ABSTRACT
In a randomized, double-blind, two-way crossover study in four centers, 124 patients received single doses of 4 or 6 mg of albuterol and placebo on two separate visits. Pulmonary function tests were performed at intervals up to ten hours. Both dosages produced peak bronchodilation responses which occurred at two hours and significant activity was maintained for at least eight hours. Adverse experiences were typical of adrenergic agents.
Subject(s)
Albuterol/administration & dosage , Asthma/drug therapy , Administration, Oral , Adolescent , Adult , Albuterol/adverse effects , Bronchial Spasm/drug therapy , Child , Clinical Trials as Topic , Dose-Response Relationship, Drug , Double-Blind Method , Female , Forced Expiratory Volume , Humans , Male , Middle AgedABSTRACT
Twenty-seven volunteers with grass-pollen allergy who had not received prior immunotherapy had titrated prick tests with fivefold dilutions of 10 grasses (timothy, Bermuda, smooth brome, grama, salt, quack, western wheat, Johnson, June, and Bahia) to a final dilution of 1:3,906,250 w/v. Ten subjects served as untreated control subjects. Seventeen subjects received immunotherapy with an extract containing equal parts of timothy and Bermuda. Twelve months later subjects had repeat titrated skin testing with reconstituted aliquots of the same lyophilized extract, at the same time of day, and at the same location on the back as in the initial testing period. Nine treated subjects and eight control subjects completed the study protocol. The skin test areas with all 10 grass extracts were significantly decreased in the treated group compared to the control group (p less than 0.01), and there was no difference in the extent of the reduction among the 10 grasses by analysis of variance. We conclude that immunotherapy to timothy and Bermuda alone is capable of reducing to a similar degree the clinical sensitivity to all 10 grasses studied. The results of this study suggest that treatment with timothy and Bermuda alone may be sufficient in most grass-sensitive individuals.
Subject(s)
Allergens/immunology , Poaceae/immunology , Antibodies/analysis , Binding, Competitive , Cross Reactions , Humans , Immunoglobulin E/analysis , Immunotherapy , Radioallergosorbent Test , Skin TestsABSTRACT
Interest in increased patient education regarding medications they receive is gathering momentum. An historical overview is provided as well as summaries of available patient information resources. To date little such information has been available for patients receiving immunotherapy with allergen extracts. A comprehensive draft monograph driven from multiple sources for the various products available is proposed, as well as suggested advice for patients. Comments and suggestions for revision are solicited, prior to proposed inclusion in a national patient information publication.
Subject(s)
Allergens , Allergens/administration & dosage , Allergens/adverse effects , Allergens/pharmacology , Anaphylaxis/etiology , Breast Feeding , Cross Reactions , Diagnostic Errors , Drug Interactions , Drug Storage , Female , Histamine Release , Humans , Hypersensitivity/immunology , Immunotherapy , Infusions, Parenteral , Patient Education as Topic , Pregnancy , Pregnancy Complications/immunologyABSTRACT
The effect singly and in combination of methylprednisolone and troleandomycin (TAO) on methacholine sensitivity was studied in eight mildly asthmatic patients who did not require regular bronchodilator therapy. Neither drug alone nor in combination significantly altered the bronchial reactivity to methacholine.
