1.
Biochim Biophys Acta
; 1444(2): 299-305, 1999 Feb 16.
Article
in English
| MEDLINE
| ID: mdl-10023088
ABSTRACT
Ataxin-3 is a protein of unknown function which is mutated in Machado-Joseph disease by expansion of a genetically unstable CAG repeat encoding polyglutamine. By analysis of chicken ataxin-3 we were able to identify four conserved domains of the protein and detected widespread expression in chicken tissues. In the first such analysis in a non-primate species we found that in contrast to primates, the chicken CAG repeat is short and genetically stable.