Ancient Observation of Spinal Cord Injury: The Case of the Assyrian Lion.

The description of paraplegia is considered a milestone in the history of neurology. The Egyptians provided excellent descriptions of spinal cord injuries, the Bible has several references to paraplegia, and, more recently, the pioneers of neurology described the classic syndromes related to spinal injuries and paraplegia. Here, we describe an ancient observation by the Assyrian people of paraplegia in an animal. In ancient Assyria, lion hunting was a ritualized activity conducted for political and religious purposes. The Lion Hunt of Ashurbanipal, a series of Assyrian palace reliefs from the North Palace at Nineveh dating from approximately 645 BCE, which is now in the British Museum in London, UK, shows King Ashurbanipal hunting lions. Applying modern knowledge of mammalian dermatomes to the images, we reveal a detailed and precise observation of paraplegia after spinal cord injury.

Análise do líquido cefalorraquidiano de bugio-ruivo (Alouatta guariba) / Cerebrospinal fluid analysis of the howler monkey (Alouatta guariba)

A presente pesquisa foi realizada com o objetivo de desenvolver e adaptar técnicas diagnósticas em neurologia para primatas não humanos, da espécie Alouatta guariba Geoffroy Saint-Hilaire, 1812 (bugio-ruivo) saudáveis e mantidos em cativeiro. Foram realizadas análises físico-químicas e citológicas do líquido cefalorraquidiano obtido na cisterna magna de oito bugios-ruivos. Para realização dos exames, todos os animais foram contidos quimicamente com associação de cetamina, xilazina e midazolam e anestesia inalatória com isoflurano. Os resultados das análises do líquido cefalorraquidiano demonstraram valores médios de proteína: 16,92mg/dL±9,84; glicose: 131,25mg/dL±106,7; pH: 8,37±0,69; células nucleadas: 0,5/mm³±0,75; hemácias: 49,37/mm³±111,76 e pressão: 7,37cm H2O±1,77. O trabalho demonstrou a segurança e a eficácia da colheita do líquido cefalorraquidiano na cisterna magna de Alouatta guariba e os valores de referência para a espécie.

This survey was conducted with the objective of developing and adapting diagnostic techniques in neurology for non-human primates, of the species Alouatta guariba Geoffroy Saint-Hilaire, 1812 (howler monkey) healthy and kept in captivity. Physical-chemical analyses were carried out in cerebrospinal fluid and its pressure measurement in the cisterna magna. Eight animals were used for the analysis of cerebrospinal fluid. In all procedures, were used chemical restraint and anesthesia with ketamine, xylazine and association of midazolam and inhalational anesthesia with isoflurane for carrying out the spinal tap. The cerebrospinal fluid analysis showed average values: protein: 16.92±9.84; glucose: 131.25mg/dL±106.7; pH: 8.37±0.69; nucleated cells: 0.5/mm³±0.75; red blood cells: 49.37/mm³±111.76 and CSF cisternal pressure: 7.37cm H2O±1.77. This study demonstrated the safety and efficacy of cerebrospinal fluid collection in the cisterna magna of Alouatta guariba, and the reference values for the specie.

A form of dysplasia or a fortuitous association? A cerebral aneurysm inside an arachnoid cyst: case report.

OBJECTIVE: Although arachnoid cysts and intracranial aneurysms are very common lesions, their association in the same patient is rare. We present a case of a middle cerebral artery aneurysm ruptured into an arachnoid cyst. We found only six cases with intracystic hemorrhage reported in the literature. The presence of an arachnoid cyst can mislead clinical presentation. The patient presented a paradoxically small temporal fossa and thickening of the temporal and sphenoid bone. The authors suggest that this uncommon association (arachnoid cyst, atypical cranial vault, and "mirror-like" cerebral aneurysm) could represent a form of dysplasia. CLINICAL PRESENTATION: A 46-year-old patient presented with a 3-week history of slight headaches, which had worsened in the last 3 days before presentation. Computed tomographic scans showed a cystic lesion located in the middle cranial fossa and sylvian fissure with suspected aneurysm dilation inside. Magnetic resonance imaging scans showed an intracystic hemorrhage but not subarachnoid hemorrhage. Paradoxically, changes in the cranial vault around the cyst were noted. Digital subtraction angiography showed bilateral "mirror" middle cerebral artery aneurysms. INTERVENTION: A large right pterional craniotomy was performed with full microsurgical removal of the arachnoid cyst walls and aneurysm clipping. The aneurysm was in the medial wall of the arachnoid cyst with its dome inside the cyst. The contralateral aneurysm was clipped 2 weeks later. The follow-up period was uneventful, and the patient returned to normal life. CONCLUSION: Rupture of a cerebral aneurysm into an arachnoid cyst is rare. Clinical presentation may be unusual because the cyst can prevent subarachnoid hemorrhage. A middle fossa cranial arachnoid cyst in the presence of temporal bone depression, small middle fossa, and thickness of squamous temporal bone and the lesser wing of sphenoid is rare and suggests that congenital factors may play an important role in their development. The exceptional association between "mirror" aneurysms and arachnoid cyst with bone changes suggests a possible congenital form of dysplasia.

Laryngeal electromyography in movement disorders: preliminary data

Este estudo descreve dados preliminares de eletromiografia laríngea (LEMG) e tratamento com toxina botulínica em pacientes com disfonia associada a distúrbios do movimento. Foram estudados 25 pacientes, 19 com distonia laríngea ou disfonia espasmódica, 5 com tremor vocal e 1 com síndrome de Gilles de la Tourette. LEMG realizada com eletrodos monopolares, antes da administração de toxina botulínica, foi compatível com distonia em 14 pacientes (normal em 5), sugeriu tremor essencial em 3 e Parkinson em 2. Os diferentes padrões de LEMG e melhora considerável obtida com administração de toxina botulínica instituíram LEMG como rotina no ambulatório de distúrbios do movimento da UNICAMP.

Laryngeal electromyography in movement disorders: preliminary data.

This study describes preliminary laryngeal electromyography (LEMG) data and botulinum toxin treatment in patients with dysphonia due to movement disorders. Twenty-five patients who had been clinically selected for botulinum toxin administration were examined, 19 with suspected laryngeal dystonia or spasmodic dysphonia (SD), 5 with vocal tremor, and 1 with Gilles de la Tourette syndrome (GTS). LEMG evaluations were performed before botulinum toxin administration using monopolar electrodes. Electromyography was consistent with dystonia in 14 patients and normal in 5, and differences in frequency suggesting essential tremor in 3 and Parkinson tremors in 2. The different LEMG patterns and significant improvement in our patients from botulinum toxin therapy has led us to perform laryngeal electromyography as a routine in UNICAMP movement disorders ambulatory.

Manifestaçöes reumáticas e neoplasias / Rheumatic manifestations and neoplasms

Os autores fazem um estudo retrospectivo de 21 pacientes com diagnóstico de tumores benignos e malignos realizados no Serviço de Reumatologia da Faculdade de Medicina do Triângulo Mineiro e com pacientes de suas próprias clínicas. Descrevem uma manifestaçäo reumática oriunda de tumores malignos e benignos e a relaçäo temporal existente entre eles, bem como o sintoma osteoarticular. Enfatizam a necessidade de um exame físico cuidadoso e um histórico detalhado por mais insignificantes que as queixas possam parecer. Os autores discutem, ainda, o diagnóstico diferencial com outras entidades reumáticas