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1.
Rev Mal Respir ; 35(9): 959-962, 2018 Nov.
Article in French | MEDLINE | ID: mdl-30220490

ABSTRACT

INTRODUCTION: Aeromonas pneumonia associated with near-drowning, though uncommon, is serious and a major morbidity factor for patients. CLINICAL CASE: A healthy 30-year-old man nearly drowned in a pound. He was admitted to the medical intensive care unit and required intubation and mechanical ventilation. He was given antibiotic therapy in the form of amoxicillin/clavulanic acid. After a brief stable period post immersion, he rapidly developed fever and respiratory failure. The thoracic scan revealed bilateral alveolar infiltrates and led to a fibreoptic bronchoscopy. Aeromonas veroniiandPseudomonas aeruginosa were found on culture of the bronchial aspirate. A change of antibiotic therapy appropriate to these bacteria led to clinical improvement and allowed complete withdrawal of ventilation. CONCLUSION: Rapid respiratory deterioration following near-drowning should raise the suspicion of pulmonary infection with the bacteria usually found in the respiratory tract during ventilation but without overlooking the possibility of unusual organisms, particularly Aeromonas.It is usuallysensitive to third generation cephalosporins and fluoroquinolones. Ideally, Aeromonas should be sought in pulmonary aspirates and samples of the water where immersion occurred.


Subject(s)
Aeromonas/isolation & purification , Gram-Negative Bacterial Infections/diagnosis , Near Drowning/complications , Near Drowning/microbiology , Pneumonia, Bacterial/diagnosis , Adult , Gram-Negative Bacterial Infections/etiology , Gram-Negative Bacterial Infections/microbiology , Humans , Male , Pneumonia, Bacterial/etiology , Pneumonia, Bacterial/microbiology
2.
Rev Mal Respir ; 33(6): 460-73, 2016 Jun.
Article in English | MEDLINE | ID: mdl-26868668

ABSTRACT

INTRODUCTION: Type 1 neurofibromatosis is one of the most common genetic diseases, with an incidence of 1/3500 live births. Its diagnosis primarily relies on the clinical features of the condition. CURRENT KNOWLEDGE: The life expectancy of these patients is reduced by 10 years, on average, compared to the general population. Type 1 neurofibromatosis has been shown to increase the risk of various types of neoplasia, primarily those affecting the neural crest. In addition, interstitial lung disease, lung cancer, and pulmonary hypertension have been observed during the third or the fourth decade of an adult's life. PERSPECTIVES: There are only few case reports available that address the pulmonary complications of neurofibromatosis type 1. It is thus crucial to fully understand this rare disease and its potential complications in order to allow for early diagnosis so we are able to improve the quality of life and survival of those suffering from the condition. CONCLUSIONS: The pulmonary complications of type 1 neurofibromatosis can be severe and life-threatening. Patients with this condition should thus undergo regular clinical visits and examinations to allow pulmonary complications to be detected and treatment to be initiated as early as possible.


Subject(s)
Lung Diseases/etiology , Neurofibromatosis 1/complications , Humans , Hypertension, Pulmonary/diagnosis , Hypertension, Pulmonary/etiology , Lung Diseases/diagnosis , Lung Diseases, Interstitial/diagnosis , Lung Diseases, Interstitial/etiology , Lung Neoplasms/diagnosis , Lung Neoplasms/etiology , Neurofibromatosis 1/diagnosis , Neurofibromatosis 1/genetics , Rare Diseases
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