Uveitis subtypes in a german interdisciplinary uveitis center--analysis of 1916 patients.

OBJECTIVE: Studies on the epidemiology of uveitis are rare and cohorts are small. We analyzed the frequencies of classified forms of uveitis in all patients at our center. METHODS: We studied 1916 consecutive patients with inflammatory eye disease. Data were analyzed regarding associated systemic disease, infection, ocular syndromes, anatomic localization, age, and sex. RESULTS: In 59.1% of patients, a classified form of uveitis was observed: associated systemic diseases in 43.7%, the most frequent ones sarcoidosis (17.4%) and ankylosing spondylitis (16.8%); ocular syndromes in 34.3%, the most frequent HLA-B27-positive anterior uveitis (AU; 35.1%) and Fuchs uveitis syndrome (FUS; 34.3%); and infections in 22.4%, the most frequent herpetic infections (46.1%) and toxoplasmosis (31.5%). We found AU in 45.4% of patients (15.4% HLA-B27-positive AU and 11.3% FUS), intermediate uveitis in 22.9% (unclassified 53.7% and multiple sclerosis 10.3%), and posterior uveitis in 13.5% (24.7% toxoplasmosis). Panuveitis was diagnosed in 6.2% of cases (Behçet's disease 12.6%; sarcoidosis 10.9%). The remaining 12.0% of cases showed extrauveal manifestations (scleritis, episcleritis, keratitis, optic neuritis, myositis, and orbital inflammation). CONCLUSION: We describe the largest cohort to date of consecutive patients from a specialized uveitis center. The high frequency of classified disease, nearly 60% in our clinic, shows the usefulness of an interdisciplinary approach, oriented on anatomic presentation.

Corneal radii and anterior chamber depth measurements using the IOLmaster versus the Pentacam.

PURPOSE: Corneal radii (R1, R2) and anterior chamber depth are important parameters for biometry and refractive surgery. This study aimed to investigate whether the IOLMaster, a biometric device, and the Pentacam, a rotating Scheimpflug camera, provide comparable results. METHODS: In this prospective study, corneal radii and anterior chamber depth were analyzed in 82 eyes of 41 phakic patients (median age 72 years) using the IOLMaster and Pentacam. Normal distribution was confirmed using the Kolmogorov-Smirnov test. A paired t test was used for statistical analysis. RESULTS: No statistically significant difference was noted for R2 using the Pentacam versus the IOLMaster (P = .40). There was a small statistical difference of 0.03 mm (P < .01) for R1 (corresponding to 0.08 diopters [D]). The IOLMaster measured a mean R1 of 7.87 mm and R2 of 7.67 mm. The Pentacam measured mean R1 of 7.90 mm and R2 of 7.69 mm. For anterior chamber depth values, a small statistically significant difference of 0.05 mm (P < .001) was found (corresponding to 0.01 D). Mean anterior chamber depth measured from the epithelium was 3.20 mm for the IOLMaster and 3.25 mm for the Pentacam. The Bland-Altman plot showed no distorting trends for either variable. CONCLUSIONS: Keratometry and anterior chamber depth were comparable for the two devices. If the axial length is known, the Pentacam can be used as a biometric device.