Quality of measurement properties of medication adherence instruments in cardiovascular diseases and type 2 diabetes mellitus: a systematic review and meta-analysis.

BACKGROUND: Medication adherence has a major impact on reducing mortality and healthcare costs related to the treatment of cardiovascular diseases and diabetes mellitus. Selecting the best patient-reported outcome measure (PROM) among the many available for this kind of patient is extremely important. This study aims to critically assess, compare and synthesize the quality of the measurement properties of patient-reported outcome measures to assess medication adherence among patients with cardiovascular diseases and/or type 2 diabetes mellitus. METHODS: This review followed the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidelines and was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). The searches were performed in Web of Science, SCOPUS, PubMed, CINAHL, EMBASE, LILACS, PsycINFO, and ProQuest (gray literature). RESULTS: A total of 110 records encompassing 27 different PROMs were included in the review. The included records were published between 1986 and 2023, most of which reported studies conducted in the United States and were published in English. None of the PROMs were classified in the category "a", thus being recommended for use due to the quality of its measurement properties. The PROMs that should not be recommended for use (category "c") are the MTA, GMAS, DMAS-7, MALMAS, ARMS-D, and 5-item questionnaire. The remaining PROMs, e.g., MMAS-8, SMAQ, MEDS, MNPS, ARMS-12, MGT, MTA-OA, MTA-Insulin, LMAS-14, MARS-5, A-14, ARMS-10, IADMAS, MAQ, MMAS-5, ProMAS, ARMS-7, 3-item questionnaire, AS, 12-item questionnaire, and Mascard were considered as having the potential to be recommended for use (category "b"). CONCLUSION: None of the included PROMs met the criteria for being classified as trusted and recommended for use for patients with cardiovascular diseases and/or type 2 diabetes mellitus. However, 21 PROMs have the potential to be recommended for use, but further studies are needed to ensure their quality based on the COSMIN guideline for systematic reviews of PROMs. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019129109.

Methods to assess ambivalence towards food and diet: a scoping review.

BACKGROUND: Ambivalence towards food and diet, which favours behavioural inertia, might be a barrier to adopting healthier eating behaviours. Measuring it can help researchers to better understand its relationship with behaviour change and design interventions aimed at resolving it. In this scoping review, we map and describe methods and tools employed in studies to assess, measure or classify the ambivalence of participants towards food- and diet-related attitude objects. METHODS: In accordance with Joanna Briggs Institute guidance for conducting scoping reviews, we retrieved peer-reviewed studies from MEDLINE, CINAHL, PsycINFO, Web of Science, FSTA and Food Science Source and preprints from PsyArXiv and MedRxiv. Two independent reviewers screened the articles. We considered for inclusion peer-reviewed studies and preprints that assessed the ambivalence of participants of any age, sex or sociodemographic group towards food and diet. RESULTS: We included 45 studies published between 1992 and 2022, which included participants from 17 countries. Eighteen methods were employed across the included studies to assess different types of ambivalence (felt, potential or cognitive-affective), the most frequent of which were the Griffin Index, the Subjective Ambivalence Questionnaire, the MouseTracker Paradigm and the Orientation to Chocolate Questionnaire. CONCLUSION: This scoping review identified several methods and tools to assess different types of ambivalence towards food- and diet-related objects, providing an array of options for future studies.

Focused review on nutritional status of patients with immunoglobulin light chain amyloidosis.

BACKGROUND: Immunoglobulin light chain (AL) amyloidosis is a complex disease marked by a poor clinical portrait and prognosis generally leading to organ dysfunction and shortened survival. We aimed to review the available evidence on whether AL amyloidosis can lead to malnutrition, thus having a negative impact on quality of life (QoL) and survival. MATERIALS: We searched Pubmed for studies that assessed malnutrition in amyloidosis patients, with no restrictions to the year of publication or language. Retrospective or prospective, observational, and interventional studies that reported data regarding AL amyloidosis and nutritional status were included. RESULTS: From 62 articles retrieved, 23 were included. Malnutrition was prevalent in up to 65% of patients with AL Amyloidosis. Prevalence of weight loss of 10% or more ranged from 6 to 22% of patients, while a body mass index of < 22 kg/m2 was found in 22 to 42%. Weight loss, lower BMI and other indicators of poor nutritional status were negatively associated with quality of life and survival. Only one RCT focused on nutritional counseling was found and reported positive results on patients QoL and survival. CONCLUSION: Despite inconsistencies across assessment criteria, the available data reveal that weight loss and malnutrition are common features in patients with AL amyloidosis. This review reinforces the premise that an impaired nutritional status can be negatively associated with QoL and survival in patients with AL amyloidosis, and therefore should be further investigated.

The improvement of cardiorespiratory fitness in healthy women after a 12-week Classical Pilates training / A melhoria da aptidão cardiorrespiratória em mulheres saudáveis depois de 12 semanas de treinamento no Pilates Clássico

Aims: to evaluate the effects of 12 weeks of Pilates training (Classical Method) on cardiorespiratory fitness and heart rate responses of healthy sedentary women. Method: fifteen women (average age 29±4) performed 12 weeks of Pilates training for 60 minutes, three times per week (Pilates Group). Thirteen women (average age 29±5) as controls maintained their routine activities (Control Group). The exercises' introduction was by the degree of difficulty with changes in the plane of movements; smaller base of support; spinal rotations and extensions; use of abdominal muscles in prone position. Heart rate was monitored and recorded during all sessions using a heart frequency meter. Results: ANOVA analysis results revealed significant difference in Pilates Group (p < 0.05) between pre and post measures of VO2peak (+13%), fat percentage (- 3.3%), free fat mass (+ 2.8 kg), and muscular endurance in the abdominal area (+61%), lower limbs (+75%) and upper limbs (+68%). The percent of Maximum Heart Rate achieved in the 6th (79.25%) and 12th (79.86%) weeks of training increased from the first week (73.4%). Physical fitness in Control Group remained unchanged. Conclusion: twelve weeks of Pilates training positively affected overall physical fitness in previously sedentary healthy women. Furthermore, the increase in VO2peak and achieved Maximum Heart Rate was significant even with no specific aerobic training.

Objetivos: avaliar os efeitos de 12 semanas de treinamento de Pilates (Método Clássico) sobre o condicionamento cardiorrespiratório e respostas da frequência cardíaca de mulheres sedentárias saudáveis. Métodos: quinze mulheres realizaram 12 semanas de treinamento de Pilates durante 60 minutos, três vezes por semana (Grupo Pilates), com média de idade 29±4 anos. Treze mulheres com idade compatível com os controles mantiveram suas atividades rotineiras (Grupo Controle), com média de idade de 29±5 anos. A introdução dos exercícios foi pelo grau de dificuldade com mudança nos planos de movimento; menor base de suporte; rotação e extensão da coluna; e ativação da musculatura abdominal em posição de decúbito ventral. A frequência cardíaca foi monitorada e gravada durante todas as sessões usando um frequencímetro. Resultados: Os resultados da ANOVA revelaram diferença significativa no Grupo Pilates (p < 0,05) entre medidas pré e pós de VO2pico (+13%), percentual de gordura (- 3,3%), massa gorda livre (+ 2,8 kg), e resistência muscular da área abdominal (+61%), membros inferiores (+75%) e dos membros superiores (+68%). O percentual de Frequência Cardíaca Máxima alcançado na sexta (79,25%) e na décima primeira (79,86%) semanas de treinamento aumentou a partir da primeira semana (73,4%). A aptidão física do Grupo Controle permaneceu inalterada. Conclusão: doze semanas de treinamento de Pilates afetaram positivamente o condicionamento físico geral em mulheres saudáveis anteriormente sedentárias. Além disso, o aumento do VO2pico e da Frequência Cardíaca Máxima foi significativo mesmo sem treinamento aeróbico específico.

Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients.

We compared cognitive profiles in chronic heart failure patients (HF), heart transplant recipients (HT) and healthy controls (HC) and examined the relationship between cardiorespiratory fitness (V˙O2peak), peak cardiac output (COpeak) and cognitive performance. Stable HT patients (n = 11), HF patients (n = 11) and HC (n = 13) (61.5 ± 8.5 years) were recruited. Four cognitive composite scores targeting different cognitive functions were computed from neuropsychological tests: working memory, processing speed, executive functions and verbal memory. Processing speed and executive function scores were higher, which indicates lower performances in HF and HT compared to HC (p < 0.05). V˙O2peak and first ventilatory threshold (VT1) were lower in HF and HT vs. HC (p < 0.01). COpeak was lower in HF vs. HT and HC (p < 0.01). Processing speed, executive function and verbal memory performances were correlated with V˙O2peak, VT1 and peak cardiac hemodynamics (p < 0.05). Mediation analyses showed that V˙O2peak and VT1 mediated the relationship between group and processing speed and executive function performances in HF and HT. COpeak fully mediated executive function and processing speed performances in HF only. V˙O2peak and COpeak were related to cognitive performance in the entire sample. In addition, V˙O2peak and VT1 fully mediated the relationship between group and executive function and processing speed performances.

Beta-Blocker Type Effect on Substrate Oxidation during HIIE in Heart Failure Patients: Pilot Data.

The effect of third and second-generation type of beta-blocker on substrate oxidation especially during high-intensity exercises are scarce. The objective of the study is to explore differences of beta-blocker regimens (vasodilating vs. non-vasodilating beta-blockers) for substrate oxidation during in high-intensity intermittent exercise (HIIE) in chronic heart failure and reduced ejection fraction (HFrEF). Eighteen CHF males (58.8 ± 9 years), 8 under use of ß1 specific beta-blockers+alfa 1-blocker and 10 using ß1 non-specific beta-blockers, were randomly assigned to 4 different HIIE, in a cross-over design. The 4 protocols were: 30 seconds (A and B) or 90 seconds (C and D) at 100% peak power output, with passive (A and C) or active recovery (50% of PPO; B and D). Energy expenditure (EE; kcal/min), quantitative carbohydrate (CHO) and lipid oxidation (g/min) and qualitative (%) contribution were calculated. Two-way ANOVA and Bonferroni post-hoc test were used (p-value ≤ 0.05) to compare CHO and lipid oxidation at rest and at 10min. Total exercise time or EE did not show differences for beta-blocker use. The type of beta-blocker use showed impact in CHO (%) and lipid (g/min and %) for rest and 10 min, but absolute contribution of CHO (g/min) was different just at 10min (Interaction p = 0.029). Higher CHO oxidation was found in vasodilating beta-blockers when comparing to non-vasodilating. According to our pilot data, there is an effect of beta-blocker type on substrate oxidation during HIIE, but no influence on EE or exercise total time in HFrEF patients.

Beta-Blocker Type Effect on Substrate Oxidation during HIIE in Heart Failure Patients: Pilot Data / Efeito do Tipo Betabloqueador na Oxidação de Substratos durante HIIE em Pacientes com Insuficiência Cardíaca: Dados Piloto

Abstract The effect of third and second-generation type of beta-blocker on substrate oxidation especially during high-intensity exercises are scarce. The objective of the study is to explore differences of beta-blocker regimens (vasodilating vs. non-vasodilating beta-blockers) for substrate oxidation during in high-intensity intermittent exercise (HIIE) in chronic heart failure and reduced ejection fraction (HFrEF). Eighteen CHF males (58.8 ± 9 years), 8 under use of β1 specific beta-blockers+alfa 1-blocker and 10 using β1 non-specific beta-blockers, were randomly assigned to 4 different HIIE, in a cross-over design. The 4 protocols were: 30 seconds (A and B) or 90 seconds (C and D) at 100% peak power output, with passive (A and C) or active recovery (50% of PPO; B and D). Energy expenditure (EE; kcal/min), quantitative carbohydrate (CHO) and lipid oxidation (g/min) and qualitative (%) contribution were calculated. Two-way ANOVA and Bonferroni post-hoc test were used (p-value ≤ 0.05) to compare CHO and lipid oxidation at rest and at 10min. Total exercise time or EE did not show differences for beta-blocker use. The type of beta-blocker use showed impact in CHO (%) and lipid (g/min and %) for rest and 10 min, but absolute contribution of CHO (g/min) was different just at 10min (Interaction p = 0.029). Higher CHO oxidation was found in vasodilating beta-blockers when comparing to non-vasodilating. According to our pilot data, there is an effect of beta-blocker type on substrate oxidation during HIIE, but no influence on EE or exercise total time in HFrEF patients.

Resumo Os dados sobre efeito do tipo de betabloqueador de terceira e segunda geração na oxidação do substrato, especialmente durante exercícios de alta intensidade, são escassos. O objetivo do estudo é explorar as diferenças de tratamentos com betabloqueadores (betabloqueadores vasodilatadores vs. não-vasodilatadores) na oxidação de substratos durante exercícios intermitentes de alta intensidade (HIIE) na insuficiência cardíaca crônica e fração de ejeção do ventrículo esquerdo reduzida (ICFEr). Dezoito pacientes do sexo masculino com ICC (58,8 ± 9 anos), 8 em uso de betabloqueadores β1 específicos + bloqueador α-1 e 10 utilizando betabloqueadores β1 não-específicos, foram aleatoriamente designados para 4 diferentes HIIE, em um desenho cruzado. Os 4 protocolos foram: 30 segundos (A e B) ou 90 segundos (C e D) a 100% da potência de pico de saída (PPO), com recuperação passiva (A e C) ou ativa (50% de PPO; B e D). O gasto energético (GE; kcal/min), a ingestão de carboidratos quantitativos (CHO) e oxidação lipídica (g/min) e qualitativa (%) foram calculados. Anova de dois fatores e teste post-hoc de Bonferroni foram usados (p-valor ≤ 0,05) para comparar a oxidação de CHO e lipídios em repouso e aos 10 minutos. O tempo total de exercício ou GE não mostraram diferenças de acordo com o uso de betabloqueadores. O tipo de betabloqueador mostrou impacto em CHO (%) e lípides (g/min e %) para repouso e aos 10 min, mas a contribuição absoluta de CHO (g/min) foi diferente apenas aos 10 minutos (Interação p = 0,029). Foram encontradas maiores oxidações de CHO com betabloqueadores vasodilatadores quando comparados com os não-vasodilatadores. De acordo com nossos dados piloto, há um efeito do tipo do betabloqueador na oxidação do substrato durante o HIIE, mas nenhuma influência no GE ou no tempo total de exercício nos pacientes com ICFEr.

Comparison of Carbohydrate and Lipid Oxidation During Different High-Intensity Interval Exercise in Patients with Chronic Heart Failure.

Substrate oxidation was compared during different high-intensity intermittent exercise (HIIE) protocols in patients with heart failure and reduced ejection fraction (HFREF). Eighteen males with HFREF (58.8 ± 9 years) were randomly assigned to 4 different HIIEs: 30 seconds (A and B) or 90 seconds (C and D) at 100% peak power output, with passive (A and C) or active recovery (50% of peak power output; B and D). Each HIIE protocol was separated by 1 week. Substrate oxidation (carbohydrate [CHO] and lipid: in g/min and in %) was calculated with gas exchange analysis. A 2-way analysis of variance and Bonferroni post hoc test were used (P ≤ 0.05) to compare CHO and lipid oxidation during the 4 HIIEs. Protocols with passive recovery (A and C) resulted in significantly lower quantitative CHO oxidation (g/min) (interaction, P < 0.001) compared to modes with active recovery (B and D). Quantitative lipid oxidation (g/min) was significantly lower in protocol C compared to the 3 other HIIE protocols (interaction, P < 0.001). In patients with HFREF, shorter HIIE bouts with passive recovery oxidize less CHO and more lipids (quantitatively) compared to the other HIIE protocols. This might be taken into account the exercise training prescription and might influence muscle metabolism adaptations.

Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy.

Protein arginylation mediated by arginyltransferase (ATE1) is essential for heart formation during embryogenesis, however its cell-autonomous role in cardiomyocytes and the differentiated heart muscle has never been investigated. To address this question, we generated cardiac muscle-specific Ate1 knockout mice, in which Ate1 deletion was driven by α-myosin heavy chain promoter (αMHC-Ate1 mouse). These mice were initially viable, but developed severe cardiac contractility defects, dilated cardiomyopathy, and thrombosis over time, resulting in high rates of lethality after 6months of age. These symptoms were accompanied by severe ultrastructural defects in cardiac myofibrils, seen in the newborns and far preceding the onset of cardiomyopathy, suggesting that these defects were primary and likely underlay the development of the future heart defects. Several major sarcomeric proteins were arginylated in vivo. Moreover, Ate1 deletion in the hearts resulted in a significant reduction of active and passive myofibril forces, suggesting that arginylation is critical for both myofibril structural integrity and contractility. Thus, arginylation is essential for maintaining the heart function by regulation of the major myofibril proteins and myofibril forces, and its absence in the heart muscle leads to progressive heart failure through cardiomyocyte-specific defects.

Comparação de duas estratégias de desempenho para avaliação da velocidade crítica de caminhada / Comparison of two strategies for assessing critical walking velocity

O objetivo deste estudo foi comparar duas estratégias de desempenho em testes de caminhada, tempo fixo com intensidade autoselecionada e ritmo fixo, na determinação dos parâmetros da Velocidade Crítica de Caminhada (VCC). Fizeram parte da amostra 14 voluntárias (idade = 60,8 ± 10,3 anos), submetidas aleatoriamente a três testes de caminhadade tempo fixo (3, 6, e 9 minutos) e três testes com intensidade fixa, que variaram entre 10 e 15 segundos a cada 20 metros. Estes testes preditivos foram utilizados para o cálculo da VCC. O erro padrão da estimativa da VCC apresentou valor médio de 4,96% na estratégiade ritmo fixo e 2,98% na estratégia de tempo fixo, o que representa boa estimativa deste parâmetro. Os resultados apontaram alta correlação entre as estratégias de coleta para a VCC (r=0,73; p<0,01). A média dos coeficientes de determinação para o modelo de ritmo fixo foram R2 = 0,98 ± 0,03 e para tempo fixo R2 = 0,99 ± 0,002. Os resultados daANCOVA para os testes preditivos demonstraram não haver diferença entre as estratégias de coleta (p=0,38), na comparação dos sujeitos x estratégias (p=0,29) e nas estratégias x tempo (p=0,26). A regressão geométrica, comparando as estratégias tempo fixo x ritmo fixo(1,42 ± 0,14 e 1,38 ± 0,21 m/s) também não apontou diferenças, assim como o método de Bland & Altman. Concluiu-se que as duas estratégias foram equivalentes na avaliação do desempenho na amostra estudada.

The aim of this study was to compare two strategies of walking test performance (self-paced intensity and fixed pace) for the determination of critical walking velocity (CWV) parameters. Fourteen female volunteers (age = 60.8 ± 10.3 years) were randomly submitted to three fixed-time walking tests (3, 6 and 9 minutes) and three fixed-pace tests ranging from 10 to 15 seconds at intervals of 20 meters. These predictive tests were used to calculate CWV. The mean standard error of the CWV estimate was 4.96% for the fixed-pace strategy, and 2.98% for the fixed-time strategy, corresponding to an adequate estimation. The results showed a high correlation between strategies (r=0.73; p<0.01). The mean coefficient of determination was R2 = 0.98 ± 0.03 for the fixed-pace model and R2 = 0.99 ± 0.002 for the self-paced model. ANCOVA for the predictive tests showed no differences between strategies (p=0.29), subjects x strategies (p=0.29), or strategies x time (p=0.26). Geometric regression comparing the fixed-time x fixedpace strategies (1.42 ± 0.14 and 1.38 ± 0.21 m/s) or the Bland-Altman method revealed no differences between performance strategies. We conclude that the two strategies were equivalent for the evaluation of performance in the sample studied.

Programa de atividade física em unidades básicas de saúde: relato de experiência no município de Rio Claro-SP / Program of physical education in basic health units: experiment report in Rio Claro County SP

Há evidências de que o estilo de vida sedentário afeta 40 a 80% da população brasileira. Gênero, idade, condição de saúde, nível sócio-econômico e escolaridade estão associados aos maiores índices de inatividade física. Parte desse resultado pode ser creditada a barreiras individuais e ambientais que dificultam a prática de atividade física (AF). Devido às características, as Unidades Básicas de Saúde (UBS) são locais privilegiados para promoção da saúde mediante AF, uma vez que minimizam parte das barreiras presentes em grupos populacionais sujeitos à inatividade física. O objetivo deste estudo é compartilhar evidências acumuladas ao longo de 6 anos de existência de um programa de AF desenvolvido em UBS no município de Rio Claro-SP. Os resultados do programa se mostraram efetivos em melhorar o desempenho de alguns componentes da aptidão funcional, metabolismo de lipídios e glicose, estados de ânimo e qualidade de vida relacionada à saúde dos participantes. Tendo em vista os resultados apresentados e a presença de UBS na grande maioria dos municípios brasileiros, acreditamos que a implantação de um programa desta natureza seja uma iniciativa viável tanto do ponto de vista social quanto de promoção da saúde.

There are evidences that sedentary life style affects 40-80% of the Brazilian population. Gender, age, health condition, social-economic level and schooling are linked to the highest physical inactivity contents. Part of this result may be due to individual and environmental barriers which make the practice of physical activities (PA) difficult. Due to their characteristics, the Basic Health Units (BHU) are privileged places for health promotion through PA, once they minimize part of the existent barriers in groups of population subject to physical inactivity. The objective of this study is to share evidence accumulated along 6 years of existence of a PA program accomplished in a BHU in Rio Claro County - SP. The results of this program have shown effective in improving the performance of some components of functional aptitude, the metabolism of lipids and glucose, states of mood and life quality related to the health of the participants. Considering such results and the presence of BHU in most of te Brazilian Counties, we believe that the setting up of a program like this can be a viable initiative from both the social point of view and of health promotion.