ABSTRACT
2,2'-Dipyridylamines (dpa) and related compounds belong to the family of polydentate nitrogen ligands. More than a century has passed since their first report but new complexes and applications have been emerging in recent years owing to the versatility of dpa-based architectures. This review aims to present and highlight the main achievements attained with dpa-containing metal complexes in the domains of homogeneous catalysis and luminescent materials.
ABSTRACT
Cyclometallated iridium(iii) dipyridylamine complexes present antibacterial activity against P. aeruginosa, a highly resistant pathogenic bacterium. This activity is increased when the complex is conjugated to biotin, a bacterial nutrient, and a MIC of 4 µM (4 µg mL-1) has been observed. The irradiation of P. aeruginosa cultures with blue LED light potentiates the anti-bacterial activities of these iridium(iii) complexes when they are conjugated to a glycoside.
Subject(s)
Anti-Bacterial Agents/pharmacology , Biotin/chemistry , Glycosides/chemistry , Iridium/pharmacology , Organometallic Compounds/pharmacology , Pseudomonas aeruginosa/drug effects , Anti-Bacterial Agents/chemistry , Iridium/chemistry , Light , Luminescence , Organometallic Compounds/chemistry , Pseudomonas aeruginosa/growth & development , Pseudomonas aeruginosa/radiation effectsABSTRACT
Starting from easily available chiral Schiff bases, a straightforward synthesis of air-stable titanium(IV) complexes was devised. Asymmetric pinacol coupling of aromatic aldehydes mediated and catalyzed by the corresponding low valent complexes afforded the chiral diols with high yields and enantioselectivities up to 91%. [reaction: see text]
