[Efficacy of cereton in acute ischemic stroke: results of the trial SOLNTSE].

We studied 95 patients with acute (no later than 24h after onset) carotid ischemic stroke. Patients of the main group (50 patients) received cereton in dose 4 ml (1000 mg) intravenously during 10 days in the combination with traditional treatment; 45 patients of the control group received only traditional treatment. Neurological deficit on NIHSS and vigilance on The Glasgow Coma Scale were assessed at baseline and in 5th, 7th and 19-21th days. The Barthel index was used to measure functional independence of the patient at the discharge from a hospital (21th day). The "cost-effectiveness" ratio, the cost of one score on the NIHSS and Barthel scales were calculated. The reduction in neurological deficit (p<0.05) and higher extent of functional independence were seen in the main group compared to the controls. Based on the "cost-effectiveness" analysis, the use of cereton was shown to be more effective for treatment of patients with acute ischemic stroke: the cost of the achievement of positive effect in patients of the control group receiving only traditional treatment was significantly higher (p<0.05).

[Mechanisms of formation of chronic low back pain relapse and their correction in patients with dorsopathy].

A clinical-neurological, psychological, biochemical and electromyographic study of 40 operated and 40 non-operated patients with chronic low back pain syndrome was conducted before and after treatment. The authors used various modes of administration of xydifonum, a chelate from the group of bisphosphonates, including electrophoretic, peroral and administration in the form of ointment, administered in turn with heparin one to improve the antiplatelet effect, using photopheresis the with the help of the state-of-the art photomatrix LED equipment. The application of Ca2+-modulating properties of xydifonum demonstrate its universality in achieving of analgesic, muscle-relaxing, anxiolytic and antidepressant effects thus allowing to exclude polypragmasy. This is a main difference between this drug and other medications with limited effects. Based on the results obtained, the authors propose a scheme of development of chronic low back pain.