ABSTRACT
Andean Berry (Vaccinium meridionale Sw.) is a South American fruit rich in phytochemicals with promising anti-cancer properties as co-adjuvants to nonsteroidal anti-inflammatory drugs such as Aspirin. This study aimed to evaluate the antiproliferative potential of Andean Berry Juice (ABJ) in combination with Aspirin in human SW480 colon adenocarcinoma cells. ABJ primarily contained 3,4-dihydroxybenzoic and chlorogenic acids. The combined treatment of ABJ (IC50 : 30.0 ± 0.11%) and Aspirin (IC50 : 20.0 ± 0.57) exhibited a higher (p < .01) antiproliferative effect than each counterpart. Moreover the same mixture displayed a lower reduced glutathione/oxidized glutathione ratio (GSH/GSSG) than the untreated cells. ABJ-Aspirin combination induced late apoptosis stage without stimulating mitochondrial depolarization and prompted phosphatidylserine relocalization. These results emphasize the antiproliferative potential of bioactive compounds from ABJ and Aspirin combinations. PRACTICAL APPLICATIONS: Natural products such as Andean Berry (V. meridionale Sw.) juice (ABJ) contains antioxidant polyphenols that could reduce the need to use non-steroidal anti-inflammatory drugs, currently employed in cancer treatment, to prevent its side effects. The high abundance of polyphenols from this underutilized berry could stimulate the standardization of its production and industrial exploitation to be transformed into suitable food products delivering natural bioactive compounds with potential anti-cancer effects in vitro.
Subject(s)
Adenocarcinoma , Vaccinium , Adenocarcinoma/drug therapy , Aspirin , Colon , Fruit , HumansABSTRACT
Background: Andean berry (Vaccinium meridionale Swartz) is a native Colombian berry with potential health benefit comparable to cranberry (Vaccinium macrocarpon), both rich in phenolic compounds with a wide range of biological activities. Objectives: to evaluate the effect of Andean berry consumption on blood biochemical parameters (lipid profile and glucose), anthropometric parameters (body weight, waist circumference, body mass index or BMI) and blood pressure of overweight adults. Methods: glycemia, total cholesterol, LDL-cholesterol, HDL-cholesterol and total triglycerides in blood serum, body weight, size and waist perimeter, and blood pressure were analyzed in 25 overweight adults at day 1 and 21 after consumption of 35 g/day of osmodehydrated Andean berry. Results: a significant reduction in diastolic blood pressure (10%, p = 0.0388), systolic blood pressure (6%, p = 0.0400), BMI (1.7%, p = 0.0306), weight (2%, p = 0.0388) and waist circumference (4.1%, p = 0.0052) were observed in the participants who completed the study. However, the lipid profile did not have a significant effect, the glycemia increased significantly (6.9%, p = 0.0004). Conclusions: the results of the present study suggest that the regular consumption of Andean berry treated by osmotic dehydration is a food that may help control weight and blood pressure; however, it requires another type of osmotic agent to prevent the increase of glycemia.
Antecedentes: Agraz (Vaccinium meridionale Swartz) es una baya nativa colombiana con potencial beneficio en la salud comparable al arándano (Vaccinium macrocarpon), ambas ricas en compuestos fenólicos con amplio rango de actividades biológicas. Objetivo: evaluar el efecto del consumo de agraz osmodeshidratado en parámetros bioquímicos sanguíneos (perfil lipídico y glucemia), antropométricos, (perímetro de cintura, índice de masa corporal o IMC) y presión arterial en adultos con sobrepeso Métodos: se analizaron los parámetros glucosa, colesterol total, colesterol-LD, colesterol-HDL, triglicéridos totales en suero, peso, talla y perímetro de cintura, y presión arterial de adultos con sobrepeso al inicio y 21 días después de consumir 35g de agraz osmodeshidratado/día. Resultados: se observó en los participantes que completaron el estudio una reducción significativa en la presión arterial diastólica (10%, p = 0,0388) y sistólica (6%, p = 0,0400), así como en el índice de masa corporal (1,7%, p = 0,0306), peso (2%, p = 0,0388) y perímetro de cintura (4,1%, p = 0,0052). Sin embargo, en el perfil lipídico no tuvo efecto significativo, aunque si aumentó significativamente el valor de la glicemia (6,9%, p = 0,0004). Conclusión: los resultados del presente estudio sugieren que el consumo regular de agraz tratado por deshidratación osmótica es un alimento que ayuda al control del peso y presión arterial, sin embargo requiere otro tipo de agente osmótico para evitar el aumento de la glicemia.
