ABSTRACT
In a prospective investigation, a rapid latex test for Helicobacter pylori in the serum (Pyloriset) was carried out in 39 patients with recurrent abdominal pain aged from six to 15 years. The test was positive in 19 patients. All of these children were subjected to gastroduodenoscopy. Seven cases showed a Helicobacter-associated chronic active antrum gastritis, whereas in the remaining 12 children gastritis not induced by Helicobacter or normal mucosa was found. Of the 20 Pyloriset-negative patients, only five could be biopsied. One of these showed a Helicobacter pylori-induced antrum gastritis. The latex test investigated had a positive predictive value which was too low (37%) to make it helpful in deciding for or against gastroduodenoscopy and the general anesthesia mostly associated with this.
Subject(s)
Abdominal Pain/etiology , Gastritis/diagnosis , Helicobacter Infections/diagnosis , Helicobacter pylori , Latex Fixation Tests , Abdominal Pain/microbiology , Adolescent , Child , Chronic Disease , Diagnosis, Differential , Endoscopy, Digestive System , Female , Gastritis/complications , Gastritis/microbiology , Helicobacter Infections/complications , Helicobacter Infections/microbiology , Humans , Male , Predictive Value of TestsABSTRACT
We report on a severe, generalized cytomegaly-virus-infection of a neonate with typical clinical symptoms and features. An attempt to treat with the antiviral drug Ganciclovir, an acyclic nucleoside analogue of guanine is described.
Subject(s)
Cytomegalovirus Infections/congenital , Ganciclovir/administration & dosage , Antibodies, Viral/analysis , Cytomegalovirus/immunology , Cytomegalovirus Infections/drug therapy , Cytomegalovirus Infections/immunology , Ganciclovir/adverse effects , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Infant, Newborn , Infusions, Intravenous , Liver Function Tests , Male , Virus CultivationABSTRACT
In all neonates delivered at the Steyr Landeskrankenhaus from 1987 to 1989, immunreactive trypsin (IRT) in the umbilical cord blood was determined to enable early diagnosis of mucoviscidosis (cystic fibrosis, CF). Amongst 4,507 neonates 75 were found in whom the IRT was over the cut-off value of 1,204 ng/ml. Of these babies, 69 were presented at the age of six weeks for determination of elecrolytes in their sweat. Mucoviscidosis could be diagnosed in two patients. The sensitivity of our test is likely to be 100%. There is no question that the specificity (98.38%) requires improvement. The incidence of mucoviscidosis in our catchment area is 1: 2,254. The hypertrypsinemia detected was probably transient in 73 babies. Ten of these patients showed a one-minute Apgar score of less than seven.
