1.
J Lab Clin Med
; 89(2): 414-20, 1977 Feb.
Article
in English
| MEDLINE
| ID: mdl-833477
ABSTRACT
The published values for serum protein binding of antibiotics vary considerably depending upon the method and experimental conditions used. A rapid, simple, and standardized ultrafiltration procedure for determination of the serum protein binding of antibiotics has been developed and used to compare the binding characteristics of four marketed cephalosporins. The human serum protein binding of cephradine, cephalexin, cephalothin, and cefazolin at 37 degrees C. and physiological pH (7.4) was found to be 13.8, 12.4, 71.2, and 89.2 per cent, respectively. These values fall within the range of published values for these antibiotics.
Subject(s)
Blood Proteins/metabolism , Cephalosporins/metabolism , Cefazolin/metabolism , Cephalexin/metabolism , Cephalothin/metabolism , Cephradine/metabolism , Humans , Protein Binding , Ultrafiltration/methods
2.
Pa Med
; 77(9): 51-3, 1974 Sep.
Article
in English
| MEDLINE
| ID: mdl-4424916
Subject(s)
Electrocardiography , Hypoxia/physiopathology , Adolescent , Aged , Female , Foreign Bodies , Humans , Hypoxia/chemically induced , Hypoxia/etiology , Male , Meprobamate/adverse effects , Morphine/poisoning , Trachea
3.
Neurology
; 19(11): 1125-30, 1969 Nov.
Article
in English
| MEDLINE
| ID: mdl-5388082
4.
Am J Proctol
; 18(1): 55-8, 1967 Feb.
Article
in English
| MEDLINE
| ID: mdl-5298662
5.
Med Times
; 94(8): 895-6, 1966 Aug.
Article
in English
| MEDLINE
| ID: mdl-5938842
6.
Pa Med
; 69(1): 48-9, 1966 Jan.
Article
in English
| MEDLINE
| ID: mdl-5321620