 10 µm. Our work here offers a fresh perspective for future densely integrated Si photonics.

2.
Mitochondrial DNA B Resour ; 7(4): 683-685, 2022.
Article in English | MEDLINE | ID: mdl-35478861

ABSTRACT

Plastid genomes are useful markers in resolving plant phylogenetic relationships for various taxonomic groups. Here, we sequenced and de novo assembled the complete plastid genome sequence of an Antarctic moss Chorisodontium aciphyllum (Hook. f. & Wilson) Broth using genome skimming data. The newly generated plastid genome is conserved in structure and gene content compared with that of other Bryopsida. Plastid phylogenetic analysis of mosses recovered a robust phylogeny in which Chorisodontium aciphyllum clustered with Fissidens nobilis from the Dicranales. The plastid genome sequence of C. aciphyllum will aid future evolution and diversification studies of land plants.

3.
J Nat Prod ; 83(6): 1766-1777, 2020 06 26.
Article in English | MEDLINE | ID: mdl-32479076

ABSTRACT

Fourteen new terpenoids plagicosins A-N (1-14), including seven sesquiterpenoids (1-7) consisting of six ent-bicyclogermacrenes and one ent-2,3-seco-aromadendrane, as well as seven diterpenoids (8-14) comprising five fusicoccanes, a eunicellane, and a rare gersemiane, were isolated from the Chinese liverwort Plagiochila fruticosa Mitt. The structures of these terpenoids were determined on the basis of comprehensive analysis of MS and NMR spectroscopic data coupled with electronic circular dichroism (ECD) and coupling constant calculations. Plagicosin F (6) displayed potent antivirulence activity through inhibiting the hyphal morphogenesis, adhesion, and biofilm formation of Candida albicans. The genes related to hyphal formation were regulated by 6.


Subject(s)
Antifungal Agents/pharmacology , Candida albicans/drug effects , Hepatophyta/chemistry , Terpenes/pharmacology , Biofilms/drug effects , Circular Dichroism , Diterpenes/chemistry , Hyphae/drug effects , Hyphae/growth & development , Magnetic Resonance Spectroscopy , Mass Spectrometry , Molecular Structure , Sesquiterpenes/chemistry , Terpenes/chemistry , Virulence/drug effects
4.
Phytochemistry ; 158: 77-85, 2019 Feb.
Article in English | MEDLINE | ID: mdl-30476899

ABSTRACT

Six previously undescribed labdane diterpenoids, frullanians A-F, along with five known diterpenoids, were isolated from the Chinese liverwort Frullania hamatiloba Stephani. Their structures were determined using NMR data, electronic circular dichroism (ECD) calculations as well as the single crystal X-ray diffraction measurement. NAD(P)H: QR (quinone reductase) assay demonstrated that frullanian D and four known compounds displayed antioxidant effect mediated via Nrf2 (Nuclear factor-erythroid 2-related factor 2) induction. Further investigation of the most bioactive frullanian D in MOVAS cells revealed that it ameliorated H2O2-induced oxidative insults without toxicity by increasing cell viability, attenuating morphological changes, and reducing intracellular ROS production. In addition, frullanian D promoted the nuclear translocation of Nrf2 and upregulated the expressions of antioxidant proteins NQO1 (NAD(P)H quinone oxidoreductase 1) and γ-GCS (γ-glutamyl cysteine synthetase). Docking analysis using MOE software further supported the activation of the Nrf2 pathway by frullanian D.


Subject(s)
Antioxidants/pharmacology , Diterpenes/pharmacology , Frullania/chemistry , NF-E2-Related Factor 2/metabolism , Animals , Antioxidants/administration & dosage , Antioxidants/chemistry , Cell Line , Circular Dichroism , Crystallography, X-Ray , Diterpenes/administration & dosage , Diterpenes/chemistry , Drug Evaluation, Preclinical/methods , Hydrogen Peroxide/toxicity , Magnetic Resonance Spectroscopy , Mice , Molecular Docking Simulation , Molecular Structure , NAD(P)H Dehydrogenase (Quinone)/metabolism , Oxidative Stress/drug effects , Signal Transduction/drug effects
5.
Bioorg Med Chem ; 26(9): 2392-2400, 2018 05 15.
Article in English | MEDLINE | ID: mdl-29655613

ABSTRACT

Five new terpenoids (1-5) including two dollabellane-type, one ent-kaurane-type diterpenoids and two sesquiterpenoids were isolated from the Chinese liverwort Lepidozia reptans (L.) Dumort., together with nine known terpenoids (6-14). Their structures were determined on the basis of analysis of MS and NMR spectroscopic data, single-crystal X-ray diffraction and electronic circular dichroism calculations. The selected compounds 1, 2, 6, 7, 9 and 14 were screened for anti-inflammatory activities by the model of LPS-induced nitric oxide (NO) production with macrophage cells, and the mechanism of the active compounds 1 and 2 were further explored.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Diterpenes, Kaurane/pharmacology , Sesquiterpenes/pharmacology , Animals , Anti-Inflammatory Agents, Non-Steroidal/chemistry , Anti-Inflammatory Agents, Non-Steroidal/isolation & purification , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism , Cyclooxygenase 2/metabolism , Diterpenes, Kaurane/chemistry , Diterpenes, Kaurane/isolation & purification , Hepatophyta/chemistry , Interleukin-6/genetics , Interleukin-6/metabolism , Mice , NF-kappa B/metabolism , Nitric Oxide/metabolism , RAW 264.7 Cells/metabolism , RNA, Messenger/genetics , Sesquiterpenes/chemical synthesis , Sesquiterpenes/isolation & purification , Tumor Necrosis Factor-alpha/genetics , Tumor Necrosis Factor-alpha/metabolism
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