Advances in solid-supported organic synthesis methods, 1998 to 1999.

Combinatorial chemistry is now regarded as an important component of the drug discovery process and is increasingly having an impact in other areas of the chemical sciences, such as catalysis and materials science. Solid-supported organic synthesis continues to be an integral component in the efficient assembly of combinatorial libraries. This review attempts to describe some of the most important recent developments in solid-supported organic synthesis during the period 1998 to 1999. Particular emphasis is placed on the development of novel, efficient methods for the synthesis of diverse, non-oligomeric libraries and structurally complex molecules.