1.
Bioorg Med Chem Lett
; 13(17): 2895-8, 2003 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-14611852
ABSTRACT
A novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective inhibitory properties against a panel of protein tyrosine phosphatases including PTP1B. Compounds 12 and 13 display oral glucose lowering effects in ob/ob mice.