ABSTRACT
La enfermedad de Castleman está considerada como un cuadro linfadenopático reactivo con dos formas clínicas: una localizada, frecuente en pacientes inmunocompetentes, y otra multicéntrica, más característica en los enfermos inmunodeprimidos. Se presentan dos casos de enfermedad de Castleman multicéntrica en pacientes VIH positivos con sarcoma de Kaposi. Ambos pacientes muestran adenopatías múltiples, hepatomegalia y síntomas B al diagnóstico. Uno de ellos presenta respuesta favorable al tratamiento quimioterápico y el otro fallece. Se realiza una revisión del concepto de enfermedad de Castleman multicéntrica, así como su relación patogénica con el virus herpes humano-8
Castleman disease is considered a reactive lymphadenopathic picture with two clinical forms: one localized, frequent in immunocompetent patients and another multicenter one that is more characteristic in immunodepressed patients. Two cases of Castleman disease multicenter in HIV positive patients with Kaposi's sarcoma are presented. Both patients have multiple adenopathies, hepatomegaly and symptoms B on diagnosis. One of them had a favorable response to chemotherapy treatment and another died. A review of the concept of multicenter Castleman disease and its pathogenic relationship to human herpes virus 8 (HHV-8) is done
Subject(s)
Adult , Middle Aged , Humans , Acquired Immunodeficiency Syndrome/complications , Castleman Disease/complications , Herpesvirus 8, Human , Sarcoma, Kaposi/complicationsABSTRACT
Castleman disease is considered a reactive lymphadenopathic picture with two clinical forms: one localized, frequent in immunocompetent patients and another multicenter one that is more characteristic in immunodepressed patients. Two cases of Castleman disease multicenter in HIV positive patients with Kaposi's sarcoma are presented. Both patients have multiple adenopathies, hepatomegaly and symptoms B on diagnosis. One of them had a favorable response to chemotherapy treatment and another died. A review of the concept of multicenter Castleman disease and its pathogenic relationship to human herpes virus 8 (HHV-8) is done.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Castleman Disease/complications , Herpesvirus 8, Human , Sarcoma, Kaposi/complications , Adult , Humans , Male , Middle AgedABSTRACT
Wegener's disease is characterized by necrotizing granulomatous vasculitis. The localized form involves the upper and lower respiratory tract, in the generalized form, the kidneys are also involved. In this paper, three cases of Wegener granulomatosis with otorhinolaryngological symptoms are reported. Frequently the presentation of this disease occurs in the ears, nose and throat, we think that the knowledge of this granulomatosis by the otorhinolaryngologist is necessary.
Subject(s)
Granulomatosis with Polyangiitis/complications , Otorhinolaryngologic Diseases/etiology , Adult , Female , Granulomatosis with Polyangiitis/diagnosis , Humans , Male , Middle AgedABSTRACT
A case of non-secreting bladder paraganglioma whose clinical manifestation was that of painless hematuria is described herein. Treatment was by partial cystectomy.
