ABSTRACT
We compared hemostimulating activity of glycyram and a preparation of D-glucuronic acid on the model of granulocytic hemopoiesis suppressed by 5-fluorouracil. Different mechanisms were shown to underlie activation of hemopoiesis by the above preparations: D-glucuronic acid directly affects hemopoietic cells, while glycyram modulates local mechanisms regulating hemopoiesis.
Subject(s)
Anti-Inflammatory Agents/pharmacology , Glucuronic Acid/pharmacology , Glycyrrhetinic Acid/pharmacology , Granulocytes/drug effects , Hematopoiesis/drug effects , Animals , Cell Differentiation/drug effects , Cell Proliferation/drug effects , Cytokines/biosynthesis , Fluorouracil/pharmacology , Mice , Mice, Inbred CBA , Stem Cells/drug effects , Stem Cells/metabolismABSTRACT
A mixture of diterpene alkaloids of Aconitum baicalense exhibited pronounced regenerative hemostimulating properties on the model of cytostatic myelosuppression. The therapeutic effect is based on activation of hemopoietic progenitor cells against the background of increased feeder capacity of stromal compartment of the hemopoiesis-inducing microenvironment and decreased count of mesenchymal stem cells in the bone marrow.
