ABSTRACT
A 50-year-old man visited his family physician one day after he had felt something entering his left eye following the blow of a metal hammer on metal, after which he began to see black spots. After the eye had been occluded for 4 days, his visual acuity had decreased to 0.1. Ophthalmologic examination revealed a defect in the cornea and iris, a foreign body in the vitreous and local cataract. Following surgical removal of the metal splinter and the lens, the visual acuity was restored to 0.8. Implantation of an artificial lens was planned. Ocular trauma is a major cause of permanent visual loss or blindness in (young) adults in the western world. Traumas in which a foreign body is propelled into the eye with high energy are most likely to penetrate the sclera. Damage and complications due to intraocular foreign bodies may lead to loss ofvision. The entry site of an intraocular foreign body may be difficult to find and the diagnosis may be missed. Therefore, an ophthalmologist should be consulted in case of a high-energy trauma in combination with visual loss.
Subject(s)
Eye Foreign Bodies/complications , Eye Injuries, Penetrating/complications , Lens Implantation, Intraocular/methods , Vision, Low/etiology , Eye Foreign Bodies/surgery , Eye Injuries, Penetrating/surgery , Humans , Male , Middle Aged , Treatment Outcome , Vision, Low/surgery , Vitrectomy/methodsABSTRACT
Congenital grouped pigmentation of the retina is an uncommon disorder characterized by a grouping together of round to oval spots of pigment in one or more quadrants of the retina, except for the macula. Detection is usually coincidental during routine ocular examination. We examined a mother and daughter with bilateral grouped pigmentation of the retina. Visual acuity, visual fields, and results of electrophysiologic examination were normal. Autosomal dominant inheritance with variable expression was likely.
Subject(s)
Retinitis Pigmentosa/congenital , Adult , Child, Preschool , Female , Fluorescein Angiography , Fundus Oculi , Humans , Pedigree , Retinitis Pigmentosa/genetics , Visual AcuityABSTRACT
Presently used animal models of proliferative vitreoretinopathy reflect only cell proliferation and contraction. We used an in vitro model that measured cell migration, proliferation, and contraction. The following four drugs were assayed on this system: daunomycin, taxol, colchicine, and cytochalasin B. Daunomycin was the most effective drug against cell proliferation and cell migration but had no effect on cell contraction; taxol and colchicine affected all three parameters. Cytochalasin B was the least effective drug tested.
Subject(s)
Retina/pathology , Retinal Diseases/pathology , Alkaloids/pharmacology , Animals , Cell Division/drug effects , Cells, Cultured , Chemotaxis/drug effects , Colchicine/pharmacology , Cytochalasin B/pharmacology , Daunorubicin/pharmacology , Fibroblasts/cytology , Fibroblasts/drug effects , Fibroblasts/physiology , Paclitaxel , Rabbits , Retinal Diseases/physiopathology , Skin/cytologyABSTRACT
This study demonstrates in a rabbit model of epiretinal membrane formation that retinal-associated ODC activity increases during this pathological process. These changes in retinal-associated ODC activity most likely occur in relationship to the proliferative lesion itself, since the retina consists primarily of nonproliferative tissues. Further knowledge of intraocular polyamine metabolism during epiretinal membrane formation which can result in retinal detachment may lead to the development of an effective pharmacological treatment.
