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Toxicon ; 60(3): 329-32, 2012 Sep 01.
Article in English | MEDLINE | ID: mdl-22561423

ABSTRACT

Sodium monofluoroacetate was first identified in Dichapetalum cymosum, a South African plant that can cause livestock poisoning and death. After, several other plants also showed to contain this toxin, which leads to the "sudden death". Mascagnia rigida, a well identified poisonous plant, commonly found in northeast of Brazil also cause sudden death in cattle, which shows clinical signs similar to those produced by the ingestion of plants that contain monofluoroacetate. Our aim was to identify the toxic compound present in the aqueous extract of M. rigida. For this purpose, the dried and milled plant was extracted; the extract was lyophilized and submitted to successive chromatographic process, until the desired purity of the active compound was achieved. The study of this material by planar chromatography and by infrared spectrometry indicated that the toxin can be a mixture of mono, di and trifluoroacetate.


Subject(s)
Fluoroacetates/chemistry , Fluoroacetates/isolation & purification , Malpighiaceae/chemistry , Toxins, Biological/chemistry , Toxins, Biological/isolation & purification , Animals , Animals, Domestic , Brazil , Chromatography, Paper , Chromatography, Thin Layer , Malpighiaceae/poisoning , Pesticides/isolation & purification , Plant Poisoning/etiology , Plant Poisoning/veterinary , Spectroscopy, Fourier Transform Infrared
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