ABSTRACT
BACKGROUND: Neuropsychiatric symptoms (NPS) are a common aspect of Alzheimer's disease (AD). Multiple studies have investigated its brain correlates, but it still remains unclear how they relate with brain atrophy in mild cognitive impairment (MCI). OBJECTIVE: Our objective was to investigate brain volume in MCI patients as a function of NPS. METHODS: We measured grey matter volume, neuropsychological status and NPS (Neuropsychiatric Inventory, NPI), in a sample of 81 MCI patients (43 females). Participants were divided in groups depending on presence (NPS+) or absence (NPS-) of NPS and on type of NPS. RESULTS: We found lower volume of left temporal pole in patients with depression compared to NPS- (pâ=â0.012), and in patients with agitation compared to NPS- in the right middle occipital gyrus (pâ=â0.003). We also found a significant correlation between volume of left temporal pole and MMSE (r (78) â=â0.232, pâ=â0.019). Finally, NPS+ presented lower cross-sectional cognitive level than NPS- (t (79) â=â1.79, pâ=â0.038), and faster cognitive decline (t (48) â=â-1.74, pâ=â0.044). CONCLUSIONS: Our results support the colocalization of structural damage as a possible mechanism underlying the relationship between MCI and depression and provide novel evidence regarding agitation. Moreover, our longitudinal evidence highlights the relevance of an adequate identification of NPS in MCI patients to identify those at risk of faster cognitive decline.
Subject(s)
Alzheimer Disease , Cognitive Dysfunction , Female , Humans , Depression/diagnostic imaging , Cross-Sectional Studies , Cognitive Dysfunction/diagnosis , Alzheimer Disease/pathology , Brain/diagnostic imaging , Brain/pathology , Atrophy/pathology , Neuropsychological Tests , Magnetic Resonance Imaging/methodsABSTRACT
Letter to the editor.
Carta al editor.
Subject(s)
Cocaine-Related Disorders/surgery , Nucleus Accumbens/surgery , Adult , Cocaine-Related Disorders/psychology , Humans , Male , Motivation , Neurosurgical Procedures , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Humans , Male , Adolescent , Translational Research, Biomedical , Nucleus Accumbens/physiopathology , Cocaine-Related Disorders/diagnosis , Cocaine-Related Disorders/therapy , Neuropsychology/methods , Conduct Disorder/complications , Diffusion Tensor Imaging , Adenoids/diagnostic imagingABSTRACT
Introducción: las enfermedades priónicas humanas constituyen una causa importante de demencia rápidamente progresiva e incurable, por lo que su diagnóstico diferencial con otras demencias tratables es fundamental. Actualmente se incluyen el EEG y la proteína 14-3-3 entre los criterios diagnósticos, pero estudios recientes destacan la sensibilidad y la especificidad de la RM cerebral. Nuestro objetivo es revisar una serie de pacientes con enfermedad de Creutzfeldt-Jakob esporádica (ECJe), analizando la importancia de la neuroimagen. Pacientes y métodos: estudio descriptivo y retrospectivo realizado en el Hospital General de Castellón en un período de 20 años (enero 1993-diciembre 2012), incluyendo pacientes con ECJe posible o probable. Resultados: 10 pacientes con ECJe (6 mujeres y 4 hombres), con una media de edad de 67 años (intervalo 54-82). El EEG fue útil en el 50 %, la proteína 14-3-3 positiva en el 100 % y la RM cerebral mostró alteraciones en la sustancia blanca cortical y en los ganglios basales en el 63%, cifra que aumentó hasta el 83% cuando se realizó secuencia DWI. Discusión: la RM cerebral en secuencia DWI y FLAIR es una técnica útil en el diagnóstico de la ECJ, superior al EEG, que permite detectar alteraciones incluso en estadios precoces de la enfermedad, por lo que creemos necesario incluirla entre los criterios diagnósticos (AU)
Introduction: human prion diseases are an important cause of rapidly progressive and incurable dementias, so its differential diagnosis from other treatable dementias is essential. Current criteria diagnosis includes EEG and 14-3-3 protein, however recent studies highlight the sensitivity and specificity of brain MRI. We aim to review a group of patients with sporadic Creutzfeldt-Jakob disease (sCJD), analyzing the importance of neuroimaging. Patients and methods: retrospective study performed in General Hospital of Castellón over a period of 20 years (January 1993 - December 2012), including patients with possible or probable sCJD. Results: 10 patients with sCJD (6 women, 4 men), mean age 67 years (54-82). The EEG was useful in 50%, 14-3-3 protein was positive in 100% and MRI showed abnormalities in cortical white matter and basal ganglia in 63%, increasing to 83% when performed DWI sequence. Discussion: DWI and FLAIR MRI is a useful technique in the diagnosis of CJD more than EEG, allowing us to detect abnormalities in early stages of the disease, thus it would be desirable considering the use of MRI in the diagnostic criteria (AU)
