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Int J Immunopathol Pharmacol ; 17(1): 27-32, 2004.
Article in English | MEDLINE | ID: mdl-15000863

ABSTRACT

Antithrombin-III exerts antiinflammatory effects via ligation of heparan sulfate proteoglycans. Here we show in vitro that recombinant human antithrombin-III attenuates CD11b/CD18 expression of activated neutrophils and monocytes in whole blood ex vivo. As leukocyte integrin expression is triggered by extracorporeal circulation, this observation may be of relevance for pharmacological treatment during cardiopulmonary bypass.


Subject(s)
Antithrombin III/pharmacology , CD18 Antigens/biosynthesis , Leukocytes/drug effects , Leukocytes/metabolism , Adult , CD18 Antigens/metabolism , Humans , Recombinant Proteins/pharmacology
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