ABSTRACT
AIM: To compare efficacy and tolerance of polycosanol vs besafibrate in patients with hypercholesterolemia (HCE). MATERIAL AND METHODS: A multicenter controlled double blind randomised trial entered 113 patients with HCE. After 5 weeks of diet the patients were randomised into two groups. 59 patients of group 1 received polycosanol (10 mg/day), 54 patients of group 2 were given besafibrate (400 mg/day) for 8 weeks. RESULTS: The 8-week course of treatment was completed by 103 patients (91%): 57(97%) patients of group 1 and 46(85%) patients of group 2. In group 1 total cholesterol diminished by an average of 15%, LDLP cholesterol fell by 18%, triglycerides by 15%, while in group 2 a respective decrease was 8, 11 and 6%. Side effects in group 1 were mild. CONCLUSION: A hypolipidemic effect of polycosanol in a daily dose 10 mg is superior to that of besafibrate in a daily dose 400 mg.
Subject(s)
Fatty Alcohols/therapeutic use , Hypolipidemic Agents/therapeutic use , Double-Blind Method , Female , Humans , Hyperlipoproteinemia Type II/drug therapy , Hypolipidemic Agents/adverse effects , Male , Middle Aged , RussiaABSTRACT
The paper provides measurements of maximal Na+, K(+)-ATPase activity in 20 patients with hypertensive disease, 20 patients with secondary hypertension and 20 healthy donors. The investigation was made by high-resolution nuclear magnetic resonance using sodium nuclei. A significant decrease was found in Na+, K(+)-ATPase activity in the patients with hypertensive disease (9.0 +/- 0.3 mg-equiv. per lites cells an hour) as compared with those with secondary hypertension (10.3 +/- 0.3 mg-equiv. per liter cells an hour) and the controls (10.5 +/- 0.3 mg-equiv. per liter cells an hour), which supports the findings of impaired membrane morphology in hypertensive disease.
Subject(s)
Erythrocytes/enzymology , Hypertension, Renal/enzymology , Hypertension/enzymology , Magnetic Resonance Spectroscopy , Sodium-Potassium-Exchanging ATPase/blood , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , SodiumABSTRACT
The method for 23Na NMR measurement of the maximal rate of active Na+ efflux from human red blood cells (RBC) is proposed. The nonpenetrating paramagnetic shift reagent (SR) bis(tripolyphosphate)dysprosium(III) complex is used to distinguish extracellular Na+ ions from intracellular. RBC are proved to retain their physiological activity in the presence of SR. Intracellular Na+ is shown to be 100% NMR visible. The levels of intracellular and extracellular Na+ and K+ ions are changed to decrease their concentration gradients across the erythrocyte membrane to make active Na+ efflux the only 23Na NMR measurable process; so the integrated areas of intra- and extracellular Na+ peaks remain invariant throughout the incubation period in the presence of 0.25 mM ouabain, a specific inhibitor of Na+, K+-ATPase. The accuracy of the proposed technique is evaluated to be 10%. The maximal Na+ efflux is determined to be 10.1 +/- 1.0 mM/h/liter of cells.