Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 120
Filter
1.
Br J Radiol ; 84(1007): 997-1004, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21896664

ABSTRACT

OBJECTIVE: Endometrial cancer is the most common gynaecological malignancy in developed countries. Histological grade and subtype are important prognostic factors obtained by pipelle biopsy. However, pipelle biopsy "samples" tissue and a high-grade component that requires more aggressive treatment may be missed. The purpose of the study was to assess the use of diffusion-weighted MRI (DW-MRI) in the assessment of tumour grade in endometrial lesions. METHOD: 42 endometrial lesions including 23 endometrial cancers and 19 benign lesions were evaluated with DW-MRI (1.5T with multiple b-values between 0 and 750 s mm(-2)). Visual evaluation and the calculation of mean and minimum apparent diffusion coefficient (ADC) value were performed and correlated with histology. RESULTS: The mean and minimum ADC values for each histological grade were 1.02 ± 0.29×10(-3) mm(2) s(-1) and 0.74 ± 0.24×10(-3) mm(2) s(-1) (grade 1), 0.88 ± 0.39×10(-3) mm(2) s(-1) and 0.64 ± 0.36×10(-3) mm(2) s(-1) (grade 2), and 0.94 ± 0.32×10(-3) mm(2) s(-1) and 0.72 ± 0.36×10(-3) mm(2) s(-1) (grade 3), respectively. There was no statistically significant difference between tumour grades. However, the mean ADC value for endometrial carcinoma was 0.97 ± 0.31, which was significantly lower (p<0.0001) than that of benign endometrial pathology (1.50 ± 0.14). Applying a cut-off mean ADC value of less than 1.28 × 10(-3) mm(2) s(-1)we obtained a sensitivity, specificity, positive predictive value and negative predictive value for malignancy of 87%, 100%, 100% and 85.7%, respectively. CONCLUSION: Tumour mean and minimum ADC values are not useful in differentiating histological tumour grade in endometrial carcinoma. However, mean ADC measurement can provide useful information in differentiating benign from malignant endometrial lesions. This information could be clinically relevant in those patients where pre-operative endometrial sampling is not possible.


Subject(s)
Diffusion Magnetic Resonance Imaging , Endometrial Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Endometrial Neoplasms/diagnosis , Female , Humans , Middle Aged , Neoplasm Grading , Observer Variation , Retrospective Studies , Sensitivity and Specificity
2.
Eur J Endocrinol ; 162(5): 971-8, 2010 May.
Article in English | MEDLINE | ID: mdl-20207727

ABSTRACT

CONTEXT: Preoperative localisation of insulinoma improves cure rate and reduces complications, but may be challenging. OBJECTIVE: To review diagnostic features and localisation accuracy for insulinomas. DESIGN: Cross-sectional, retrospective analysis. SETTING: A single tertiary referral centre. PATIENTS: Patients with insulinoma in the years 1990-2009, including sporadic tumours and those in patients with multiple endocrine neoplasia syndromes. INTERVENTIONS: Patients were identified from a database, and case notes and investigation results were reviewed. Tumour localisation by computed tomography (CT), magnetic resonance imaging (MRI), octreotide scanning, endoscopic ultrasound (EUS) and calcium stimulation was evaluated. MAIN OUTCOME MEASURE(S): Insulinoma localisation was compared to histologically confirmed location following surgical excision. RESULTS: Thirty-seven instances of biochemically and/or histologically proven insulinoma were identified in 36 patients, of which seven were managed medically. Of the 30 treated surgically, 25 had CT (83.3%) and 28 had MRI (90.3%), with successful localisation in 16 (64%) by CT and 21 (75%) by MRI respectively. Considered together, such imaging correctly localised 80% of lesions. Radiolabelled octreotide scanning was positive in 10 out of 20 cases (50%); EUS correctly identified 17 lesions in 26 patients (65.4%). Twenty-seven patients had calcium stimulation testing, of which 6 (22%) did not localise, 17 (63%) were correctly localised, and 4 (15%) gave discordant or confusing results. CONCLUSIONS: Preoperative localisation of insulinomas remains challenging. A pragmatic combination of CT and especially MRI predicts tumour localisation with high accuracy. Radionuclide imaging and EUS were less helpful but may be valuable in selected cases. Calcium stimulation currently remains useful in providing an additional functional perspective.


Subject(s)
Calcium , Insulinoma/diagnosis , Magnetic Resonance Imaging/methods , Adult , Aged , Endosonography , Female , Humans , Insulinoma/diagnostic imaging , Insulinoma/surgery , Male , Middle Aged , Octreotide , Pancreatic Neoplasms/diagnosis , Pancreatic Neoplasms/diagnostic imaging , Pancreatic Neoplasms/surgery , Retrospective Studies , Tomography, X-Ray Computed
3.
Cancer Biomark ; 5(2): 81-8, 2009.
Article in English | MEDLINE | ID: mdl-19414925

ABSTRACT

Lymph node status determines both prognosis and treatment choice in gynecological malignancies. Both CT and MRI are standard techniques used to detect lymph node involvement but these techniques have low sensitivity and specificity. Magnetic resonance lymphography (MRL) using iron oxide nanoparticles is a new technique for lymph node assessment which has shown much promise. This article discusses the applications of MRL in the setting of gynecological malignancy.


Subject(s)
Genital Neoplasms, Female/diagnosis , Lymph Nodes/pathology , Lymphography/methods , Magnetic Resonance Imaging/methods , Clinical Trials as Topic , Dextrans , Female , Ferrosoferric Oxide , Genital Neoplasms, Female/pathology , Humans , Iron , Magnetite Nanoparticles , Nanoparticles , Oxides , Positron-Emission Tomography , Tomography, X-Ray Computed
4.
Clin Radiol ; 64(4): 430-8, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19264189

ABSTRACT

This review was performed to describe the range of magnetic resonance imaging (MRI) appearances of borderline ovarian tumours. The MRI findings in 26 patients with 31 borderline ovarian tumours (mean age: 40.1 years, range: 14-85 years) were retrospectively reviewed. For each tumour, site, size, MRI characteristics, and enhancement following gadolinium administration were recorded. There were 20 serous and 11 mucinous borderline ovarian subtypes. Nine of 26 patients demonstrated bilateral disease on MRI; synchronous contralateral ovarian disease included three benign, five serous borderline, and one serous invasive tumour. A history of a metachronous mucinous borderline tumour was identified in one patient. MRI appearances were classified into four morphological categories: group 1 (6/31, 19%), unilocular cysts; group 2 (6/31, 19%), minimally septate cysts with papillary projections; group 3 (14/31, 45%), markedly septate lesions with plaque-like excrescences; and group 4 (5/31, 16%), predominantly solid with exophytic papillary projections, all of serous subtype. There was a significant difference in mean volume between serous (841.5 cm(3)) and mucinous (6358.2 cm(3)) subtypes (p=0.009). All tumours demonstrated at least one MRI feature suggestive of malignancy. The present review demonstrates the variable MRI appearances of borderline ovarian tumours along with imaging features suggestive of tumour subtype. In patients in whom the clinical features are suggestive of a borderline ovarian tumour (young age and normal or minimally elevated CA125), the ability to predict a borderline disease using morphological features observed on MRI would be extremely helpful in surgical planning, with the potential to offer fertility or ovary-preserving surgery. Future studies are required to further this aim.


Subject(s)
Magnetic Resonance Imaging , Ovarian Neoplasms/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Diagnosis, Differential , Female , Gadolinium , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging/methods , Middle Aged , Ovarian Neoplasms/classification , Ovarian Neoplasms/diagnosis , Radioisotopes , Retrospective Studies , Young Adult
5.
Neuroendocrinology ; 89(3): 288-95, 2009.
Article in English | MEDLINE | ID: mdl-19023191

ABSTRACT

PURPOSE: The sensitivity of computerised tomography (CT) in detecting neuroendocrine liver metastases is variable and three-phase imaging is advocated. However, patients are often young and may require prolonged follow-up, thus a technique that avoids radiation exposure would be desirable. Our purpose was to assess the diagnostic performance of MRI, before and after administration of mangafodipir trisodium (MnDPDP), in the detection of neuroendocrine liver metastases. METHODS: Patients who had undergone single-phase or multi-phase contrast-enhanced MD-CT for neuroendocrine liver metastases were invited to have MRI. Two independent observers made quantitative measurements (number and size of lesions). All measurements were made on each available CT phase and all MRI sequences independently, and repeated after an interval to assess reproducibility. The final number of lesions was agreed on by consensus of three observers. A qualitative assessment (contrast and spatial resolution) and preferred modality were agreed on by consensus. RESULTS: 265 lesions were detected by consensus in 11 patients. Non-contrast CT was available in 4/11, arterial phase in 6/11 and portal phase in 10/11 patients. When compared with the consensus number of lesions, MD-CT identified 17% on non-contrast, 44% on arterial and 43% on portal venous imaging. Lesion detection on MRI was 48% on T(1)W, 52% on T(2)W and 92% on MnDPDP-MRI. The number of lesions detected on MnDPDP-MRI was closest to the final consensus reading (variance = 0.994, p = 0.0027). The reproducibility of lesion size measurements was best on MnDPDP-MRI (variance = 0.033, p = 0.0021). The preferred modality subjectively was MnDPDP-MRI in 9/11 cases and T(2)W MRI in 2/11. CONCLUSION: MRI is a robust technique in the demonstration of neuroendocrine liver metastases. It is highly reproducible in both detecting the number and measuring the size of lesions. We recommend T(2)W MRI and MnDPDP-MRI in detection and follow-up of neuroendocrine liver metastases.


Subject(s)
Contrast Media , Edetic Acid/analogs & derivatives , Liver Neoplasms/diagnosis , Liver Neoplasms/secondary , Magnetic Resonance Imaging/methods , Neuroendocrine Tumors/pathology , Neuroendocrine Tumors/secondary , Pyridoxal Phosphate/analogs & derivatives , Adult , Aged , Female , Humans , Iohexol , Male , Middle Aged , Tomography, X-Ray Computed/methods
6.
Eur J Endocrinol ; 159(6): 819-24, 2008 Dec.
Article in English | MEDLINE | ID: mdl-18827064

ABSTRACT

AIMS: To review the morphology of the adrenal glands in multiple endocrine neoplasia type 1 (MEN1) on computed tomography (CT) to compare the results with established normal values for adrenal size and nodularity and to correlate adrenal size with serum cortisol secretory dynamics. MATERIALS AND METHODS: Two observers independently reviewed the adrenal CT in 28 patients with MEN1, measuring the maximum width of the body of the gland and the medial and lateral limbs. Incidence and location of nodules >5 mm within the gland were recorded. Following exclusion of known cases of Cushing's syndrome, adrenal gland size was compared with previously documented normative data. Adrenal gland size was compared between patients with normal and abnormal cortisol dynamics. RESULTS: Comparison of mean adrenal size in MEN1 patients with normative data showed that the adrenal limbs were significantly larger in MEN1 than normal (P<0.0001 in all four limbs). Adrenal body was also significantly larger (P<0.05). Nodules were demonstrated in 17 (60%) of patients (versus 0.4-2% in the normal population). No statistically significant correlation was demonstrated between adrenal limb hyperplasia and abnormal cortisol dynamics. CONCLUSIONS: In patients with MEN1, adrenal limb hyperplasia and adrenal nodules are significantly more common than in the normal population, a phenomenon not previously documented in a quantitative manner. There was no significant correlation between adrenal limb hyperplasia and abnormal cortisol dynamics.


Subject(s)
Adrenal Glands/diagnostic imaging , Multiple Endocrine Neoplasia Type 1/diagnostic imaging , Tomography, X-Ray Computed , Adrenal Glands/drug effects , Adult , Aged , Aged, 80 and over , Cohort Studies , Dexamethasone/administration & dosage , Female , Humans , Hydrocortisone/blood , Male , Middle Aged , Multiple Endocrine Neoplasia Type 1/blood , Multiple Endocrine Neoplasia Type 1/drug therapy , Retrospective Studies , Tomography, X-Ray Computed/methods
7.
Acta Radiol ; 48(9): 1038-44, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17957523

ABSTRACT

BACKGROUND: Although the sites of recurrent ovarian cancer are individually described in the literature, patterns of recurrent disease are poorly understood. PURPOSE: To describe CT patterns of disease in recurrent ovarian cancer. To emphasize common patterns, recognise subtle and unusual sites of recurrent disease. MATERIALS AND METHODS: We identified patients between 1981-2004 presenting with clinical recurrence or elevated CA 125 after complete primary clinical and radiological response. CT imaging at primary diagnosis, during and after treatment and at recurrence was retrospectively reviewed. Site, distribution, stage of disease and time to relapse was recorded. RESULTS: 400 patients were treated for ovarian cancer. 214(54%) achieved complete primary response. 161(75%) relapsed with complete imaging available in 67 patients. Of the 67 patients, 14 (21%) recurred within 1 year, 44 (66%) relapsed between 1-5 years. Therefore 87% of relapses occurred within 5 years following primary treatment. Five (8%) relapsed between 5-10 years and 4 (6%) relapsed after 10 years. Commonest pattern of relapse was pelvic mass in 35 (48%) patients, solitary in 15 (22%). 27 (45%) relapsed with peritoneal thickening, 27 (45%) had small or large bowel serosal disease, 22 (33%) had enlarged lymphadenopathy, 6 as sole manifestation of recurrence, 20 (30%) presented with unusual sites of recurrence: 6 splenic, 10 hepatic, 2 biliary, 3 brain and 2 muscle. CONCLUSION: Our study is the first to describe common patterns of recurrence in ovarian cancer. Most frequent site is pelvis, followed by peritoneum, serosal surfaces and nodal disease. 30% presented with disease at 'unusual' sites.


Subject(s)
Ovarian Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Adult , Contrast Media , Female , Humans , Middle Aged , Neoplasm Recurrence, Local/diagnostic imaging , Ovarian Neoplasms/pathology , Ovarian Neoplasms/therapy , Retrospective Studies , Statistics, Nonparametric , Time Factors
8.
Cancer Imaging ; 7 Spec No A: S100-9, 2007 Oct 01.
Article in English | MEDLINE | ID: mdl-17921094

ABSTRACT

With the increasing use of abdominal cross-sectional imaging, incidental adrenal masses are frequently detected. The commonest clinical question is whether these are benign adenomas or malignant primary or secondary masses. The nature of incidentally detected adrenal masses can be determined with a high degree of accuracy using computed tomography (CT) and magnetic resonance imaging (MRI) as benign adrenal masses such as myelolipomas, lipid-rich adenomas, adrenal cysts and adrenal haemorrhage which have pathognomonic imaging findings. However, there remains a significant overlap between the imaging features of some lipid-poor adenomas and malignant lesions. We review the recent advances in CT, MRI and positron emission tomography (PET) which can be used to distinguish between benign adenomas and malignant lesions of the adrenal gland.


Subject(s)
Adrenal Gland Diseases/diagnosis , Neoplasms/pathology , Adrenal Gland Diseases/pathology , Adrenal Gland Neoplasms/diagnosis , Contrast Media , Diagnosis, Differential , Humans , Incidental Findings , Magnetic Resonance Imaging , Radiopharmaceuticals , Tomography, Emission-Computed , Tomography, X-Ray Computed
9.
Cancer Imaging ; 7 Spec No A: S119-29, 2007 Oct 01.
Article in English | MEDLINE | ID: mdl-17921097

ABSTRACT

Magnetic resonance (MR) imaging is increasingly being used in patients with gynaecological disorders due to its high contrast resolution compared to computed tomography (CT) and ultrasound. In women presenting with an adnexal mass, ultrasound remains the primary imaging modality in the detection and characterisation of such lesions. However, in recent years overwhelming evidence has accumulated for the use of MR imaging in patients with indeterminate adnexal masses particularly in younger women and where disease markers are unhelpful. In staging ovarian cancer and for evaluating therapeutic response MR imaging is as accurate as CT but CT remains the imaging modality of choice because it is more widely available and quicker. This article reviews that evidence and outlines a place for the use of MR imaging in ovarian cancer.


Subject(s)
Magnetic Resonance Imaging/methods , Ovarian Neoplasms/diagnosis , Contrast Media , Diagnosis, Differential , Female , Humans , Neoplasm Staging , Ovarian Neoplasms/pathology , Prognosis , Sensitivity and Specificity
10.
Int J Gynecol Cancer ; 17(1): 61-7, 2007.
Article in English | MEDLINE | ID: mdl-17291233

ABSTRACT

A risk of malignancy index (RMI), based on menopausal status, ultrasound (US) findings, and serum CA125, has previously been described and validated in the primary evaluation of women with adnexal masses and is widely used in selective referral of women from local cancer units to specialized cancer centers. Additional imaging modalities could be useful for further characterization of adnexal masses in this group of women. A prospective cohort study was conducted of 196 women with an adnexal mass referred to a teaching hospital for diagnosis and management. Follow-up data was obtained for 180 women; 119 women had benign and 61 women malignant adnexal masses. The sensitivity and specificity of specialist US, magnetic resonance imaging (MRI), radioimmunoscintigraphy (RS), and the RMI were determined. We identified a subgroup of women with RMI values of 25-1000 where the value of further specialist imaging was evaluated. Sensitivity and specificity for specialist US were 100% and 57%, for MRI 92% and 86%, and for RS 76% and 87%, respectively. Analysis of 123 patients managed sequentially, using RMI cutoff values of > or =25 and <1000 and then US and MRI provided a sensitivity of 94% and a specificity of 90%. Using this RMI cutoff followed by specialist US and MRI, as opposed to the traditional RMI cutoff value of 250, can increase the proportion of patients with cancer appropriately referred in to a cancer center, with no change in the proportion of patients with benign disease being managed in a local unit.


Subject(s)
Genital Diseases, Female/diagnosis , Neoplasms, Adnexal and Skin Appendage/diagnosis , Adnexa Uteri/diagnostic imaging , Adnexa Uteri/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Cohort Studies , Diagnosis, Differential , Female , Genital Diseases, Female/diagnostic imaging , Genital Diseases, Female/pathology , Humans , Magnetic Resonance Imaging , Middle Aged , Neoplasms, Adnexal and Skin Appendage/diagnostic imaging , Neoplasms, Adnexal and Skin Appendage/pathology , Prospective Studies , Risk Factors , Sensitivity and Specificity , Ultrasonography
11.
Int J Gynecol Cancer ; 17(1): 188-96, 2007.
Article in English | MEDLINE | ID: mdl-17291252

ABSTRACT

Our aims were to assess diagnostic performance of T2-weighted (T2W) and dynamic gadolinium-enhanced T1-weighted (T1W) magnetic resonance imaging (MRI) in the preoperative assessment of myometrial and cervical invasion by endometrial carcinoma and to identify imaging features that predict nodal metastases. Two radiologists retrospectively reviewed MR images of 96 patients with endometrial carcinoma. Tumor size, depth of myometrial and cervical invasion, and nodal enlargement were recorded and then correlated with histology. The sensitivity, specificity, positive and negative predictive values (PPV and NPV) for the identification of any myometrial invasion (superficial or deep) were 0.94, 0.50, 0.93, 0.55 on T2W and 0.92, 0.50, 0.92, 0.50 on dynamic T1W, and for deep myometrial invasion were 0.84, 0.78, 0.65, 0.91 on T2W and 0.72, 0.88, 0.72, 0.88 on dynamic T1W. The sensitivity, specificity, PPV and NPV for any cervical invasion (endocervical or stromal) were 0.65, 0.87, 0.57, 0.90 on T2W and 0.50, 0.90, 0.46, 0.92 on dynamic T1W, and for cervical stromal involvement were 0.69, 0.95, 0.69, 0.95 on T2W and 0.50, 0.96, 0.57, 0.95 on dynamic T1W. Leiomyoma or adenomyosis were seen in 73% of misdiagnosed cases. Sensitivity and specificity for the detection of nodal metastases was 66% and 73%, respectively. Fifty percent of patients with cervical invasion on MRI had nodal metastases. In conclusion, MRI has a high sensitivity for detecting myometrial invasion and a high NPV for deep invasion. MRI has a high specificity and NPV for detecting cervical invasion. Dynamic enhancement did not improve diagnostic performance. MRI may allow accurate categorization of cases into low- or high-risk groups ensuring suitable extent of surgery and adjuvant therapy.


Subject(s)
Endometrial Neoplasms/pathology , Magnetic Resonance Imaging/methods , Adult , Aged , Aged, 80 and over , Female , Humans , Image Processing, Computer-Assisted , Lymph Nodes/pathology , Lymphatic Metastasis , Middle Aged , Neoplasm Invasiveness , Reproducibility of Results
12.
Int J Gynecol Cancer ; 17(3): 629-36, 2007.
Article in English | MEDLINE | ID: mdl-17309561

ABSTRACT

We report our long-term experience of performance of magnetic resonance imaging (MRI) in localizing cervical tumor, assessing tumor size, staging, and lymph node infiltration in patients with early cervical cancer. MRI of 150 patients with early carcinoma between 1995-2005 was retrospectively reviewed. Tumor location, size, tumor distance from internal os, parametrial invasion, myometrial invasion, lymph node size, and location were documented. All patients underwent surgery, pelvic lymphadenectomy, and histological correlation of MRI findings. For staging, MRI and histopathology had kappa value of 0.89. For parametrial invasion, MRI had specificity, negative predictive value (NPV) of 97% and 100%, respectively. For tumor size, MRI and histology had mean difference of -0.9 mm with 95% limits of agreement between -12.6 to +13 mm. In tumors greater than 10 mm, mean difference was 0.3 mm and limits of agreement were -7.5 to +7.9 mm. For internal os involvement sensitivity, specificity, positive predictive value (PPV) and NPV were 90%, 98%, 86%, 98%. respectively. For myometrial invasion sensitivity, specificity, NPV, and PPV were 100%, 99%, 88%, 100%, respectively. Incidence of nodal metastases was 2.9%. On a per-patient basis, sensitivity, specificity for nodal involvement was 37% and 92% and on node-by-node basis, sensitivity and specificity of MRI was 27% and 99%, respectively. Our study confirms MRI is highly accurate in localizing cervical tumor, excluding parametrial invasion, confirming myometrial and internal os invasion. MRI is therefore useful in selecting patients for surgery and mandatory in patients for fertility-preserving surgery. Using accepted size criteria for nodal involvement, MRI is insensitive and currently will not avoid need for pelvic lymphadenectomy.


Subject(s)
Carcinoma/diagnostic imaging , Magnetic Resonance Imaging , Uterine Cervical Neoplasms/diagnostic imaging , Adult , Carcinoma/pathology , Female , Humans , Lymphatic Metastasis , Middle Aged , Myometrium/pathology , Neoplasm Invasiveness , Neoplasm Staging , Radiography , Retrospective Studies , Sensitivity and Specificity , Tumor Burden , Uterine Cervical Neoplasms/pathology
13.
Clin Radiol ; 62(1): 28-34; discussion 35-6, 2007 Jan.
Article in English | MEDLINE | ID: mdl-17145260

ABSTRACT

AIM: To evaluate patterns of disease and identify factors predicting outcome in patients presenting with recurrent endometrial adenocarcinoma following primary surgery. MATERIALS AND METHODS: A retrospective review was performed of the imaging and clinical data in 86 patients (median age 66 years, range 42-88 years) presenting with recurrent endometrial adenocarcinoma following primary surgery. RESULTS: Following primary surgery recurrent disease occurred within 2 years in 64% and within 3 years in 87%. Relapse was seen within lymph nodes in 41 (46%), the vagina in 36 (42%) the peritoneum in 24 (28%) and the lung in 21 (24%). Unusual sites of disease included spleen, pancreas, rectum, muscle and brain. Univariate survival analysis showed the factors significant for poor outcome were: multiple sites of disease, liver and splenic disease, haematogenous, peritoneal and nodal spread, poorly differentiated tumour, and early relapse. The presence of disease within the vagina, bladder or lung was not associated with poor prognosis. Multivariate analysis identified multiple sites of disease, liver and splenic metastases to be independent predictors of poor outcome. CONCLUSION: The most frequently observed sites of relapse are: lymph nodes, vagina, peritoneum and lung. Significant predictors of poor outcome in recurrent disease are multiple sites of disease and liver and splenic metastases.


Subject(s)
Adenocarcinoma/diagnostic imaging , Endometrial Neoplasms/diagnostic imaging , Neoplasm Recurrence, Local/diagnostic imaging , Neoplasms, Multiple Primary/diagnostic imaging , Tomography, X-Ray Computed , Adenocarcinoma/surgery , Adult , Aged , Aged, 80 and over , Endometrial Neoplasms/surgery , Female , Humans , Hysterectomy , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/secondary , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/secondary , Lymphatic Metastasis , Middle Aged , Multivariate Analysis , Neoplasm Recurrence, Local/surgery , Neoplasm Staging , Neoplasms, Multiple Primary/surgery , Peritoneal Neoplasms/diagnostic imaging , Peritoneal Neoplasms/secondary , Prognosis , Retrospective Studies , Splenic Neoplasms/diagnostic imaging , Splenic Neoplasms/secondary , Vaginal Neoplasms/diagnostic imaging , Vaginal Neoplasms/secondary
14.
Eur J Endocrinol ; 155(6): 813-21, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17132750

ABSTRACT

OBJECTIVE: The role of preoperative localisation of abnormal parathyroid glands remains controversial but is particularly relevant to the management of patients with recurrent or persistent hyperparathyroidism and familial syndromes. We report our experience of the use of selective parathyroid venous sampling (PVS) in the localisation of parathyroid disease in such patients. DESIGN: We report a retrospective 10-year experience (n = 27) of the use of PVS in complicated primary hyperparathyroidism and contrast the use of PVS with neck ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) and sestamibi imaging modalities. RESULTS: In 14 out of 25 patients who underwent surgery PVS results were completely concordant with surgical and histological findings and 88% of patients achieved post-operative cure. Out of 13 patients referred after previous failed surgery, 12 underwent further surgery which was curative in 9. In total PVS yielded useful positive (n = 13) and/or negative information (n = 6) in 19 out of 25 patients undergoing surgery. Using histology as the gold standard, 59% of PVS studies were entirely consistent with histology, as compared with 39% of ultrasound scans, 36% of sestamibi scans and 17% of MRI/CT scans. CONCLUSIONS: PVS is a valuable adjunct to MRI/CT and sestamibi scanning in selected patients with complicated hyperparathyroidism when performed in an experienced unit.


Subject(s)
Hyperparathyroidism/pathology , Parathyroid Glands/blood supply , Parathyroid Glands/pathology , Vena Cava, Superior , Adult , Aged , Female , Humans , Hyperparathyroidism/diagnostic imaging , Hyperparathyroidism/surgery , Magnetic Resonance Imaging , Male , Middle Aged , Parathyroid Glands/diagnostic imaging , Parathyroid Hormone/blood , Parathyroid Neoplasms/diagnostic imaging , Parathyroid Neoplasms/pathology , Parathyroid Neoplasms/surgery , Preoperative Care , Radionuclide Imaging , Radiopharmaceuticals , Reoperation , Retrospective Studies , Technetium Tc 99m Sestamibi , Tomography, X-Ray Computed
15.
Gynecol Oncol ; 101(2): 244-9, 2006 May.
Article in English | MEDLINE | ID: mdl-16310245

ABSTRACT

OBJECTIVES: Although invasion of the bladder or rectum is rare in cervical carcinoma, endoscopic assessment of both organs is part of the standard FIGO clinical staging system, with associated increase in cost and risk of complications. Our objective was to evaluate whether MRI could be used to select patients who did not require invasive staging of the bladder or rectum. METHODS: Two observers, blinded to the results of cystoscopy and endoscopic examination of the rectum, retrospectively reviewed the MR images of 112 patients with cervical carcinoma. A 5-point invasion score was used to determine bladder and rectal invasion (1 = no invasion, 5 = definite invasion). A confidence score of 3 or above was used to identify patients with possible bladder or rectal involvement. The results of cystoscopy and endoscopic examination of the rectum were recorded and correlated with the MR findings. RESULTS: MRI was negative for both bladder and rectal invasion in 94/112 patients. Cystoscopy and endoscopic examination of the rectum were confirmed to be normal in all 94 cases. MRI identified 12 patients with possible rectal invasion, 2 confirmed at endoscopy. MRI identified 14 patients with possible bladder invasion, one confirmed at cystoscopy. Using a low threshold cut-off score of >3 to predict invasion resulted in a 100% negative predictive value (NPV) in detection of bladder and rectal invasion. CONCLUSION: The absence of bladder or rectal invasion can be diagnosed with sufficient confidence using an MRI scoring system to safely obviate the need for invasive cystoscopic or endoscopic staging in the majority of patients with cervical cancer. This could potentially lead to a reduction in staging costs and morbidity.


Subject(s)
Magnetic Resonance Imaging/methods , Rectal Neoplasms/secondary , Urinary Bladder Neoplasms/secondary , Uterine Cervical Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Middle Aged , Neoplasm Invasiveness , Neoplasm Staging , Rectal Neoplasms/diagnosis , Retrospective Studies , Urinary Bladder Neoplasms/diagnosis , Uterine Cervical Neoplasms/diagnosis
17.
Clin Radiol ; 60(9): 953-9, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16124976

ABSTRACT

An understanding of the embryology of the adrenal glands is necessary to appreciate the location of adrenal ectopic, or rest, tissue which can occur anywhere along the course of gonadal descent. This tissue usually has no clinical significance, but may become hyperplastic in patients with primary or secondary adrenal pathology. In congenital adrenal hyperplasia, hyperplastic rest tissue may present as a soft-tissue mass, particularly in the gonads and retroperitoneum, and may be mistaken for tumour. The adrenal in the neonate is proportionately much larger than in the adult; in renal ectopy or agenesis the ipsilateral adrenal is normally sited and may be mistaken for a kidney because of its size. This review article illustrates the embryology of the adrenal with particular emphasis on the relevance of embryology to pathology.


Subject(s)
Adrenal Glands/diagnostic imaging , Adrenal Glands/embryology , Adrenal Hyperplasia, Congenital/diagnostic imaging , Adrenal Gland Neoplasms/diagnostic imaging , Adrenal Rest Tumor/diagnostic imaging , Female , Humans , Infant, Newborn , Kidney/abnormalities , Kidney/diagnostic imaging , Male , Testicular Neoplasms/diagnostic imaging , Testis/diagnostic imaging , Tomography, X-Ray Computed
18.
Best Pract Res Clin Endocrinol Metab ; 19(2): 293-310, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15763702

ABSTRACT

Technological developments in cross-sectional imaging have revolutionized the localization and characterization of functioning adrenal pathology. With effective use of modern imaging, the diagnosis of the cause and nature of functioning adrenal pathology can be reached speedily, accurately and efficiently in the majority of patients. We review the appearance of primary and secondary adrenal pathology, evaluate the diagnostic performance of imaging modalities, highlight newer technical developments, and propose a rational use of these tests in identifying functioning adrenal disease.


Subject(s)
Adrenal Gland Diseases/diagnosis , Diagnostic Imaging/methods , Adrenal Gland Diseases/diagnostic imaging , Adrenal Gland Diseases/pathology , Humans , Magnetic Resonance Imaging/methods , Radionuclide Imaging/methods , Tomography, X-Ray Computed/methods
19.
Clin Radiol ; 60(3): 340-8, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15710137

ABSTRACT

AIMS: To evaluate the accuracy of ultrasonography (US) and magnetic resonance imaging (MRI) in characterizing adnexal masses, and to determine which patients may benefit from MRI. METHODS: We prospectively studied 72 women (mean age 53 years, range 19 to 86 years) with clinically suspected adnexal masses. A single experienced sonographer performed transabdominal and transvaginal greyscale spectral and colour Doppler examinations. MRI was carried out on a 1.5T system using T1, T2 and fat-suppressed T1-weighted sequences before and after intravenous injection of gadolinium. The adnexal masses were categorized as benign or malignant without knowledge of clinical details, according to the imaging features which were compared with the surgical and pathological findings. RESULTS: For characterizing lesions as malignant, the sensitivity, specificity and accuracy of MRI were 96.6%, 83.7% and 88.9%, respectively, and of US were 100%, 39.5% and 63.9%, respectively. MRI was more specific (p<0.05) than US. Both MRI and US correctly diagnosed 17 (24%) cases with benign and 28 (39%) cases with malignant masses. MRI correctly diagnosed 19 (26%) cases with benign lesion(s), which on US were thought to be malignant. The age, menopausal status and CA-125 levels in these women made benign disease likely, but US features were suggestive of malignancy (large masses and solid-cystic lesions with nodules). CONCLUSION: MRI is more specific and accurate than US and Doppler assessment for characterizing adnexal masses. Women who clinically have a relatively low risk of malignancy but who have complex sonographic features may benefit from MRI.


Subject(s)
Adnexal Diseases/diagnosis , Magnetic Resonance Imaging , Ultrasonography, Doppler, Color , Adnexal Diseases/diagnostic imaging , Adult , Aged , Aged, 80 and over , Diagnosis, Differential , Female , Humans , Middle Aged , Patient Selection , Prospective Studies , Sensitivity and Specificity
20.
Clin Endocrinol (Oxf) ; 61(5): 553-9, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15521956

ABSTRACT

BACKGROUND: Primary nodular adrenocortical hyperplasia (PNAH) is a well recognized, but infrequently studied cause of paediatric Cushing's syndrome (CS). OBJECTIVE: To assess presentation, diagnosis, radiological imaging, treatment and molecular analysis of patients with childhood-onset CS due to PNAH. PATIENTS: Four males and two females (median age 12.9 years, range 10.9-16.9 years) were studied. RESULTS: All had growth failure (mean height SDS -1.2; range -2.5-0.0), weight gain [mean body mass index (BMI) SDS 3.5; range 2.5-4.6] and clinical virilization, while five had hypertension [mean systolic blood pressure (SBP) 130 mmHg, diastolic blood pressure (DBP) 83 mmHg]. One patient had generalized lentigines, one had a tibial chondromyxomatous cyst and two had facial freckling. One patient had a family history of primary nodular adrenocortical disease. The diagnosis of CS was based on elevation of sleeping midnight serum cortisol and urinary free cortisol excretion, and impaired suppression of cortisol on both low- and high-dose dexamethasone suppression tests (DST). All patients had undetectable plasma ACTH with absent responses of both plasma ACTH and serum cortisol to an intravenous (i.v.) corticotrophin-releasing hormone (CRH) test. Computed tomography or magnetic resonance imaging showed normal or small adrenals, with nodules in two patients. All patients underwent bilateral adrenalectomy, performed by open (n = 2) or laparoscopic surgery (n = 4) at a mean of 0.4 years (range 0.2-0.8 years) from diagnosis. Hypercortisolaemia was treated preoperatively by metyrapone alone 0.50-0.75 g/day (n = 4), metyrapone 0.75-1.50 g/day + o'p'DDD/mitotane 1-2 g/day (n = 1), or ketoconazole (n = 1). Adrenal histology showed nodular cortical hyperplasia with shrinkage of intervening cortical tissue and pigmentation, present in four patients. Molecular analysis of the type 1-alpha regulatory subunit of protein kinase A (PRKAR1A) gene revealed a novel germline mutation in one patient. Postadrenalectomy, three patients, had catch-up growth with height velocities increasing from 3.0, 3.9 and 2.5-8.9, 8.3 and 9.0 cm/years, respectively. All six are well at a follow-up (mean 4.0 years; range 0.5-10.8 years). CONCLUSIONS: PNAH was associated with cushingoid features, virilization and hypertension with a lack of cortisol suppression on high DST, undetectable plasma ACTH and absent cortisol and ACTH responses to CRH. Adrenals were normal or small on imaging. PRKAR1A gene analysis may be helpful in the assessment of these patients.


Subject(s)
Adrenal Hyperplasia, Congenital/complications , Cushing Syndrome/etiology , Adolescent , Adrenal Hyperplasia, Congenital/genetics , Adrenal Hyperplasia, Congenital/surgery , Adrenalectomy , Child , Cushing Syndrome/genetics , Cushing Syndrome/surgery , Cyclic AMP-Dependent Protein Kinase RIalpha Subunit , Cyclic AMP-Dependent Protein Kinases/genetics , Female , Fludrocortisone/therapeutic use , Follow-Up Studies , Humans , Hydrocortisone/blood , Hydrocortisone/therapeutic use , Male , Point Mutation , Sequence Analysis, DNA
SELECTION OF CITATIONS
SEARCH DETAIL
...