Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Nat Genet ; 43(6): 561-4, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21572415

ABSTRACT

Genome-wide association studies have identified many genetic variants associated with complex traits. However, at only a minority of loci have the molecular mechanisms mediating these associations been characterized. In parallel, whereas cis regulatory patterns of gene expression have been extensively explored, the identification of trans regulatory effects in humans has attracted less attention. Here we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression. Expression levels of genes regulated by this trans-eQTL are highly correlated with concurrently measured metabolic traits, and a subset of the trans-regulated genes harbor variants directly associated with metabolic phenotypes. This trans-eQTL network provides a mechanistic understanding of the effect of the KLF14 locus on metabolic disease risk and offers a potential model for other complex traits.


Subject(s)
Adipose Tissue/metabolism , Cholesterol, HDL/genetics , Diabetes Mellitus, Type 2/genetics , Gene Expression Regulation , Genomic Imprinting , Sp Transcription Factors/genetics , Female , Genome-Wide Association Study , Humans , Kruppel-Like Transcription Factors , Phenotype , Polymorphism, Single Nucleotide , Quantitative Trait Loci
SELECTION OF CITATIONS
SEARCH DETAIL
...