ABSTRACT
Peculiarities of repair of DNA injuries induced by radiation and hyperthermia and their realization on chromosomal level in bone marrow cells ofexperimental animals with different radiation sensitivity were studied. It is shown that radiomodification efficiency of mild hyperthermia is higher for radioresistant animals. More intensive elimination of chromosomal injuries the level of which in remote terms of examination corresponds to the control value, is observed. In the group of animals with higher radiation sensitivity prolonged thermal potentiation of radiation effects on chromosomal level is determined.
Subject(s)
Bone Marrow/radiation effects , Chromosome Aberrations , Chromosomes, Mammalian/radiation effects , Metaphase/radiation effects , Radiation Tolerance , Animals , Bone Marrow/pathology , Comet Assay , DNA Damage , DNA Repair , Dose-Response Relationship, Radiation , Fever , Mice , Mice, Inbred C3H , Mice, Inbred CBA , Whole-Body Irradiation , X-RaysABSTRACT
The results of experimental investigations of the role of DNA repair as the key factor of human individual radiosensitivity formation are presented. It is shown that repair potential of hypersensitive to irradiation individuals is approximately twice lower as compared with the control group.
Subject(s)
Chromosome Aberrations/radiation effects , DNA Repair/radiation effects , Gamma Rays/adverse effects , Lymphocytes/radiation effects , Radiation Tolerance , Cells, Cultured , HumansABSTRACT
In accordance with the fundamental principles of the radiation cytogenetics the scheme of cytogenetical examinations of individual radiosensitivity of relatively healthy donors on the basis of chromosomal test (G2-assay) has been developed and tested.
