Biologically potent organotin(iv) complexes of N-acetylated ß-amino acids with spectroscopic, X-ray powder diffraction and molecular docking studies.

Twelve novel organotin(iv) complexes (1-12) of N-acetylated ß-amino acids (L1-L8) were synthesized and characterized by elemental analysis, FTIR, multinuclear (1H, 13C, 119Sn) NMR, EI-MS and powder XRD techniques. The XRD results determined lattice parameters, average particle size, and intrinsic strain and confirmed the crystalline nature of complexes as face centered cubic phases. Molecular docking analysis using a catalytic pocket of the α-glucosidase enzyme indicated that most of the compounds displayed a well-fitted orientation and occupied important amino acids in the enzyme's catalytic pocket. Furthermore, in vitro α-glucosidase inhibitory activity results revealed that L1 and complexes 4, 6 and 10 showed the highest activity with IC50 values of 21.54 ± 0.45, 37.96 ± 0.81 and 35.20 ± 1.02, respectively, compared to standard acarbose with an IC50 value of 42.51 ± 0.21. In addition, in vivo antidiabetic activity of selected compounds using alloxan induced diabetic rabbits showed that L4 and complexes 4, 6, 10, 12 showed significant activities like standard metformin. Anti-bacterial activity against the selected Gram-positive and Gram-negative bacterial strains has the following order Escherichia coli > Pseudomonas aeruginosa > Staphylococcus aureus > Bacillus subtilis. Similarly, antioxidant activity by the DPPH scavenging method was also studied with following results: triorganotin > diorganotin > ligands.

Development of efficient bi-functional g-C3N4@MOF heterojunctions for water splitting.

Herein we report the development of highly efficient heterojunctions by combining n-type g-C3N4 and MOFs as bi-functional photoelectrocatalysts towards the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER). g-C3N4@MIL-125(Ti) and g-C3N4@UiO-66 have been synthesized via in situ incorporation of pre-synthesized g-C3N4 nanoparticles into MIL-125(Ti) and UiO-66. Bare MIL-125(Ti) and UiO-66 are also prepared for comparison. All the synthesized samples have been characterized by Powder X-ray Diffraction analysis, Fourier Transform Infrared Spectroscopic analysis, Scanning Electron Microscopic analysis, Energy Dispersive X-ray Spectrometry and UV-Vis Spectroscopic analysis. Cyclic voltammetry and linear sweep voltammetry studies have been carried out for all samples which indicates that under visible light exposure the g-C3N4@MIL-125(Ti)/NF heterojunction achieved a current density of 10 mA cm-2 at just 86 and 173 mV overpotential for the HER and OER, respectively. Moreover, all the synthesized samples display significant stability and generate a constant current density up to 1000 cyles during water electrolysis performed at a constant applied potential 1.5 V.