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1.
Bull Cancer ; 104(12S): S71-S75, 2017 Dec.
Article in French | MEDLINE | ID: mdl-29126585

ABSTRACT

Providing information to living donors is first and foremost a legal obligation as well as an ethical one, not to mention necessary to health care provision. It's been shown that quality of information concerning the procedure's practical aspects, scheduling of clinical tests and examinations, withdrawing stem cells for the donation, post-donation symptoms, and support provided by healthcare teams, directly impacts the donor's quality of experience. Taking this into consideration our group decided it was essential to create an informational support for donors in the form of a booklet to be provided in different hematopoietic stem cell transplant centers across France. In September 2016 in Lille, France, the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 7th allergenic hematopoietic stem cell transplantation clinical practices harmonization workshops. As part of these workshops, our group worked collectively to develop a basis of indispensable information to be included in the booklet and presented using clear and accessible language.


Subject(s)
Hematopoietic Stem Cell Transplantation , Living Donors/education , Pamphlets , France , Hematopoietic Stem Cell Transplantation/adverse effects , Hematopoietic Stem Cell Transplantation/ethics , Hematopoietic Stem Cell Transplantation/legislation & jurisprudence , Humans , Societies, Medical
2.
Bull Cancer ; 103(11S): S229-S242, 2016 Nov.
Article in French | MEDLINE | ID: mdl-27842860

ABSTRACT

Haploidentical hematopoietic stem cell transplantation (HSCT) is being increasingly used due to improvement of the transplantation procedures allowing a reduction of graft-versus-host-disease (GVHD) and of transplant-related mortality (TRM). Such improvements have been particularly observed after administration of T-replete HSCT graft associated to an in vivo T cell depletion by the administration of high-doses of cyclophosphamide (HD-Cy) after transplantation. Here, we have analyzed the results of haplo-identical T replete HSC transplants, in particular, when performed with post-transplant HD-Cy in order to provide recommendations for the clinical practice. Criteria of choice for a haploidentical donor by priority order are absence of donor-specific antibodies (DSA) and to prioritize: CMV seronegative recipient/donor couples, ABO matching in case of deserythrocytation, male donor for a male recipient, the youngest donor. There is no clear argument in favor of the use of bone marrow versus peripheral blood stem cells (PBSC) after non myeloablative conditioning regimen, while after ablative conditioning PBSC seem to be associated with higher risks of GVHD without obvious impact on survival. Results of haploidentical HSCT, confirmed by several groups, are interesting in lymphomas (in particular Hodgkin disease) and for acute leukemia. Outcomes of patients rely on age, disease status at transplant and conditioning intensity. At equivalent disease risk, results of haploidentical HSCT seem comparable to those of HLA matched HSCT, raising the question of the classification of such transplants as alternatives. In all cases, we recommend to include patients in prospective clinical trials.


Subject(s)
Donor Selection/standards , Haploidy , Hematopoietic Stem Cell Transplantation , Histocompatibility/genetics , ABO Blood-Group System , Age Factors , Bone Marrow Transplantation/standards , Graft vs Host Disease/immunology , Graft vs Host Disease/prevention & control , Histocompatibility Testing , Hodgkin Disease/therapy , Humans , Leukemia/therapy , Lymphoma, Non-Hodgkin/therapy , Sex Factors , Societies, Medical , T-Lymphocytes/immunology , Transplantation Conditioning/methods
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