1.
Biomedicine
; 29(8): 276-9, 1978 Nov.
Article
in English
| MEDLINE
| ID: mdl-743562
ABSTRACT
Administration of a bromotriphenylethylene to C3H/f(XVII/G) female mice implanted with a pituitary under the kidney capsule produces with high doses (200 mg/kg or 20 mg/kg of diet) a strong inhibition of the development of the mammary glands. With a low dose (2 mg/kg) no inhibition was observed. In mice which received the high doses no hyperplastic alveolar nodules were observed. The activity of the compound is more pronounced after 50 days than after 25 days.
Subject(s)
Mammary Glands, Animal/drug effects , Stilbenes/pharmacology , Animals , Dose-Response Relationship, Drug , Female , Mammary Glands, Animal/growth & development , Mice , Mice, Inbred C3H , Pituitary Gland/physiology , Pituitary Gland/transplantation , Transplantation, Isogeneic
2.
C R Seances Soc Biol Fil
; 172(5): 845-9, 1978.
Article
in French
| MEDLINE
| ID: mdl-157196
ABSTRACT
Administration of bromotriphenylethylene to C3H/f female mice implanted with a pituitary under the kidney capsule produce an inhibition of mammary carcinogenesis with high doses (20 ppm or 200 ppm in the diet). With a diet containing 2 ppm no inhibition is observed.