ABSTRACT
As an important component in medical applications, dosimetry, and radiotherapy studies, the effective atomic number of body tissue, tissue equivalent substances, and dosimetry compounds are investigated. In this research, considering the Coulomb interaction of charged particles, using the collision stopping power and the NIST library data, the effective atomic number of various materials at different energies is calculated for common radiotherapy particles such as electron, proton, alpha, and carbon ions. Taking into account the direct calculation method based on the collision stopping power, the effective atomic number for electron, proton, alpha, and carbon particles is determined for a group of dosimetry and tissue equivalent materials. Results of the calculations based on the collision stopping power showed that in low kinetic energy, the values of the effective atomic number are equal to the total number of electrons in each molecule of the compound, which is quite justified by the physics of Bethe's formulas.
ABSTRACT
In this paper, the dosimetric characteristics of a colored metal complex solution were investigated. Nickel nitrate hexahydrate and 1,5-diphenylcarbazone were made as a liquid solution chemical dosimeter at three concentrations with an inexpensive and simple synthesis for use in gamma irradiation in the range of 20-1000 Gy. The maximum absorbance was observed spectrophotometrically at a maximum wavelength of 530 nm. The paper presents the dosimeter response, radiation chemical yield (G(x)), stability, and repeatability. The results showed that this solution is suitable for use in routine dosimetry in the 20-1000 Gy range.
ABSTRACT
This study proposes an innovative approach to estimate relative biological effectiveness (RBE) of fast neutrons using the Geant4 toolkit. The Geant4-DNA version cannot track heavy ions below 0.5 MeV/nucleon. In order to explore the impact of this issue, secondary particles are simulated instead of the primary low-energy neutrons. The Evaluated Nuclear Data File library is used to determine the cross sections for the elastic and inelastic interactions of neutrons with water and to find the contribution of each secondary particle spectrum. Two strategies are investigated in order to find the best possible approach and results. The first one takes into account only light particles, protons produced from elastic scattering, and α particles from inelastic scattering. Geantino particles are shot instead of heavy ions; hence all heavy ions are considered in the simulations, though their physical effects on DNA not. The second strategy takes into account all the heavy and light ions, although heavy ions cannot be tracked down to very low energies (E<0.5 MeV/nucleon). Our model is based on the combination of an atomic resolution DNA geometrical model and a Monte Carlo simulation toolkit for tracking particles. The atomic coordinates of the DNA double helix are extracted from the Protein Data Bank. Since secondary particle spectra are used instead of simulating the interaction of neutrons explicitly, this method reduces the computation times dramatically. Double-strand break induction is used as the end point for the estimation of the RBE of fast neutrons. ^{60}Co γ rays are used as the reference radiation quality. Both strategies succeed in reproducing the behavior of the RBE_{max} as a function of the incident neutron energy ranging from 0.1 to 14 MeV, including the position of its peak. A comparison of the behavior of the two strategies shows that for neutrons with energies less than 0.7 MeV, the effect of heavy ions would not be very significant, but above 0.7 MeV, heavy ions have an important role in neutron RBE.
