ABSTRACT
Chronic 6-month experiment was carried out in rats, which received drinking water with multi-walled carbon nanotubes (MWCNTs), diameter of 15-40 nm, length ≥ 2 mkm) or activated charcoal (AC, diameter of 10-100 mkm), blood samples of the animals were used for assessment of biochemical markers. Both coal compounds induced the appearance of signs of oxidative stress 2 weeks after the beginning of the experiment and alteration of serum markers of liver and renal damage, as well as changes of cortisol and protein serum concentrations later Thus, despite of known high (asbest-like) inhalation toxicity of carbon nanotubes in comparison with other carbon allotrops (fullerenes and black carbon), we have found similar effects of MWCNTs and carbon microparticles in orally treated rats.
Subject(s)
Biomarkers/blood , Charcoal/toxicity , Nanotubes, Carbon/toxicity , Oxidative Stress/drug effects , Water Pollutants, Chemical/toxicity , Administration, Oral , Animals , Drinking Water/chemistry , Kidney/drug effects , Kidney/metabolism , Liver/drug effects , Liver/metabolism , Rats , Toxicity Tests, ChronicABSTRACT
New biomarkers of effect of some controlled ambient air pollutants (formaldehyde, carbon monoxide and TSP) were found in two surveys of Moscow residents (apparently healthy and outpatients with allergic diseases) with a help of screening system of biochemical and immunological parameters. Possible mechanisms of the effects, including interference of atmospheric carbon monoxide and sulfur dioxide with corresponding endogenous second messengers, are discussed.
Subject(s)
Biomarkers/analysis , Environmental Illness/epidemiology , Immunity , Particulate Matter/adverse effects , Population Surveillance/methods , Public Health , Urban Population , Adult , Environmental Health , Environmental Illness/diagnosis , Environmental Illness/metabolism , Female , Humans , Incidence , Male , Middle Aged , Moscow/epidemiology , Retrospective Studies , Young AdultABSTRACT
The complex of urban air pollutants was established to affect the cytokine profile in Moscow residents with chronic obstructive pulmonary disease (COPD)), as it causes a significant reduction of L-6 and TNF-alpha in their blood samples. The identified changes indicate to inhibition of the functional activity of cells of the reticuloendothelial system, which can lead to the persistence of seasonal bacterial-viral infections and more rapid chronization of the basic disease.
