ABSTRACT
Sex differences in stress-related diseases such as stroke and stomach cancer are well established, but the mechanisms underlying this phenomenon remain unknown. Despite the fact that sexual hormones play an important role in the high resistance of females to harmful effects of stress compared with males, the regulation of oxygenation status can be a potential factor, which might explain sex differences in stress-induced cerebrovascular catastrophes in newborn rats and in mutagens activation in adult rats with stomach cancer.
Subject(s)
Cerebral Cortex/metabolism , Gastric Mucosa/metabolism , Oxygen/metabolism , Stomach Neoplasms/etiology , Stress, Psychological/complications , Stroke/etiology , Animals , Animals, Newborn , Cell Hypoxia , Cerebral Cortex/pathology , Disease Models, Animal , Female , Gastric Mucosa/pathology , Housing, Animal , Male , Nitrosamines , Noise/adverse effects , Oxygen/blood , Rats , Sex Factors , Stomach Neoplasms/genetics , Stomach Neoplasms/metabolism , Stomach Neoplasms/pathology , Stress, Psychological/metabolism , Stroke/metabolism , Stroke/pathology , Tumor HypoxiaABSTRACT
We studied the level of blood oxygen saturation (SpO2) in the brain in newborn rats in the pre- and post-stroke periods, as well as the changes in cerebral blood flow and beta-arrestin-1 as a marker of hypoxic stress. Our results show that mild hypoxia precedes the stroke development and is associated with venous relaxation and decrease blood outflow from the brain resulting in the elevation of synthesis of beta-arrestin-1 in the brain. The incidence of stroke is characterized by severe hypoxia, which is accompanied by the progression of pathological changes in cerebral veins and the high level of beta-arrestin-1.
