ABSTRACT
To determine if tissue plasminogen activator, a clot-specific fibrinolytic agent, could eventually be used to assist in the clearance or removal of subretinal hemorrhage, we studied the effect of subretinal injections of tissue plasminogen activator, autologous blood, balanced salt solution, and the combination of either tissue plasminogen activator or balanced salt solution after subretinal injection of autologous blood on retinal morphologic characteristics and clearance of subretinal hemorrhage in the albino rabbit. No morphologic evidence of tissue plasminogen activator toxicity was found in the rabbit retina at a dose of 25 to 50 micrograms/0.1 ml. Subretinal hemorrhage cleared faster after subretinal injection of tissue plasminogen activator when compared to balanced salt solution (P = .0005) but did not completely prevent overlying retinal degeneration. Both tissue plasminogen activator and balanced salt solution were found to decrease the toxic effects of subretinal blood on the morphologic characteristics of the rabbit retina, and this effect can be explained at least partly by dilution of the subretinal blood.
Subject(s)
Retinal Hemorrhage/drug therapy , Tissue Plasminogen Activator/therapeutic use , Animals , Blood , Fundus Oculi , Injections , Microscopy, Electron , Ophthalmoscopy , Photoreceptor Cells/ultrastructure , Rabbits , Retina/ultrastructure , Retinal Hemorrhage/pathology , Sodium Chloride/therapeutic use , Time FactorsABSTRACT
Synthetic and nonsynthetic fiber granulomas can be easily diagnosed and treated. This is a case of a child who had a granulomatous inflammation surrounding a filamentous foreign body that was removed and identified by simple histopathologic techniques. The pathologic findings are remarkably similar to the few case reports in the literature. Accurate reporting of these findings may reveal a greater incidence of synthetic and nonsynthetic fiber granulomas.
