Subject(s)
Cardiovascular Diseases/diagnostic imaging , Cardiovascular Diseases/epidemiology , Intra-Abdominal Fat/diagnostic imaging , Adult , Aged , Brazil/epidemiology , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Prospective Studies , Risk Factors , Ultrasonography , Young AdultABSTRACT
This study evaluated the effects of 2 different types of acute aerobic exercise on the osmotic stability of human erythrocyte membrane and on different hematological and biochemical variables that are associated with this membrane property. The study population consisted of 20 healthy and active men. Participants performed single sessions of 2 types of exercise. The first session consisted of 60 min of moderate-intensity continuous exercise (MICE). The second session, executed a week later, consisted of high-intensity interval exercise (HIIE) until exhaustion. The osmotic stability of the erythrocyte membrane was represented by the inverse of the salt concentration (1/H50) at the midpoint of the sigmoidal curve of dependence between the absorbance of hemoglobin and the NaCl concentration. The values of 1/H50 changed from 2.29±0.1 to 2.33±0.09 after MICE and from 2.30±0.08 to 2.23±0.12 after HIIE. During MICE mean corpuscular volume increased, probably due to in vivo lysis of older erythrocytes, with preservation of cells that were larger and more resistant to in vitro lysis. The study showed that a single bout of acute exercise affected erythrocyte stability, which increased after MICE and decreased after HIIE.
Subject(s)
Erythrocyte Membrane/physiology , Exercise/physiology , Adult , Glutathione Peroxidase/blood , Hematologic Tests , Humans , Male , Osmotic Fragility , Young AdultABSTRACT
Auto medicaçäo com plantas pode levar a envenenamentos graves. A espirradeira (nerium oleander) é uma planta ornamental cuja toxicidade para o homem é atribuída a uma mistura de glicosídeos cardíacos näo digitálicos. As manifestaç 8es clínicas do envenenamento pela espirradeira combinam sintomas cardíacos e gastrointestinais, e säo semelhantes aos da intoxicaçäo digitálica. RELATO DE CASO - Após ter ingerido um chá feito de folhas de espirradeira, uma mulher de 33 anos apresentou tonturas, vômitos e cólicas abdominais como sintomas principais, e bloqueio atrioventricular total, que reverteu espontaneamente em 24 horas. Ela permaneceu com bradicardia, tonturas e diarréia por cerca de 6 dias. Na admissäo apresentava potássio sérico de 6,7 mEq/L e creatinina sérica de 2,3 mg por cento, níveis que, progressivamente, retornaram ao normal. CONCLUSAO - Envenenamento por Nerium oleander deve ser incluído no diagnóstico diferencial das bradiarritmias, particularmente em crianças e jovens sem cardiopatia conhecida, nas áreas onde esta planta seja usada como erva medicinal, ou onde suas propriedades tóxicas seja conhecidas
Subject(s)
Humans , Female , Adult , Heart Block/etiology , Plant Poisoning , Bradycardia/etiology , Digitalis Glycosides/poisoning , Potassium/bloodABSTRACT
BACKGROUND: Self-medication with plants can lead to severe poisoning. Oleander (Nerium oleander) is an ornamental plant whose toxicity to man is due to a mixture of nondigitalis cardiac glycosides. The clinical manifestations of oleander poisoning combine cardiac and gastrointestinal symptoms, and are similar to those of a digitalis overdose. CASE REPORT: Following the ingestion of tea made of the leaves of oleander, a 33-year-old woman developed dizziness, vomiting and abdominal cramps as main symptoms, and complete atrioventricular block that reverted within 24 hours. She remained with bradycardia, dizziness and diarrhea for about 6 days. On admission she had a serum potassium of 6.7 mEq/L and a serum creatinine of 2.3 mg%, that progressively returned to normal levels. CONCLUSION: Clinicians must include oleander poisoning in the differential diagnosis of bradyarrhythmias, particularly in children and young people without known cardiovascular disease, in areas where this plant either is used as a herbal medicine or is known as poisonous.
Subject(s)
Heart Block/etiology , Plant Poisoning , Plants, Toxic , Adult , Bradycardia/etiology , Digitalis Glycosides/poisoning , Female , Humans , Potassium/bloodABSTRACT
A taquicardia atrial induzida artificialmente em cäo produziu nas nossas condiçöes, alteraçäo importante da funçäo renal. Essa alteraçäo se manifestou por significativo aumento do volume urinário por minuto (1,3 ñ 0,12 no controle para 3,2 ñ 0,6ml/min no experimental) e da fraçäo de excreçäo de sódio (FENa) (de 2,3 ñ 0,3 no controle para 3,6 ñ 0,5), na presença de queda significante do fluxo sanguíneo renal (317 ñ 30,9 para 232 ñ 26,7 ml/min), sem alterar o ritmo de filtraçäo glomerular (66,1 ñ 6,7 no controle para 70,6 ñ 6,5 ml/min no experimental). Quanto à hemodinâmica sistêmica, observamos queda signficante do débito cardíaco e aumentos significantes da resistência vascular sistêmica e da pressäo de capilar pulmonar. Esses resultados demonstram que possivelmente fatores näo relacionados à hemodinâmica sistêmica, mas relacionados a alteraçöes hormonais, sejam responsáveis por estas alteraçöes
