A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population that underwent bariatric surgery.

OBJECTIVES: The rs9939609 single nucleotide polymorphism (SNP) in the fat mass and obesity-associated (FTO) gene is involved in obesity. Few studies have been conducted on patients who underwent bariatric surgery. The aim of this study was to evaluate the influence of FTO SNPs on body weight, body composition, and weight regain during a 60-mo follow-up period after bariatric surgery. METHODS: The rs9939609 was genotyped in 146 individuals using a real-time polymerase chain reaction TaqMan assay. Data for lifestyle, comorbidities, body weight, body mass index (BMI), excess weight loss (EWL), and body composition were obtained before and 6, 12, 18, 24, 36, 48, and 60 mo after surgery. Data were analyzed by comparing two groups of patients according to rs9939609 FTO gene polymorphism. Mixed-regression models were constructed to evaluate the dynamics of body weight, BMI, and EWL over time in female patients. RESULTS: No differences were observed between the groups during the first 24 mo after surgery. After 36, 48, and 60 mo, body weight, fat mass, and BMI were higher, whereas fat-free mass and EWL were lower in the FTO-SNP patient group. Weight regain was more frequent and occurred sooner in the FTO-SNP group. CONCLUSIONS: There is a different evolution of weight loss in obese carriers of the FTO gene variant rs9939609 after bariatric surgery. However, this pattern was evident at only 2 y postbariatric surgery, inducing a lower proportion of surgery success and a greater and earlier weight regain.

Valores de referência de ingestão de nutrientes para avaliação e planejamento de dietas de crianças de um a oito anos / Dietary reference intakes for the evaluation and planning of diets for children aged one to eight years

Os valores de referência de ingestão dietética (Dietary Reference Intakes - DRIs) foram desenvolvidos para auxiliar no planejamento alimentar e avaliação da ingestão de nutrientes de indivíduos e populações. Foram propostos a partir do final da década de 90, em substituição às recomendações estabelecidas em 1989 (RDAs), visando a implementação de inovações como a criação de novos conceitos de avaliação e planejamento de dietas, devido à disponibilidade de informações atualizadas sobre necessidades e ingestão de nutrientes; o estabelecimento dos níveis máximos de ingestão com o surgimento do conceito de redução do risco de doenças crônico-degenerativas e a subdivisão dentro de cada faixa etária, devido às demandas diferenciadas de nutrientes para cada etapa da vida. Considerando a importância da avaliaçãodo consumo alimentar na atenção integral à saúde da criança e a fim de subsidiar os profissionais de saúde no diagnóstico e acompanhamento nutricional, o objetivo deste trabalho foi apresentar de maneira prática as recomendações nutricionais e seu modo de aplicação em crianças de um a oito anos de idade baseando-se na metodologia das DRIs.

Dietary Reference Intakes (DRIs) have been developed in order to help dietary planning and the assessment of nutrient intake for individuals and populations. These values were proposed in the late nineties to replace the recommended daily allowances (RDAs), innovating and creating new concepts of dietary planning and assessment due to the recently updated information about nutrient requirements, the establishment of maximum intake levels in need to include the concept of risk-reduction of chronic-degenerative diseases, and a subdivision within each age range due to the different nutrient requirements in each stage of life. Considering the food consumption assessment important in full-range attention to the children’s health, and enabling funds to health professionals in nutritional monitoring and diagnosis, the main objective of the current study was to present, in a practice way, the nutritional recommendations and their applications for children aged 1 to 8 years old, based on the DRIs Methodology.

Avaliação da prescrição dietética de crianças hospitalizadas / Assessment of dietetic order in hospitalize infants

Modelo do estudo: Estudo de prevalência. Objetivo: A subnutrição é freqüentemente observada em crianças hospitalizadas e está associada a um pior prognóstico. A correta abordagem nutricional, incluindo a prescrição dietética, melhora a evolução clínica. O objetivo desse estudo foi avaliar a adequação da prescrição dietética em crianças hospitalizadas. Métodos: Vinte e uma crianças foram acompanhadas de Julho a Setembro de 2004. Foi realizado a avaliação das prescrições dietéticas de crianças recebendo nutrição enteral durante três períodos da internação. Resultados: Houve inadequação do peso durante a hospitalização (dia 1 =76.4 ± 18.2%; dia 2 = 76.1 ± 18.6%; dia 3 = 76.7 ± 19.6%), sem alteração durante o período do estudo. A prescrição energética foi inadequada, porém as de proteínas e micronutrientes apresentaram-se dentro da recomendação. Conclusão: A condição clínica pode afetar de maneira negativa a prescrição nutricional. A equipe multidisciplinar deve se empenhar ao máximo para atingir as necessidades energéticas das crianças hospitalizadas.

Background: Malnutrition is frequently found in hospitalized children and is associated with poor outcome. The adequate nutritional approach improves clinical evaluation.The aim of this study was to evaluate the adequacy of dietetic enteral order in hospitalized children. Methods: Twenty one children were followed from july to september 2004. The dietetic enteral orders were registered during three periods of hospitalization. Results: The children body weight was inadequate and didn´t changed during the hospitalization (day 1 = 76.4 ± 18.2%; day 2 = 76.1± 18.6%; day 3 = 76.7 ± 19.6%). Energy dietetic order was inadequate but protein and micronutrients were according to the recommendation. Conclusion: Clinical condition may negativelly affect the nutritional order. The multidisciplinary team should give all the efforts to meet the appropriate dietetic energy order of hospitalized children.