ABSTRACT
Three fibrous histiocytomas, primary in skin, were studied by light and electron microscopy and by frozen section histochemistry. The term malignant was applied to cutaneous tumors which demonstrated aggressive multinodular local growth, including angioinvasion and/or extension into bone, muscle, and fascia. Metastases were not found. Strongly positive reactions for hydrolytic enzymes, particularly acid phosphatase will help differentiate malignant fibrous histiocytoma from most other primary soft tissue malignancies of skin. Electron microscopic studies reaffirm the presence of both histiocyte-like and fibroblast-like cells. Langerhans' granules were not identified. Primary malignant fibrous histiocytoma of skin may have a prognosis superior to homologous tumors arising in deeper soft tissue and the retroperitoneum.
Subject(s)
Histiocytoma, Benign Fibrous/pathology , Skin Neoplasms/pathology , Skin/pathology , Adult , Female , Histiocytoma, Benign Fibrous/ultrastructure , Humans , Male , Middle Aged , Skin/ultrastructure , Skin Neoplasms/ultrastructureABSTRACT
Acinic-cell carcinomas and mucoepidermoid carcinomas remain somewhat controversial salivary-gland lesions. Because of an ambiguity in the literature concerning their malignant potential and a lack of sufficient follow-up periods, these carcinomas have been underestimated with respect to their morbidity and lethality. The failure of histopathologic evaluation to successfully predict the subsequent biologic course of these neoplasms should not mitigate treatment. Acinic-cell carcinomas are usually isomorphic neoplasms having their genesis in the neoplastic reserve cells of the terminal portions of the duct system. Mucoepidermoid carcinomas, on the other hand, may be described as forming a histologic spectrum or continuum from the most highly differentiated to the most poorly differentiated malignancy. They arise from the interlobular and intralobular ducts. The histopathologic features of these two neoplasms are presented, along with a review of their biologic activity in humans.
Subject(s)
Carcinoma/pathology , Salivary Gland Neoplasms/pathology , Adolescent , Adult , Aged , Carcinoma/classification , Carcinoma/diagnosis , Cell Transformation, Neoplastic , Child , Child, Preschool , Female , Humans , Infant , Jaw Neoplasms/pathology , Male , Middle Aged , Mucus , Parotid Neoplasms/pathology , Prognosis , Salivary Gland Neoplasms/classification , Salivary Gland Neoplasms/diagnosis , Salivary Glands, Minor/pathology , Submandibular Gland/pathologyABSTRACT
In a double-blind retrospective analysis, sections of lymph nodes removed at the time of laryngectomy and homolateral neck dissection were microscopically examined to assess the histopathological manifestations of an immune response. Contrary to an earlier study, no strong correlation appears to exist between the host response as manifested by the lymphnode morphology and survival or metastases. The question of preoperative irradiation altering the lymph node's ability to respond effectively is raised and puts in jeopardy such a morphological assessment in patients who have received preoperative radiotherapy.
