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J Endocrinol ; 217(1): 83-94, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23386058

ABSTRACT

Knowledge of uterine cervical epithelial biology and factors that influence its events may be critical in understanding the process of cervical remodeling (CR). Here, we examine the impact of exogenous vascular endothelial growth factor (VEGF) on uterine cervical epithelial growth in mice (nonpregnant and pregnant) treated with VEGF agents (recombinant and inhibitor) using a variety of morphological and molecular techniques. Exogenous VEGF altered various uterine cervical epithelial cellular events, including marked induction of growth, edema, increase in inter-epithelial paracellular space, and recruitment of immune cells to the outer surface of epithelial cells (cervical lumen). We conclude that VEGF induces multiple alterations in the uterine cervical epithelial tissues that may play a role in local immune surveillance and uterine cervical growth during CR.


Subject(s)
Cervix Uteri/drug effects , Cervix Uteri/immunology , Epithelial Cells/drug effects , Epithelial Cells/immunology , Immunologic Surveillance/drug effects , Peptide Fragments/adverse effects , Vascular Endothelial Growth Factor A/agonists , Angiogenesis Inhibitors/administration & dosage , Angiogenesis Inhibitors/therapeutic use , Animals , Cell Proliferation/drug effects , Cervix Uteri/blood supply , Cervix Uteri/ultrastructure , Edema/chemically induced , Edema/immunology , Edema/pathology , Edema/prevention & control , Endothelium, Vascular/drug effects , Endothelium, Vascular/immunology , Endothelium, Vascular/ultrastructure , Epithelial Cells/ultrastructure , Female , Gene Expression Regulation/drug effects , Mice , Mice, 129 Strain , Mice, Inbred C57BL , Neovascularization, Pathologic/chemically induced , Neovascularization, Pathologic/immunology , Neovascularization, Pathologic/pathology , Neovascularization, Pathologic/prevention & control , Peptide Fragments/administration & dosage , Peptide Fragments/antagonists & inhibitors , Peptide Fragments/genetics , Pregnancy , Pregnancy Complications/chemically induced , Pregnancy Complications/immunology , Pregnancy Complications/pathology , Pregnancy Complications/prevention & control , Recombinant Proteins/administration & dosage , Recombinant Proteins/adverse effects , Recombinant Proteins/antagonists & inhibitors , Uterine Cervical Diseases/chemically induced , Uterine Cervical Diseases/immunology , Uterine Cervical Diseases/pathology , Uterine Cervical Diseases/prevention & control , Vascular Endothelial Growth Factor A/administration & dosage , Vascular Endothelial Growth Factor A/adverse effects , Vascular Endothelial Growth Factor A/antagonists & inhibitors
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