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Bioorg Med Chem Lett
; 29(4): 619-622, 2019 02 15.
Article
in English
| MEDLINE
| ID: mdl-30638875
ABSTRACT
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.