[Hormonal, radiation and combined therapy of locally advanced prostatic cancer (T3NXM0)].

The analysis is presented of combined treatment of locally advanced prostatic cancer (LAPC), stage T3NXM0, in 158 LAPC patients treated in 1998-2002. The patients were divided into four groups: group 1 (n=72) received hormones in parallel with radiation, group 2 (n=52) received only hormones, group 3 (n=27) received radiotherapy after failure of long-term (1 year and more) hormone therapy, group 4 (n=7) was given teleradiotherapy only. 3-year recurrence-free survival in patients with LAPC showed advantage of the combined treatment (82 +/- 0.1%) vs hormone (56 +/- 0.1%) or radiation (69.3 +/- 0.1%) therapy alone. It provides a high local control over the primary tumor and an increase of survival, prolongs distant metastases free period, improves the patients' quality of life and their adaptation.

[The proliferative activity of stomach cancer and evaluation of its individual radiosensitivity]. / Proliferativnaia aktivnost' raka zheludka i otsenka individual'noi radiochuvstvitel'nosti.

An indirect immunofluorescent method with polyclonal antibodies to thymidine was used to assess the proliferative activity (PA--percent of cells in the S-phase of the cell cycle) of 79 stomach tumors from primary cancer patients. Stomach cancer PA was shown to vary from 0.1 to 69.7%. PA did not depend either on a tumor size or a degree of the involvement of regional lymph nodes. The mean PA of well-differentiated adenocarcinoma was slightly lower (14.9 +/- 4.7%) than that of low differentiated ones. Of 79 patients a tumor process was interpreted as a resectable one in 62. They were given preoperative irradiation at a total focal dose of 36 Gy followed by operation. In addition to initial investigation PA in tumor biopsy specimens was assessed after delivering a dose of 12 Gy. PA changes at the beginning of a course of irradiation were compared with a degree of a radiation injury of tumor tissue after a course of irradiation was discontinued in 32 (explorative laparotomy was performed in 30). It was shown that tumor radioresistance could be predicted in unchanged PA indices of their increase at the beginning of a course of irradiation with the probability of 95%.

[Approaches to predicting the reaction of human tumors to radiotherapy]. / Podkhody k prognozirovaniiu reaktsii opukholei cheloveka na luchevuiu terapiiu.

Immunofluorescent method using anti-thymidine antibodies was employed to assess proliferative activity of 217 human tumors including oropharyngeal, esophageal, gastric, rectal and lung cancer. The activity was evaluated before and, in 38 neoplasms, in the course of radiotherapy. It was shown that changes in the proliferative activity of oropharyngeal and gastric malignancies observed early in the course of radiation treatment may serve for predicting response.