ABSTRACT
Introducción: Las metástasis de tumores sólidos al tiroides son infrecuentes y las metástasis a un tumor tiroideo preexistente aún más raras. Pacientes y métodos: Presentamos el caso de una mujer de 30 años con metástasis de carcinoma de mama sobre un carcinoma folicular de tiroides. Resultados: El proceso metastásico fue diagnosticado como un hallazgo tras la realización de tiroidectomía por diagnóstico clínico de bocio nodular coloide. El estudio histológico mostró focos de carcinoma de mama sobre una proliferación tumoral de folículos tiroideos con invasión de la cápsula (AU)
Introduction: Metastases from solid tumors to thyroid gland are very uncommon findings and metastases to a pre- existing thyroid neoplasm are even more infrequent. Patients and methods: A case of a breast carcinoma metastasizing to a follicular carcinoma of the thyroid gland in a 30-year-old woman is reported. Results: Intratumoral metastasis was diagnosed as an incidental finding in a thyroidectomy specimen clinically diagnosed as nodular colloid goiter. Histological study showed breast carcinoma nests dispersed within a thyroid tumor showing follicular cell differentiation and capsular invasion (AU)
Subject(s)
Adult , Female , Humans , Carcinoma, Ductal, Breast/diagnosis , Carcinoma, Ductal, Breast/pathology , Neoplasm Metastasis/pathology , Thyroglobulin , Breast Neoplasms/diagnosis , Breast Neoplasms/complications , Carcinoma, Papillary, Follicular , Adenocarcinoma, Follicular , Thyroid Gland , ImmunohistochemistryABSTRACT
The present study has been performed to investigate the effect of i.v. administration of taurine on the electrical activity of the epileptogenic focus induced by penicillin applied to the right sensory motor cortex of adult rats. Taurine (100 mg/kg body weight) was administered 15, 30, 60, and 120 min before the application of penicillin. The EEG was unipolarly recorded by means of electrodes applied to the pia. Taurine caused a decrease of the frequency as well as the spike amplitude of epileptic discharge. The spread of epileptogenic foci to the opposite hemisphere was retarded when compared to that of control animals. The maximal antiepileptic effect of taurine was observed when the amino acid was administered 30-60 min previous to penicillin. It is suggested that high concentrations of taurine in the brain might be necessary to inhibit the epileptic activity.
