[Marriage and Migratory Characteristic of Circassians (Late 20th Century)].

This paper analyzes 2052 marriage records for 1990-2000 in the Khabezsky district of Karachay-Cherkessia. The main marriage and migration characteristics of Circassians are studied: index of endogamy, ethnic mar- riage assortativity, intensity of metisation, and Malecot's parameters of isolation by distance.

[Ethnic Marriage Assortativeness and Intensity of Metisation of Karachays].

On the basis of 11,280 marriage records of four regions of Karachay-Cherkessia (Karachaevsky, Malokarachaevsky, Ust-Dzhegutinsky, Prikubansky, 193.2 thousand people in total) for 1990-2000, the intensity of Karachay cross-breeding was determined, amounting to 11.7%. Comparison of the intensity of Karachay cross-breeding with that for some other ethnoses is carried out. The ethnic assortativness H is approximately one. The population is characterized a preference for monoethnic marriages. The endogamy index in the studied regions varies from 0.29 to 0.53; after the exclusion from the analysis of repatriates, it increases to 0.34-0.63. The values of local inbreeding in an interval are 0.0001-0.0004, and no differences in terms of isolation by distance are revealed among the regions (0.01). The average square migration is 40-60 km.

Genotoxicity of single-walled carbon nanotubes: in vitro study on human embryonic fibroblast cells.

The effects of single-walled carbon nanotubes on the levels of DNA aberrations, chromosome and genome disorders were studied on human embryonic fibroblasts, their karyotype was analyzed by the spectral karyotyping method. The level of DNA aberrations increased after 3-h exposure to the nanotubes. No appreciable increase in the incidence of aberrant metaphases, micronuclei, and chromosome 1, 6, 8, 11, X, and Y aneuploidy after 24- and 48-h incubation with the nanotubes were detected.

[Population and Genetic Characteristics of Abazins in Karachay-Cherkessia (Marital Migrations and Surname Frequency Distribution)].

Within the framework of a complex medical population genetic study of the population of Karachay-Cherkessia, the standard population genetic characteristics for Abazins were calculated and analyzed: the endogamy index (no more than 0.60), Barrai's parameters (l(r) = 0.0070, v = 0.0131, α = 143.5, H = 8.09, R = 39.65), ethnic assortativeness A (from 0.84 in the Kubina aul to 3.58 in Cherkessk), estimates of Maléco's isolation by distance parameters, and values of random inbreeding (0.0018).

[Acceptability of using Karachay surnames as a quasigenetic marker in population and genetic studies].

Based on a comparison of the data on the frequencies of 1206 surnames registered in the Malokarachayevsky District of Karachay-Cherkessia with a number of other parameters and historical data, it was concluded that Karachay surnames are acceptable for use as a quasigenetic marker in a study of a population-genetic description of the area.

Potential mutagenicity, embryotoxicity, and teratogenicity of calcium ketopantoyl aminobutyrate.

We studied mutagenic, embryotoxic, and teratogenic properties of calcium ketopantoyl aminobutyrate, a preparation proposed as a new drug. Long-term oral administration of calcium ketopantoyl aminobutyrate produced no mutagenic, embryotoxic, and teratogenic effects.