[Chromatin nuclear proteins in evaluation of the effectiveness of treatment of patients with psoriasis]. / Iadernye belki khromatina v otsenke éffektivnosti lecheniia bol'nykh psoriazom.

Histone proteins and nucleic acid precursors were studied in 10 normal subjects and 20 patients with disseminated psoriasis before and after combined therapy including Enkad. A drop in the concentrations of H1 histones was detected in the blood lymphocytes and plasma in parallel with an increase in the concentrations of arginine-rich histones and a many-fold decrease in the acid-soluble fraction representing a pool of nucleic acid precursors. After combined therapy the ratio of lysin- and arginine-rich nuclear proteins in blood lymphocytes changed significantly and approximated the normal value; the distribution of histone-like proteins virtually did not change in the plasma, but the level of plasma and erythrocyte acid-soluble fraction normalized. This indicates positive changes in nucleic acid transport after therapy. The authors demonstrate the possibility of these findings for evaluation of the treatment efficiency.

[Lupus erythematosus: effects of different therapeutic methods on intranuclear characteristics of lymphoid cells]. / Vliianie razlichnykh metodov lecheniia krasnoi volchanki na vnutriiadernye kharakteristiki limfoidnykh kletok.

In lymphocytes of peripheral blood from 46 patients with various forms of lupus erythematosus measurements were made of histone fractions and DNA. It is proved that intranuclear characteristics of lymphoid cells can be used in the choice of treatment and assessment of its efficacy. Lupus erythematosus treatment with glucocorticoids (diprospan, diprospan + celeston) is effective in correction of intranuclear lymphocyte changes in this disease.

[An analysis of the lymphoid cell histones in patients with different forms of lupus erythematosus]. / Analiz gistonov limfoidnykh kletok u bol'nykh s razlichnymi formami krasnoi volchanki.

The study was made of lisine- and arginine-rich histone fractions and DNA in lymphocytes of peripheral blood in patients with lupus erythematosus. The findings showed intranuclear changes of immunocompetent cells in various forms of the disease. The above parameters may be used in the diagnosis, evaluation of treatment efficacy, prognosis.

[Metabolism of nuclear proteins of the thymus and bone marrow cells in mice with hepatoma 22]. / Metabolizm iadernykh belkov v kletkakh timusa i kostnogo mozga myshei s gepatomoi 22.

Specific characteristics of nuclear proteins synthesis were studied in thymus and bone marrow cells of mice with solid hepatoma 22, which enabled to find three main periods of alterations in the protein synthesis within 1-3 days, 5-9 and 11-13 days after administration of hepatoma 22. The most distinct alterations were observed within first day after the hepatoma 22 administration, which may be considered as a primary reaction of nuclear apparatus in the cells of tumor-bearing animals.

[Effect of hormones and partial hepatectomy on incorporation of labeled precursor in nuclear proteins of mouse liver]. / Vliianie gormonov i operatsii chastichnoi gepatéktomii na vkliuchenie mechenogo predshestvennika v iadernye belki pecheni myshei.

Partial hepatectomy altered the nuclear protein synthesis, most distinct for H1 histones, within 1,5-3 hrs after the operation. Laparotomy, administration of hormones and dibutyryl-cAMP did not affect the cell nuclear apparatus throughout similar to partial hepatectomy. The cell response to partial hepatectomy appears to develop involving a number of factors between which unspecific stress reactions and hormones carry out a definite role.

[Effect of a single dose of hydrocortisone and adrenaline on the synthesis of nuclear proteins and DNA in the rat thymus]. / Vliianie odnokratnogo vvedeniia gidrokortizona i adrenalina na uroven' sinteza iadernykh belkov i DNK v timuse krys.

Single injections of hydrocortisone and adrenaline low doses long before the rat killing induced a change in the level of thymic DNA and nuclear protein synthesis. The effect and direction of hormone activity were dependent on the day time and duration of hormone presence in the organism. Hydrocortisone in a dose of 10 mg/kg, injected at 11 o'clock, promoted thymic DNA synthesis, whereas adrenaline in a dose of 0.06 mg/kg, administered at 11 o'clock, inhibited DNA synthesis, stimulating it, when injected at 23 o'clock.