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1.
Eur J Nutr ; 61(7): 3357-3366, 2022 Oct.
Article in English | MEDLINE | ID: mdl-35505122

ABSTRACT

PURPOSE: This study aimed to investigate the effects of AGE on microvascular reactivity, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in older individuals at high risk for cardiovascular disease (CVD). Urinary thiosulfate was also investigated as an indirect marker of endogenous hydrogen sulfide (H2S) synthesis. The study was conducted in a randomized, double-blind, crossover, and placebo-controlled way. METHODS: Twenty-eight participants (14 male), 67 ± 6 years old with CVD risk factors, ingested 2.4 g of AGE or placebo (PLA). Near-infrared spectroscopy evaluated tissue oxygen saturation (StO2) during a vascular occlusion test (30 s baseline, 5 min occlusion, and 2 min reperfusion). The upslope of StO2 signal after cuff release was calculated to measure microvascular reactivity. Urinary thiosulfate levels were measured using a high-performance liquid chromatography system. RESULTS: The upslope of StO2 was significantly faster after AGE (1.01 ± 0.37% s-1) intake compared to PLA (0.83 ± 0.35% s-1; P < 0.001; d = 0.50). Relative changes in Δ% SBP from pre- to post-AGE intake (- 5.17 ± 5.77%) was significantly different compared to Δ% PLA (0.32 ± 5.99%; P = 0.001; d = 0.93). No significant changes in urinary thiosulfate concentrations were observed between interventions. Moreover, no significant gender effect in any parameter assessed was found. CONCLUSION: This study demonstrated that a single dose of AGE improved microvascular reactivity in older adults at risk of CVD despite such an effect was not linked with urinary thiosulfate levels. This trial was registered at clinicaltrials.gov as NCT04008693 (May 19, 2020).


Subject(s)
Cardiovascular Diseases , Garlic , Hydrogen Sulfide , Aged , Cardiovascular Diseases/prevention & control , Humans , Hydrogen Sulfide/metabolism , Male , Microcirculation/physiology , Middle Aged , Muscle, Skeletal/metabolism , Oxygen Consumption/physiology , Plant Extracts/metabolism , Polyesters/metabolism , Thiosulfates/metabolism
2.
Int J Food Sci Nutr ; 73(2): 274-283, 2022 Mar.
Article in English | MEDLINE | ID: mdl-34551650

ABSTRACT

Ageing is associated with endothelial dysfunction and reduced cerebral blood flow and oxygenation. The present study aimed to investigate whether turmeric supplementation could improve cerebral oxygenation and blood volume during brain activation via dynamic handgrip exercise in older males and females. Twelve older males and females were studied using a double-blind, placebo-controlled, cross-over design. Participants ingested turmeric root extract or placebo. Heart rate and blood pressure were measured before and 2 hours after supplementation. Afterward, the exercise protocol was started, and cerebral oxygenation and blood volume were evaluated. During exercise, changes in cerebral oxygenation were higher after turmeric extract supplementation, as was blood volume compared to placebo. Changes in heart rate, systolic blood pressure, and diastolic blood pressure were not significant. The current findings indicate the potential for curcumin as an intervention for improving cerebral oxygenation and blood volume changes in older males and females. Clinical trial registry: NCT04119752.


Subject(s)
Curcuma , Hand Strength , Aged , Blood Volume , Cross-Over Studies , Dietary Supplements , Double-Blind Method , Female , Frontal Lobe , Humans , Male , Plant Extracts
3.
Article in English | MEDLINE | ID: mdl-32708408

ABSTRACT

The current pool of data investigating the effects of a single resistance exercise session on endothelial function is divergent and inconclusive. Therefore, the purpose of the present study was to evaluate the effect of a single resistance exercise session on flow-mediated dilation (FMD) in trained individuals. Eleven healthy, young, recreationally resistance-trained individuals participated in the study. After determining the resistance exercise workload, the participants performed three sets of 10-12 repetition of leg press and leg extension exercises. By using ultrasound equipment, brachial artery FMD was assessed before (PRE) and 30 min after (POST) the resistance exercise protocol or resting (control) to evaluate endothelial function. A significant reduction in FMD response (PRE: 5.73% ± 1.21% vs. POST: 4.03% ± 1.94%, p < 0.01) after resistance exercise was observed, accompanied by a large effect size (d = 1.05). No significant difference was observed in FMD in the control condition (PRE: 5.82% ± 1.19% vs. POST: 5.66% ± 1.24%, p = 0.704). Additionally, no significant difference in baseline brachial artery diameter between resistance exercise (PRE: 3.30 ± 0.32 vs. POST: 3.40 ± 0.34 mm, p = 0.494) and resting (PRE: 3.64 ± 0.41 vs. POST: 3.67 ± 0.62 mm, p = 0.825) was observed. Our findings showed that a single resistance exercise session induced a reduction in FMD in resistance-trained individuals.


Subject(s)
Brachial Artery/diagnostic imaging , Brachial Artery/physiology , Endothelium, Vascular/physiology , Exercise/physiology , Regional Blood Flow/physiology , Resistance Training , Vasodilation/physiology , Adult , Dilatation , Endothelium, Vascular/diagnostic imaging , Female , Healthy Volunteers , Humans , Male , Ultrasonography , Young Adult
4.
Clín. int. j. braz. dent ; 4(1): 86-92, 2008. ilus
Article in Portuguese | LILACS, BBO - Dentistry | ID: lil-526051

ABSTRACT

O objetivo deste estudo é revisar a literatura sobre as estratégias clínicas para minimizar os efeitos adversos da contração de polimerização dos compósitos, dentre elas, a forma de inserção da resina composta, o uso de materiais intermediários com propriedades elásticas e as técnicas de fotoativação. De acordo com a literatura, a combinação de mais de uma estratégia parece ser o método mais eficiente para garantir o sucesso clínico das restaurações diretas. Além disso, o julgamento crítico do adequado emprego dos compósitos pode influenciar o resultado final do tratamento restaurador.


Subject(s)
Composite Resins , Dental Materials , Dental Restoration, Permanent
5.
JBC j. bras. clin. odontol. integr ; 8(46): 347-351, jul.-set. 2004. ilus
Article in Portuguese | LILACS, BBO - Dentistry | ID: lil-444994

ABSTRACT

Os núcleos metálicos fundidos apresentam desempenho clínico com alta taxa de sucesso, e são considerados uma etapa fundamental para a longevidade das próteses parciais fixas. No entanto, o Clínico deve estar atento aos princípios biomecânicos de sua construção, pois como reportado na literatura, os núcleos fundidos não representam um reforço para o remanescente dental. Deste modo, este artigo tem por objetivo apresentar, através de desenhos esquemáticos acompanhados de radiografias de casos clínicos, as principais falhas que podem ocorrer na utilização dos núcleos metálicos fundidos e os cuidados necessários para evitá-las ou minimizar sua ocorrência


Subject(s)
Denture, Partial, Fixed , Post and Core Technique , Treatment Failure , Biomechanical Phenomena/methods , Dental Prosthesis Retention/methods
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