Porous Functionalized Covalent-Triazine Frameworks for Enhanced Adsorption Toward Polysulfides in Li-S Batteries and Organic Dyes.

The incorporation of functional building blocks to construct functionalized and highly porous covalent triazine frameworks (CTFs) is essential to the emerging adsorptive-involved field. Herein, a series of amide functionalized CTFs (CTF-PO71) have been synthesized using a bottom-up strategy in which pigment PO71 with an amide group is employed as a monomer under ionothermal conditions with ZnCl2 as the solvent and catalyst. The pore structure can be controlled by the amount of ZnCl2 to monomer ratio. Benefitting from the highly porous structure and amide functionalities, CTF-PO71, as a sulfur cathode host, simultaneously demonstrates physical confinement and chemical anchoring of sulfur species, thus leading to superior capacity, cycling stability, and rate capability in comparison to unfunctionalized CTF. Meanwhile, as an adsorbent of organic dye molecules, CTF-PO71 was demonstrated to exhibit strong chemical interactions with dye molecules, facilitating adsorption kinetics and thereby promoting the adsorption rate and capacity. Furthermore, the dynamic adsorption experiments of organic dyes from solutions showed selectivity/priority of CTF-PO71s for specific dye molecules.

Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model.

The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes - probably amylase or its peptides - on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes.

Synthesis and crystal structure of N-(4-chloro-phen-yl)-5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-amine.

The title compound, C13H12ClN5, was synthesized by the cyclization of 1-(4,6-di-methyl-pyrimidin-2-yl)-4-phenyl-thio-semicarbazide in the presence of Ni(NO3)2. The mol-ecular structure of the compound is essentially planar. In the crystal, mol-ecules form dimers via pairs of N-H⋯N hydrogen bonds between the H atom of the exocyclic amino group and the N atom at the 4-position of the triazole ring. The resulting dimers are packed into layers which are connected by π-stacking inter-actions between the aromatic systems of the pyrimidine and benzene nuclei, and between the triazole cores.