Neoplasias primarias malignas múltiples en pacientes con cáncer gástrico en el área sanitaria de León / Multiple malignant primary neoplasms in patients with gastric neoplasms in the health district of León

Objetivos: analizar las características de los pacientes con tumores gástricos diagnosticados de una neoplasia primaria maligna múltiple (NPMM) en el área sanitaria de León. Pacientes y método: utilizando los datos del Registro de Tumores del Hospital de León se han seleccionado aquellos pacientes con tumores gástricos diagnosticados entre 1993 y 2002. Se realizó un seguimiento hasta el 31 de diciembre de 2004 analizando las características de los pacientes diagnosticados de una segunda neoplasia durante el periodo de seguimiento. Resultados: la prevalencia de NPMM fue del 1,96%. El 56% de los pacientes tenían antecedentes oncológicos en familiares de primer grado. Las segundas neoplasias más frecuentes fueron las digestivas (26%) y las urológicas (21%). El 87% de los pacientes fueron diagnosticados del segundo tumor en los primeros dos años. No se observaron diferencias respecto a la supervivencia entre los pacientes con NPMM sincrónicas y metacrónicas. Conclusiones: las NPMM en los pacientes con cáncer gástrico son un problema relevante. Aunque los agentes carcinógenos externos puedan actuar como promotores en el desarrollo de una segunda neoplasia, en estos pacientes parece existir una base genética que favorece el desarrollo del una NPMM. La prevención secundaria es la mejor medida para evitar el desarrollo de una NPMM

Objectives: we analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León. Material and methods: using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed. Results: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN. Conclusions: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development

[Analysis of the characteristics of patients with bladder cancer diagnosed of multiple neoplasms in the health district of León (Spain)]. / Análisis de las características de los pacientes con cáncer vesical diagnosticados de neoplasias múltiples en el área sanitaria de León.

OBJECTIVE: We analyzed the characteristics of the patients with bladder neoplasms who developed a multiple malignant primary neoplasm (MMPN) in the health district of León, the impact on survival and the prognostic variables. MATERIAL AND METHODS: We have used the data from the Tumor Registry of the Hospital of León and selected all those patients who were diagnosed of a bladder tumor between 1993 and 2002. They were classified into two groups: the first with 71 patients with MMPN and a second group with 159 patients with single bladder tumors diagnosed between 1996 and 1997. RESULTS: Incidence of MMPN was of 7.1 percent. More than half of the patients had familial oncologic background. The second most frequently diagnosed neoplasms were urologic, followed by gastrointestinal and respiratory. Survival of patients with MMPN was 21 percent lower than single neoplasms. Variables with prognosis significance were the stage of the second neoplasm, diagnosis of a second urologic neoplasm and surgery treatment for the second tumor. CONCLUSIONS: MMPN in patients with bladder tumors are frequent in our geographic area. The high frequency of familial oncologic antecedents in these patients suggest a genetic background. Prognosis of MMPN patients is worse than single tumors patients, but no differences were observed regarding prognosis in patients with synchronous or metachronous MMPN.

Cáncer colo-rectal multicéntrico (CCRM) en el área sanitaria de León / Multicentric colo-rectal cancer (MSCC) in the health district of León

Objetivos: Analizar las características de los pacientes diagnosticados de CCRM en el área sanitariade León, el impacto sobre la supervivencia y las posibles variables pronósticas.Material y métodos: Utilizando los datos del Registro de Tumores del Hospital de León se hananalizado las características de aquellos pacientes con tumores colo-rectales diagnosticados entre 1993y 2002, clasificándolos dos grupos: el primero constituido por 74 pacientes diagnosticados de CCRMy el segundo formado por 1342 pacientes con tumores únicos diagnosticados en el bienio 1996-1997.Resultados: La frecuencia de CCRM fue del 2,7%. La edad de los pacientes con CCRM fue 2años mayor con respecto a la de los pacientes con neoplasias únicas, con una elevada proporción(38%) de antecedentes familiares oncológicos en familiares de primer grado. No se observaron diferenciassignificativas en cuanto a la localización y el estadio del primer tumor colo-rectal con respectoal grupo de tumores únicos. La supervivencia de los pacientes con CCRM metacrónico fue netamenteinferior, posiblemente en relación con un mayor número de segundas neoplasias diagnosticadas en estadiostempranos en los pacientes con CCRM sincrónico. Las variables que influyeron en el pronósticofueron la edad, el sexo, y el padecimiento de un CCRM sincrónico o metacrónico.Conclusiones: El CCRM es una entidad frecuente en nuestro medio. La tasa de antecedentes familiaresoncológicos en estos pacientes es muy elevada. No se encontraron diferencias significativasen cuanto al pronóstico de estos pacientes respecto al de los pacientes con neoplasias únicas

Purpose: We analyze the characteristics of patients with multicentric colo-rectal cancer (MCRC)in the health district of León, the impact on survival, and the prognostic variables.Material and methods: : Using the data from the Hospital de León Tumour Registry, weanalyzed the characteristics of all the patients diagnosed of having colo-rectal tumours between 1993and 2002. The patients were classified in two groups: one of them composed by 74 patients with MCRC,and the other formed by 1342 patients diagnosed in 1996 and 1997 of having single colo-rectal tumours.Results: The observed frequency of MCRC corresponded to 2.7 percent of the whole cases. Theage of the MCRC patients was 2 years higher than that of the patients with single neoplasms, andshowed a higher familial oncologic history, that was present in 38 percent of the cases. No differenceswere observed for location and stage of the first appeared colo-rectal neoplasm. The survival of thepatients developing metachronous MCRC was lower than for those with synchronous disease,possibly due to the higher number of the second neoplasms appearing in these patients at early stages.Prognostic values were age, sex, and metachronous or synchronous type of disease.Conclusions: MCRC is a frequent entity. The frequency of familial oncologic history is veryhigh. No significant differences were seen in relation to prognosis between single and multiple colorectalcancer

Multiple malignant primary neoplasms in patients with gatric neoplasms in the health district of León.

OBJECTIVES: We analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León. MATERIAL AND METHODS: Using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed. RESULTS: MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN. CONCLUSIONS: MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development.

[Incidence of digestive tumors in the health district of Leon, Spain in 1993-1997: high incidence of colorectal carcinoma]. / Incidencia de los tumores digestivos en el Area de Salud de León en el quinquenio 1993-1997: alta incidencia del carcinoma colorrectal.

AIM: To determine the incidence of various digestive tumors in the health district of Leon. PATIENTS AND METHODS: All digestive tumors registered in the Hospital Tumor Registry in Leon from 1993-1997 were included. Unadjusted and adjusted incidence rates of each kind of tumor, using the ICD-9 classification, were calculated. RESULTS: A total of 9,913 cancer cases were included. Diagnosis was confirmed by the Department of Pathology in 93.4%. Of these, 25.38% originated primarily in the digestive system, which represents an unadjusted incidence of 151.73 new cases per 100,000 inhabitants/year. A total of 58.07% were male and 41.93% female. Colon cancer was the most frequent (31.5%), followed by gastric cancer (25.7%) and rectal cancer (20.3%). The highest incidence, both unadjusted and adjusted, was in colon cancer (52.8 and 25.9) followed by gastric cancer (47.4 and 24.3) and rectal cancer (36.1 and 18.3, all they 10(5)/year. CONCLUSIONS: Incidence of digestive cancer in Leon is very high and that of colorectal cancer is higher than in any other region in Spain. This is only partly due to the marked aging of our population.

[A histopathological study of the hepatic changes induced by parenteral nutrition in the rat]. / Estudio histopatológico de las alteraciones hepáticas inducidas por la nutrición parenteral en la rata.

Total parenteral nutrition is associated with hepatic metabolic and morphologic changes. Histological alterations induced by administration of glucose plus amino acids (group A) or glucose plus amino acids and lipids (group B) have been investigated in the rat. Parenteral nutrition provided 187 kcal/kg/day in both groups of animals. Rats in group B received 30% of nonprotein calories as lipids (Intralipid). In group A the most frequent histopathological findings were inflammation, portal edema and microesteatosis. Those alterations did not disappear by lipid addition, being frequent the existence of congestive phenomenons and esteatosis together with occasional pigment deposits in Kupffer cells. Those data suggest that supplementation of solutions with LCT-base lipid emulsions does not compensate for the histopathological alterations induced by parenteral nutrition.