ABSTRACT
The synthesis of the title compound (X) is easily achieved by suitable transformations of the lateral chains of the 1-ethylenedioxy-2-allyl--trans-3-cyclopentane acetic acid (II).
Subject(s)
Fatty Acids/chemical synthesis , Prostanoic Acids/chemical synthesis , Animals , Chemical Phenomena , Chemistry , Gastric Mucosa/drug effects , Gastric Mucosa/metabolism , Guinea Pigs , Methods , Prostanoic Acids/pharmacologySubject(s)
Cyclopentanes , Acetylene , Alkenes , Chemical Phenomena , Chemistry , Oxidation-Reduction , Spectrophotometry, Infrared/methodsABSTRACT
An efficient synthesis of n.hexanoylmethylenetriphenylphosphorane (II), a fundamental intermediate for obtaining prostanoic products, is described. The crucial intermediate in the synthesis is the 2-keto-n.heptyltriphenylphosphonium chloride (VII), which is prepared via a very precise procedure.
Subject(s)
Phosphoranes/chemical synthesis , Chemical Phenomena , Chemistry , Methods , Prostanoic Acids/chemical synthesisABSTRACT
The employment of malonic acid dimethylester as a blocking group of a dynamic and self isomerising alpha,beta-unsaturated cyclopentanone-exomethylene group is reported.
Subject(s)
Cyclopentanes , Chemical Phenomena , Chemistry , Decarboxylation , Desiccation , Hydrolysis , TemperatureABSTRACT
An efficient synthesis of n.pentanoylmethylenetriphenylphosphorane (II), useful intermediate for achievement of prostanoic derivatives, is described. The procedure affords the desired product at a remarkable degree of purity.
Subject(s)
Phosphoranes/chemical synthesis , Chemical Phenomena , Chemistry , Prostanoic AcidsABSTRACT
The synthesis of (+/-)-1-ethylenedioxy-trans-2-(beta-R,S-hydroxypropyl)-3-(beta-acetoxyethyl)cyclopentane (IV), starting from (+/-)-1-ethylenedioxy-trans-2-propargyl-3-(beta-hydroxyethyl)cyclopentane (I) by indirect hydration with mercuric acetate and hydrogen sulphide, is reported.
